ID V4Z409_TOXGV Unreviewed; 1709 AA.
AC V4Z409; A0A0F7UVI5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=BN1205_055630 {ECO:0000313|EMBL:CEL72128.1}, TGVEG_275630
GN {ECO:0000313|EMBL:ESS30168.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS30168.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS30168.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS30168.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS30168.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS30168.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL72128.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL72128.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; LN714492; CEL72128.1; -; Genomic_DNA.
DR EMBL; AAYL02000258; ESS30168.1; -; Genomic_DNA.
DR STRING; 432359.V4Z409; -.
DR PaxDb; 5811-TGME49_075620; -.
DR EnsemblProtists; ESS30168; ESS30168; TGVEG_275630.
DR VEuPathDB; ToxoDB:TGVEG_275630; -.
DR eggNOG; KOG0942; Eukaryota.
DR OMA; TLLQYQL; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transferase {ECO:0000313|EMBL:CEL72128.1};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1374..1709
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 101..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1677
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1709 AA; 185642 MW; 91951FFD0F1BEA19 CRC64;
MFSDFTHSSN RRIDLSGASR PAFVRGRLAA GVAGSSGAAC RSSLLEFQRR ERQLREQHRR
SVDAALKVQR CWRSSFVRRQ TKGDHRRAFD AAVAALLAGA EDGTGSGASE TGRRTRFEGK
SCETHTHGQP AARRALCIQR ALPRLIRQLA FFFDPDEDGQ RRRSPSRSQG GRQTRELEVP
TAGDASTLAT VGEAGNKLDC VARTLAQERS SGGMQVTFYA GGTTVFTDDV ARLALLCDWV
LNLGEGHAIH GRLCGTCNAS RRQAPFDVEM EDATRASINT CLFPLAAEEL RSTEQTPAPP
LTSQAPDSSS HAPSTRASAR DRLPHEPRFL QLLATTELRL LLQCAALRYR AVLFSNEAPA
SLLPPRFLVP QASEGSRDRS PAACDSSVTA APATVSLFGG RGSLGTREMR TEWGLKQDKM
TRLLGLENGN SRDEPPRRVA GLSAFSWVHL RPACGWRGSV LASSLRTFAR TDDNAATNGK
KEPATSGGVG AGESGGLGER PSALLGGQEN AEEGVDVASN LLAGRRSVGA SDPPFFLLPA
GPETPEKGVQ ELWHWIRSVR DILLAVASAS ASGDSLESDR VAEILPNSSD AGGLSRLLRS
WRVVGGGPLA AMLGDALADA MTTPAEVEEG AICGEGRTIS DRRERDLAAA VETWLCVCRA
ADDVSGELEF LVHLFGAPCL VPVFDATGPP PSPLSSSSPS VLTASRLPLL ADDESEKWRR
RTRFLTLVLG RMLSSVAGCD ALQSLLQMLQ LPQLSPKHRG ALPKSTVVTL PSRGALGGEP
PAAKQLEGQT ASRRLREAEQ QIRDLVTKDV SRRVRTEAEA ANGREGELVQ VRKSPLVLCL
AGNALGLLHN QIEVGDPDSR DWAKNRGDKE GGGQEDKAAQ RTLLCVLCWA ATFAHDELLR
QSVLSSEEQQ TGETQGEKEP GIDAALRRQL RLLMTPAVLR ALFDCADEDP PNRFPPLLRI
FFPPSLCACP SADTRVDTAP QGEAGESLSA REEPSEVESS EDETEDTMTA FNASAADPSA
DGGSEPAIGV DRLILNALAM NTSLSTHLLP VIRHVFDAEC GGDVDQFLRR LGPAPFFDAP
LGQVLRAACT LLQYQLELMY DSELVETSRS APLPGFRPPA SSSSSSSSSS SLAPLSSSPL
LTASDFQWLS LTLNKVAWKL LQACYTPSVS SPPSISALRA PISSLSNAWA AVVSPGVSGL
GAERLGRHSR SGEERRRGLS RSHSSSLRGV LTTLVRQLFD RNSRLHFLPE TSWILPDTMY
LLKSKALLHQ QERLAQLDAS FAPPPRAEEA ATEGLERVAN TGVKHAEKIL AALLTELPHT
MAFEDRVLVF YDKINADRLR FRDAFHQLPF DRSLHEIRRG YIVEDGLFAL GYADEHDLKG
FFRIQFITGE GVPEEGIDGG GLFKEFLVLL SRKVFDPDYG LFKASSDNSL YPNPSVHLAH
THPTALYNAL GKVVGKAIYE KILIEPQLNR VFLNLLLGRP NQVDDVQALD PVVHKNLLFL
KHYTDNVQNL ALSFSATLGD FGSNEEEDLI PNGRTIPVTN DSKLRYIQAV AHFKCTKQIA
KQTQAFLNGL SQVIPLKWLK MFSPAELQLL ISGSPLGFDV ADLRAHANFT GGFEASSPTI
CWLWDTLEEM SSEERSKFLM FVTSCSRPPL LGFRNLHPSF TVHRVPERHR LPTSSTCVNL
LKLPPYESKE VLRERLMEAI EGAEGFGLS
//
