ID V4Z553_TOXGV Unreviewed; 8007 AA.
AC V4Z553;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=TGVEG_295710 {ECO:0000313|EMBL:ESS29106.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS29106.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UPL family. TOM1/PTR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00034494}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS29106.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAYL02000315; ESS29106.1; -; Genomic_DNA.
DR STRING; 432359.V4Z553; -.
DR PaxDb; 5811-TGME49_095700; -.
DR EnsemblProtists; ESS29106; ESS29106; TGVEG_295710.
DR VEuPathDB; ToxoDB:TGVEG_295710; -.
DR eggNOG; KOG0939; Eukaryota.
DR OMA; NDMLWSS; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd14296; UBA1_scUBP14_like; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF446; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF06012; DUF908; 1.
DR Pfam; PF06025; DUF913; 2.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF14377; UBM; 3.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 2250..2299
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 7761..8007
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 205..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1664..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1865..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1963..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2226..2250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2302..2455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2585..2621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2678..2763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2894..2955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3035..3062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3171..3272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3354..3390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3437..3468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3591..3734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3839..3896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3979..4010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4040..4067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4112..4165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4477..4695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4753..5165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5378..5428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5450..5499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5555..5790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5838..5902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5927..5952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6002..6038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6057..6098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6163..6218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6668..6776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6804..7003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7057..7148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7294..7381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7483..7558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7616..7670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2150..2169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2313..2332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2364..2405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2440..2454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2603..2617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2682..2714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2933..2950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3222..3242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3354..3373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3446..3461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3667..3694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3705..3727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3851..3865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3874..3892
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3979..4003
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4480..4502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4527..4554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4600..4644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4753..4799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4800..4903
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4929..4954
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4966..4991
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4996..5012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5013..5030
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5058..5072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5085..5123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5143..5165
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5378..5399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5461..5477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5565..5580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5592..5614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5692..5710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5717..5781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5931..5952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6058..6084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6668..6764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6804..6864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6961..6977
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7063..7078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7090..7106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7294..7309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7310..7325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7483..7540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7623..7638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESS29106.1"
SQ SEQUENCE 8007 AA; 841316 MW; 88A081206C660795 CRC64;
MGKIPLSLSD NFQLAVSSLP ETQRQLIEVL SSCPDEELLH HLQPFRGWMW EKQGDVTAWA
PALNRFDDLM VAYARHKGLL AASEEKNASP TPHGDSPKAF VPSDELVLAV LETSCIVLEN
CSSKCLYSSV DVVTSLVDAF YLPIVCSAVQ VLAVCYGFVK RNRRTGLPRE CPELTARLPL
LCESPVAYDA FVLTRQPDRS RIQLPGLLYD SGDSSPTETP VGSGDPAARG PGQRRDRERD
REAAVGRGSS RRLQRGEEPR LPGESRAETD EFSVSPRRVD PLTFYLAERF PLDFEGFAEF
QIIVTSAGAG TPTGSPLVTP AEVSPHLSGL AGREGESHET VPKKPEPSRE AAAASAKKDE
YSAPRVKTVR IPCVELMLPE ASPEDGGAEA SALGRRASKD TGALEALFDS VVKKYGIPPQ
HFTALRHKIR LLHGLQSASY RRELLNMQLS SLSCLLVVNP TLFSSFVASH PFFFIDFLRL
LKHHQKLTPR TMLLCADLLS VLLEERNFYK QLAPTLGLFS PHGLFLSILR RLLRHPWASQ
PLRVKREFLP FLSPALQPGA GAGGDVLTGE EERGRDNAED AHVDKESCPQ DVTMEEAGDP
GRATASQEET QTATATAEGG DAEMGNASGK EEKRDEVEDS EEARKSGEEP QAGRIVYTVL
GEPEAERRLR DWRSRLQETG VQKLQDDMDR MQTLLHLLAA YASIIAMNNH TIPAFVQPSL
LAALVGFLRN REPLVIPVQL FAVRAIEALM EQQQHSSSSS VILLLQQDLE LARRFEERIL
YDAACLVQRV QFGICDGPEP SPKKRELRPA KNGAAGEAAT GQEALEAGGP GRAGASGARE
EGDADMTERE DAAEVANSAE NDILEASRYP AGGTDEDRAC YWLSVCEVET RRCLLKALLK
DFYVMTMRQG LHTAALGNAR QPPAFLDLFT ETSQLTALCK DIILLPQWFG LGCVSSLLTS
LSEVISDDPL CLSSLSSLGL VPLLLSSLTE AHLRNDQVLG SIGPFLSSLV LHPTGVQLLQ
RARPCGLHLS SNAPSPLPLP APLPSSLPSP LPSSPSSSLS LSLANNSVPS CAAASVPSNA
SVSTVGGVVL AGQALEVQRA AKALEKQVAN AGNRNAADAD PADQTWSVST LLMRATAAPQ
AVLLDRFGES AAGLGSSLDE VLRSVASAVS SSSAASDTCT SFVEHLLVLL RHLERHERRL
PLWQPVPPEE GERRLEASKH LRPLLLADLA LPPAPPSLWL ADRLANVGKL LGTFLQNSET
LRCFIAKGGV SLLLSLCSSP SLPPAFLHLY PQHPLVVTLR YVASASFSLP HLLLQLLLLS
RATKSTEKLG DLAETWTLDR WPASGGVPPA LMFRTRHREA DKCLSLADKK ALIAAVDACS
SALQVAAMLG RELGQAYSVG LTTRFASNHQ LFLLQHLGLL LLQLQRVTPF ALRLLYATSP
PLADAEGTPS LLSSRHNAHE HPAVRASKSL AQSNKLSQAV TSDSLILSSN DMLWSSLVEY
AYSVPPDGAA AEGGVEGEGE RRLAEARVGG PDAEAEGLET QGRQLAEAAK RGERRENRGE
RTVDMEEARQ EERGEGKARE DGHPRISRAA AESPIVLAET LRGMLQTVRA IVVNASRMLN
TNAIRSKGGT PQQQQTHLQV ALLHCLSIGL QCRDLLRPVP SAPLPTRLLC PFEPETESES
EASTAEGEEE GREREKEACG RPRRRARTQR KEGGPSETEQ PETGNASPEV VIDGLGVIST
LAYICDVLDW LYKLHVDEKN RGLLLTMTFD AFHKVGGVTE LMRVVDYAFA VNLTVHCFFA
QRAFAGVCGA EAEGRETPEK QASPLSLEAL LPLFLFEETR RRRGSASVDD DSEVSLLACL
GKSAADEEDT KGEKRGNAEE GQAKDSEEDA EKRREAFLCW MRELMKQFEA LSDKDMKTVR
DLASKCLQCA LAYCDKATSW KRCLNSPVSQ FLQGNLERPS YFQRMQESQG SRSSDSSSAP
TSSSGASSGA SAALEARETK PEKGETQASR SCGDEGAASA RATSAPTGEA PRPSLRFSYT
PEGIYQAYLR LQENGENGAQ APEAPVRLLP HNDFRTCDVV GLLRSVQCEA AAHVLVWWSL
AAKCGASLRL PDDAAMLAVS TGALGAKGPA AHAARRLHAQ QQVAEAFVAA SRHKGDRGDR
KARRASEEDD VEKYVSERDW LLGPLLAPFL QRVTGFAHKV TYHLFDTMTP QRRAWIHSVF
MDLPPPSRTG PASSTGTSGR ASGGAAGRGS LHARRAAVLR AAMVEQLTEM GFGESSAQRA
VDATNGRSIE LAMEWLFERQ REEEAAASTA PSASAGAAAN ASSESTGESA DGARGSASGE
PPTADSFEAS GRGDAAPADG TQRTGASGAE SGSTTSAGTV LASGTEAESR SEGHSQTNSA
TGSGSADGEA PAAALASALT AETGRDTGAA VRARDSRAET RLPSGTQPAS LGSPLASSRA
AAVAAASALM GEVGPSFDYF GAFLLPSFSA DESVSSSASE LANVTRALVA AITGGPGASG
ANGFGRGLSS AFYGLGSRGR SSGGGDRGTG QATEALFFVA ASASLAGRLD LDEAWAGGSR
ERLLAEETGG EGTGVSAGDA AGAAEEPRKE DSTRKTGSRT AVWEGPISAH ISDQRALEFS
EKIRRQIVPQ LLNLVCVLPQ SAASLCEALM KLLGAPVDLS VDPKRGRPES GVDAGEKRQE
DDPKRRDSKE AGPGESGPEP DTAQAAAVDT QEGKAEEKPP QQEGSASNIS KGAGEKSATG
DDLEGAPLSA AALLQQMGER NLFVTMRLLT TRLLHLRQLC LCVPELAFRL PALPAFFCAN
AKMSTAPDAA SEDVCEPGTV SKMWGFRAGL LALRLQQQLY GTCLLLAHLL HRKRHAKGML
LAVCHAAAAL TRRRTPADRD EALPGKRGPK AGQTPGARAP AAGPAAPLAK KSERGGGPDR
RLHAPEKGRT GGAGREAWLG VTATLARNHP VGIFWKLIVS TLSEEALLAS AHPFYLSETK
GVFLIPQLFR ESLGPSSGGA AHAVAEAAAR SDASFAREPG VKLEAGDAKT PSESPEGPNP
VSTPVLPIAS WCLLDLPASP AAASSSSAPL MTDAKVASIV PFPSGPQIHP WCCHSSSCSS
CSSSPSCAVS SSPTCLAAAV PAASRPPPFI LPALLCIQEL LPLYLLHERP ATSPGLSPPT
HAPGAETGGE THRGARYRGS SRSAPAGPSE KGKAGRHAAA SSDSQGGANA STSGSQNAGP
LASAGGTGAK ERETPSGPEG EGSSLTSGSP GRVLPIHEQK QMVAGCLDLL HFYPGIDGDT
TLAVLQILHH LTVVPANALH LLLYSPKGSL LSLPSDVSGG DTGTDSRRRF EALKGVKHEE
SREDPEDAVM GEEGSGDTKS GAPLTASSLA SASRASRTAL GAKTGSCKVP ALPFFSISAT
LAHATSSVEM QAALLPPPAK LEASGTERPV EMRREDAPRG PSGERGGNLG GGLGLLLSMP
RTAGCNGMLT LIQQIVSHAC EEQSVLAAFI ENEIRYLFKR AQLASRTLYR RVHGAPPPSA
EEEENLRPLV PAEAILETLH PFVQRTPVLV EQILRGCCQF CSTACASREQ GGEQTEPSEE
GLPGASSKPP VEDSRPETQA AGGSASHGSR NEEKRSPPSA SVTPGPEGER GRTPEAMKTT
EEQAASASVR SEERKTGDVD VHMESEEGET CAKEGAGSKK IGSGEEGPPS DEGREKTAEK
EEAEKVSPPA PPPEAIPCGI YVGHKKGFVF RRGIQGVGYY PEAEGEKHTD GGERSEPVVL
LRWLEDHERA QTLPHQKKVK RLLLQARKSP NVAALLMGVL TDYSVLFLNV EAMTRLASAP
LQQQPEQGEA KASELGDKKP LDGDGSRDST AGPGGEKPCE KRKGEQEEGV SRAWRNLDSV
LHPPGVSLKG DTEGWASNVR PMYPFALTAD SLFYIMIQLI SSYPSVLPLL CKPMPLLSAP
TPATASACAF EVLQEGRAGR ERDDGAAVPT RGEDKEGIEG SSEEKCKPAG AFSIPKPLPL
HKLRGGSGHQ AGTLDSAASV TNADLSGPGR VDGMHAPASG GGSAAPGTPS AEMIRLYLPQ
PPPWVFTSSL PSLVGEAAAT PSGFDLSRIL HSHHGQVPGG AGERRSSGLA RGEKKAEEGP
PAQATAGSLT ARSGGEEEKE TDFASFSAEP SDASVSCGAA PVAQVGACAP KGLCSSSAPV
RPLLDYLLRD VLSRLLTLTL PPFACTDKTY AAALELQREK KLSVSSLSLG SSPALVSLNH
FLQLLGAMAC CSLDIRKVLF QQVSGALASL ARGVSFASNP ALLSRTGRER RESSGDVFDI
DQEVLRSQQR EHIQLLAAEE QRGAEGTDCY ALAAAVASAA ATGNNARGFG LKDARRGASA
HAAHAVHGSH LGKAAAAGHL PGGPGALAAS ASSVLGAVAG STRGGEKESR EASASSVVLL
QYRLPADLQI TAFYTLSSLL YRLFTLPKEL PPNPLLLPLS STAPPTQNEA NPEGNSSSGI
PRGCGVSGPL PFSGRGGRKD DDEADSGNSS SGGPSGGRSG AGASSTSSGT GREGRASGAS
IAVRGRVASL AENGETVGGE QEPRDEAAVA ARVSDSGLPP TTWLAASRNQ ASSARQQGGS
GRPASGSRGT TNESRSSAAR SSGASASGEG EGDPPKGPSA GNLFSGGDCK NDASGQGSSA
PRPGPTAPGP SLKSQYGLSL DDLQRLRDSL SLFLFQLPLH SEDAFVSVTI AVRCLTFLTS
PELLGLPAVS RDASKDRLRG RGAEGRGKSR GTRGGAEEED EEARRRRERA RRVRRASEME
DDEEDEEEEG EDDEGDGEED DEEDEDDEDE EDDIEQDEDE DDWDIEEEPE DEDGEVALQC
ELFDLEDDED EDDEDDEMGG EDDDEAVGLT DEEDVDADSA DSEDEAPAAA GAGLTSTREL
PHEVEEEEEL LRETGEVEEE EDEEEDEEDD EDDDAPRIRE RGDLDYEELL DEEDEDDELQ
PHEEEALMED DVSDIVSSLT GRRRRDTGDG DSSPDASSDE DHEDLGDGQD GDGPDSASEA
PDQEDEISSA SPLEGAATGH GASSSETSGS SAPAEGAAEE DSGGGQGETS RSRLRFLNAT
TEDGETGLAS AFASVSGASS ETRGRLPGGS ARRPSSSLPG FSPDDMDDDD DDDDLDDDEE
DDDDADDLRF HFHLSADAHR ELVSAVRGVV SGGRRQGAAR DGFDDEFSVD VHLGPQRTGA
SLGRVSSGAG GAVRGRDAGA RGLVGAASNF FRTPGGDSAG LGNGGAHFFI GRGSGFGAQG
AGSTRSPFLA SPQASGFAPF LGGNSAGGSV FSLFAGPGLG SILDVALGAG AGAQGTGAAH
PTLAALTGQT GYQQTWTSWD VSAIPSEHPL FSSSLCRASH SNGASTPASP LQGTSASASG
AGPERGAGSG GFGARASGGR PSGSGRDGRI NERFLIQHLL EDLSQAFGSE ILRTPPSGGA
PTARRLTSSS QNLESPRHQA GAAGAESHPS REARHEYEGR DDGAGFEALY GNMNFFEEVE
HAHQQRLAAA AVLSRLAVTG TGSGAFLSLD DVPFPVAAPT QPEEPDSREA GEREEMEAAA
LEADQAEEGE EASTGEERPG EERPGEERQR TDTTTGAEGE PSSEEARRAQ ISVASTPHSD
RPEGTALREG TVDAGVLPGA SVEPAASAQR EEMEVDMEAA PAPTPQAPQR ETVEERSPET
EPRDAGQAAE ESGDTHLQGA IQASVETDEM PSTSQDTANA NEQPPTSDST SSSSPSSASS
SSSSSSASSS SSSSSSSSPE EGGGPLAPLA RALGLTEAQL FDAAGMDPSF LEALPEDLRE
EIVVQQLRQL TIQAVEQRRS ENESLCSAPP SSAGEEAPRA TEAESAAATH AATEAVVGGQ
PAEASGPQPT SSSRRPGGAP PLSEIRREYL SALPSALRQQ VIAACRANEE TSGDSGAQQR
ASTSQEHSDA GTDLDNATFL ATLDPALRQE VLLTAGSDFL RTLPTEIMAE ASLLRERVLQ
RSQHARSARD RGAAAQGGRG DGDRARGNAS AHGRGDRDRA GLQHFLGFIR GNNGGAGGAA
TAGTSSQTGA SSRSRSSTGA GASQARGGQG AGSGGGAQAP IFSFGTRVGF EGTDNLLGER
GNGDLYLAGL FDFLDSQILQ GGTLEESGRA GLGRLQSRGS APLFGVQSFP SPSAEDGLGA
GGAGGRGRSM DRDGAGFLGT RGGVRGAGPP EARNLSLGAG NPLLQESAVL SGTPASPAGA
ADPLSLLRGS HAPVQRAFQG ADRTPGLSSN SALERFLQGT WAAIAAAASN SNSFGGVTIS
GIPSSRSALI VNPNSGTYPL LVGAGLAAPG SAGAPSQGSG AGAQLGSSSG FFGGSVPGGA
GTQVNVLLTG GLLGQGGGNL LSLLSSSIRG AGARPAMVAG GRDMLGNGLS FSGTSGGGLS
GTVVTRPDGV VDGLSALNEW LLLSPSVNAA GHPSSFAGAS GLQTDGGFRG GATSRRGSDG
GYEVVARSPA GFYLHGGSPL RGPRPPFHPL GVLGICRLFY LRKEINRKLF FTLLCNVASA
HQDAWHLLVL LFLVICWSAA PDCHQPESSS ARSSASSPPL SSVGFPPSAL YGALFEGASS
NAVALFERPS AAAVATERVL EQLRSLLTVL PSASAAFAHR MRHPQAVSLR DVAYPSSLSA
ISSLFGKKDE KAPRVASAPH DFGPGRDEPK KGEDKKREIQ GKGGAGRSRG RQGEDDRKPL
EEPEKSGGKK DGANLAKKEK GSRDRGAAAE RGDGEERGEA THGSDATEES ACAAKPRACI
ERKEEAAAQN GYIAAEKGRE SELFASAWRR RTGGGTEEDG RSRGREERAA TLGGRGACDD
EDALGGSRRS GSGDGEDLVH ELRRKKKRRE WNGAALSFGI GSSPSASALS PVGVQPGGGE
KEGGEKETGR AGTAVSTDGQ CLPEGVGVKK EPEGGALAPR ASFGDPAASS SRVIPGTNER
ASQMRERREE EKEGKSAVSA GRMVPHEKSG GSSGSPPGKD DEKKIVFGEG IKEATLEYPI
NVLMTLTSGT LFQSSPRLMN HLLSAVYFLL VGGDGAGSRE GEGSATKASS SQRRSGASAS
APERGDSPGV TGASESSGSP PVETVSSGAP GVSEDAGAAA PTVTVASKPR PEETGSGAVS
ASGPSPEKEN AMLRVVSPTA GRALCQLLCS PSVAASWSQG AHTPQQREAH QQQLNLVAKV
VGCLYSSTQH RAWVEEALKQ NATTLSRGIS DELRLLAETM RASVRFLGRD SGSPEPALSP
HDDLWRRRDL LDPQLAAFNR LCSTLSDVLS QIEEQAGGKE KEREQERAPR SPTSQGNNAS
AVCRASRAPS GQEAEMRETA APGSSSSAPT PGAPEGPPAA STSPERSEKG GGSAGSSEAR
DTALQSLEAA ALEAIESLNT VAMSTASRQT GARASGGKRG EGAESRERVS SALVAFRNFF
DQSGVALIWE QLDDVLTAVE ECYPSLTMQV AAPGLLPPRE ARRRLPAAVR EGDEGEARRE
EEDDEGRGSE GRRRRVRREE ELEEEEEDGR RREDAEASGL VDGGREVWPA SAAATSAPTD
DAAPLILSQL LPILEAYLQV HQTCIAADYD VKEVADLGQL DLFSLASEAA NAPCMKVGTP
DSMASPEDEK RRTTTQEDAL SPRVDSRAAG DTGQLAPLSP SAHASAATAS PSQRHAELCC
FGERHKASIN ALVKQTPSLL TTTLQPLLKL APMTVAFENK RLYFRHKIRE MRQSARFETI
RLSVRRDQVF TDSYHQIRMR SGEEMKGKLN VHFTGEEGVD AGGLTREWFS LLARDMFNPN
YALFRREGAK SEFNHPNPLS SINPEHLHYF KFIGRIIGKA LFDGQHLNAY FCRSFYKHML
GRRCVTADAE SIDPTLYNNL LKMLQYSLED LGLELTFSTE VDEFGMHRIE DLIPNGRTIP
VTDANKHLYV QLICQRKIVG GIQQQLEAFL SGFHELIPPA LISIFDDKEL ELLLSGLPTV
NLEDLKANTD YVNFLPTDQT IVWFWEV
//
