ID   V4ZH75_TOXGV            Unreviewed;       759 AA.
AC   V4ZH75;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=GMC oxidoreductase {ECO:0000313|EMBL:ESS31667.1};
GN   ORFNames=TGVEG_243655 {ECO:0000313|EMBL:ESS31667.1};
OS   Toxoplasma gondii (strain ATCC 50861 / VEG).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS31667.1, ECO:0000313|Proteomes:UP000002226};
RN   [1] {ECO:0000313|Proteomes:UP000002226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA   Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT   "Annotation of Toxoplasma gondii VEG.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00010790}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS31667.1}.
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DR   EMBL; AAYL02000165; ESS31667.1; -; Genomic_DNA.
DR   AlphaFoldDB; V4ZH75; -.
DR   STRING; 432359.V4ZH75; -.
DR   PaxDb; 5811-TGME49_043650; -.
DR   EnsemblProtists; ESS31667; ESS31667; TGVEG_243655.
DR   VEuPathDB; ToxoDB:TGVEG_243655; -.
DR   eggNOG; KOG1238; Eukaryota.
DR   OMA; AEPACKD; -.
DR   Proteomes; UP000002226; Partially assembled WGS sequence.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.30.410.40; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT   DOMAIN          179..193
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00624"
FT   REGION          443..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..458
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..564
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  83611 MW;  39CD7DCEDAD45F9C CRC64;
     MPQDTQYVSR LAMSLQDEGY KPLFPSDERA KDFNCPRSGL GCTAKILPGH VWGGVTVFDK
     EKNFFRNAAD VFVYEAPGVP AHPDRLLVKT EQFVERVLFA TSKVSQPRAV CVSYRPSSAE
     DMAPIGLDAP PPQKTGESRG LLSSLLSYAL QMLEWIWPND SSLEIACLRG QGEIILSAGA
     VHTPLLLFRS GVGPQEQLQE IGVPAVAVVE ELGRNLSDRI LIPIQMFQKD NKRKEDRNPR
     VCQVLGARHQ GPHCDGVGIN ERTLKCSLLT TEELSGPNVI HGLLWASHLL LPPSWRDHPA
     AHAVFNFVRF CEGKMKFQGT LQYPPACMFV EGLLDCLDRS ISLFYFTTEP KSRGYIRQHK
     DGRVEVEANY LKNEQDLFDA TRGVQSLIQQ VNGGRFADIV EPLQPGSCPV LMLYTVVSLF
     LDFAQAADLP QYEKQLLSVR RHSTDLQTHH HEQARATMPS ASEDELPFLR LIQNLTESRG
     GLKNEKQPSA IRAAANDPER SEGAAAHGTA AQPAEGFEED LGKVFKDREK LKRLFENGSA
     QQRRRQTNML PETTKQSSQK KDELAPQSRV CAADAEPACK DGPIHSDVYT TTCSAHDIFT
     KRYGSSACSS SPDASTAQAE SPESFISWQA GLAEAGIQQF FGERLPPGSG QWAATYPPVL
     PQVDDPEAVA AFAVTYMTSI WHLAGTAAVG HVVDHEFRVM GTKNLSIADA SVLNQMTRLN
     PTATLLTLGR YIGLLKVKSS ERNTNNDRKS GEHGRKGGL
//