ID V5ATX4_TRYCR Unreviewed; 922 AA.
AC V5ATX4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS55533.1};
GN ORFNames=TCDM_12989 {ECO:0000313|EMBL:ESS55533.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS55533.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS55533.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS55533.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS55533.1}.
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DR EMBL; AYLP01000785; ESS55533.1; -; Genomic_DNA.
DR AlphaFoldDB; V5ATX4; -.
DR EnsemblProtists; ESS55533; ESS55533; TCDM_12989.
DR VEuPathDB; TriTrypDB:TCDM_12989; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 93..440
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 97434 MW; 47B158D6697FFFAD CRC64;
MLPRVAAVMA PRTHNRRRVT ESSGRKREGR ESEPPRPNMS RRVLTSAVLL ILLVMIFCGA
GGAKTEEDQS SDPNFKWTDI TEGEGETVDS LGVPGLLKVG SDVFAVAEAH CKKDGETSVF
TGIASQLLSN TADNKPEEVL KNAKDTQVLE KGGSKGKKKE VDVSRPTAVV KESDIYMLVG
KYGGEGDAAC QGASDVAPWG LLLLKGNVSD GESAKRILWQ NTYGLPCIFT VEHHASLTGL
IAGGGSGVKM NDGTLVFPVE ATKKETNNED EVKTTTVSLV LYTATGGGNL SKGMSADGCS
DPSVVEWKGK LMMMTACDDG RRRVYEIGDK GESWTEALGT LSRVWGNNQK RHEKGVRSGF
ITATFGDGGK RNVMLVTLPV YSKKTEGVSA NGKGVLHLWL TDNTHIVDIG PVSGEDEDVA
ASSLLYKSET NEEKLIALYE KRKGAGEKPS HSLWTVLLTE QLQRVKEALA TWKEVDERVS
KLCPSENAEH DSSTATACST GKITDGLVGF LSGNFSDGTW KDEYLGVNAT VNKGAEEGAA
AEKADSSDGV KFHGAWAEWP VGKQGDNQLY HFANYNFTLV ATVSVHEAPE GNTPIPLMGA
KINDGDNNPV LLGLSYNKKE EKWILLCGGQ TTTEHSSHSE TDNAQYQVAI VLQNGTQGSA
YVDGQRVWNA QCELENTNSK GISHFYIGGD GGSAGNTAGD EGVSVTVSNV LLYNRPLDEA
EITALNAKLS IPKATEAKTV KVTPPEVTEP ATLKTETMSI LGEQQQTEQD PLGTSENAGS
GGLFLSGLPT ATNSTAAKES EDQSASGTSP SGNKNVDGTP SSDADPAVVT RSGDTVQGGG
SPQTPEESVS SGEDGVTAEG TDEQGEEGIH SQNREVNATA LNSSLGNLSQ GNNTDAGGVR
GSGLLQLPSL LLLLGLWGFA AL
//
