ID   V5B561_TRYCR            Unreviewed;       654 AA.
AC   V5B561;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS61092.1};
GN   ORFNames=TCDM_11340 {ECO:0000313|EMBL:ESS61092.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS61092.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS61092.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS61092.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS61092.1}.
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DR   EMBL; AYLP01000340; ESS61092.1; -; Genomic_DNA.
DR   EnsemblProtists; ESS61092; ESS61092; TCDM_11340.
DR   VEuPathDB; TriTrypDB:TCDM_11340; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          97..461
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   654 AA;  71493 MW;  9934005680669995 CRC64;
     MLSRVAAVKA PRTHNRRRVT GYSGRRREGR ESEPQRPNMS RRVFTSAVLL LLVVMMCCGT
     GRAAQAAEPT PGQGSSPSPS FVWRDKNDNE AVDSLYAPSL VEVNGDVFAV AEAVLKKNEN
     EKTHFFTGIA SELLALSEKN PKELAAANVK TKILENCSSQ EEGKCPSQST KQDGSQSEMK
     VYVSRPTTVV KENDIYMLAG TYIRENFAVC QGGPGAASWG LLLVKGNVSD TEGKEIVWED
     TDGLPCTSIV GLHKSLTGEI GSGGSGVKMD DGTLVFPLEA VKKEEDDAEK NGKNKNVSLI
     IYFSDTKNWT LSKGMSADGC SDPSVVEWKE DKLMMMTACD DGRRRVYESG DKGDSWTEAL
     GTLSRVWGNN QKRHEKGVRS GFITATLEDR NVMLVTLPVY SKKDDTEVNE KENKKGELRL
     WLTDNTHIVD IGSVSGKDED VAASSLLYKS GNNKELIALY EKKGAWWQSP GMVSVRLTAQ
     LKRVKDVLTT WKEVDERVSK LCPFSSAAVS KSTDTACTTD KITDGLVGFL SGEFSGDTWK
     DEYLGVNATV NNKAAAEKKD NGVTFKGRGA WAEWPVGKQG ENQLYHFANY NFTLVATVSI
     HGEKKRDTSI PVMGVRADSD GGTKLMELSY GSGKKWQALC SDGTTXXXLR LCEA
//