ID V5B8M5_TRYCR Unreviewed; 869 AA.
AC V5B8M5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE SubName: Full=Intraflagellar transport protein IFT88 {ECO:0000313|EMBL:ESS64004.1};
GN ORFNames=TCDM_08032 {ECO:0000313|EMBL:ESS64004.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64004.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS64004.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS64004.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS64004.1}.
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DR EMBL; AYLP01000104; ESS64004.1; -; Genomic_DNA.
DR AlphaFoldDB; V5B8M5; -.
DR EnsemblProtists; ESS64004; ESS64004; TCDM_08032.
DR VEuPathDB; TriTrypDB:TCDM_08032; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44117; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR PANTHER; PTHR44117:SF1; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR Pfam; PF13174; TPR_6; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 4.
PE 4: Predicted;
KW Cell projection {ECO:0000313|EMBL:ESS64004.1};
KW Cilium {ECO:0000313|EMBL:ESS64004.1};
KW Flagellum {ECO:0000313|EMBL:ESS64004.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 316..349
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 564..597
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 598..631
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 698..731
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 799..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 99011 MW; B8033C0F4B45FEB1 CRC64;
MYVCMYIAFS FRTFFSFIWK KKILYIFPCS RFVFIYFLFG FGSRGHGRLK PVSLPQRGWG
IGVSTTFGLY TFTKVNFFFF TASKAMEFAS NDGAEEDLYA AFEPESENAF TASPRNYVSE
THEVGGGGAV NPLMQAPPSR WGATSIGSAW GVPGSRVGTM GGGVGAARPM TSNRGVGFNA
AFTQFNNGAI FDPAGQGRTA MAMGPAPPLK KRGENSPEEQ CAEVEKLIHK LIEESAMLAL
QKDYGSALEK AKEASKKERQ LCKQREQLGL ADQINADLTY AVHFNLAVQY QNHQLYTDAL
NTYSLILRNL QFSQAARLRI NMGNIHVAQG RYLLAIKMYR LTLDETPTAS RELRHRLLRS
IGNAFVKLGQ YRDAVASYEA IMEGNGDVNA GFNLLLCYYA LGEPEKMKRT FQKLLNCKPV
GIEDEDDIDE KKDVLVDDAL CKKIKEDRSH FLNCIMTAAR LIAPVIEKDW RAGYDYLIER
LRHYEMRDST SHVASELEMC KCLYYLKHKS YKESIDGLKA FEKKDKLLRA RAATNLAYLY
FLEGDHENGE KYSDMSLESN RYNARALVNK GNFLFMKGSY EKAKVYYNDA LAVEADNIEA
IYNLGLTAKR LGLYEEALKM FKRVQSLVDS HEVMYQIADI NDLVGNPNAL EWFNRLIGRV
PTDPNILARM GSLYAREGDD SQAFHYYLEA YRYYQVNMDV ISWLGAYFVK NEIYDKAIQF
FERASQIQPL EVKWQLMVAS CHRRRGDYIQ AKRLYEAVHR KYPENMECLR YLVHLCKDAG
LIEEANEWFK KIKKLEQRQQ EETDEGGYRD EDEEPKGGTH AAAGRRAVSA LTNRVGDMMR
EDELDEPRIS LSEEKPTHED DDEIDLPGI
//
