ID   V5B9N7_TRYCR            Unreviewed;       881 AA.
AC   V5B9N7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS62742.1};
GN   ORFNames=TCDM_09551 {ECO:0000313|EMBL:ESS62742.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS62742.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS62742.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS62742.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS62742.1}.
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DR   EMBL; AYLP01000163; ESS62742.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5B9N7; -.
DR   EnsemblProtists; ESS62742; ESS62742; TCDM_09551.
DR   VEuPathDB; TriTrypDB:TCDM_09551; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   InterPro; IPR021287; Trans-sialidase_CS.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF11052; Tr-sialidase_C; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          89..436
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          763..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        773..818
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        837..852
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   881 AA;  93334 MW;  4F871F478372ADF7 CRC64;
     MLSRVAAVMA PRTHNRRRVT GSSGRRREGR ESERQRPNMS RRVFTSAVLL LFLMMWCGTG
     VAKAEEPSSF PKFEWKDATE GVTVDSLGVP GLLKVGSDVF AVAEAQCKKD ENSFTGIASK
     LLTLSDEPSK EEFDATQVKT QVLVECSSDD VKAGCRVAVE GSSSPNEKIV DVSRPTAVVN
     GSDIYMLVGK YCREGVDNCQ AGTENIKSGI LLVKGELGDG DNKKIDWKTT DGVPCTLGEQ
     QKTLTGLIGG GGSGVKMNDT ILFPVEGTKK EDGAEEDEKT VSLIIYSSDT PSCTLSKGMS
     ADGCSDPSVV EWKGKLMMMT ACDDGRRRVY ESGDKGDSWT EALGTLSRVW GSKHEGNVKG
     VRSGFITATI KDRDVMLVTL PVYSKGKEKG ELRLWLTDNT HIVDIGPVSG EAEDVAASAL
     LYRSGDNNEE LIALYEKRKG DEEKPSPGMV SVRLTAQLKR VKDVLATWNE VDERVSSLCS
     SESAMEDTQT GAACSTTVKI TDGLVGFLSS TSTDDKWKDE YLGVNATVNK NEGKVASTEN
     GATFTGAWAE WPVGKQGENQ LYHFANHKFT LVATVSIDGV PKGDTTIPLM GAKMDDDKTV
     LLGLSYNSQN KWQVLSSGTV TEGQSSDWDP ETQYQVAIVL QNEKQCSAYV DGKLVGSAQC
     ECENTKDKEI SHFYIGGDGG SAGGQEVVPV TVRNVLLYNR PLSSEEIAGL AKNKITIPKL
     EGPTTLVVDT QLPAVSAPDV EGTVTHSPPS GPRQMKQETL KANVGGGAGG VSGAASVNTT
     PSSDASPTVA TGSGDTVQGD GSPQTSEVSV SSGEDGDTAE GTDAQGEEGI NPPAGEVNGT
     ALNSSLGNLS QGNNSDACTV RGSGLPSLLL LLLGLWVFPA L
//