ID   V5BBA3_TOXGV            Unreviewed;       715 AA.
AC   V5BBA3;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase {ECO:0000313|EMBL:ESS32775.1};
DE            EC=1.17.1.2 {ECO:0000313|EMBL:ESS32775.1};
GN   ORFNames=TGVEG_227420 {ECO:0000313|EMBL:ESS32775.1};
OS   Toxoplasma gondii (strain ATCC 50861 / VEG).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS32775.1, ECO:0000313|Proteomes:UP000002226};
RN   [1] {ECO:0000313|Proteomes:UP000002226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA   Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT   "Annotation of Toxoplasma gondii VEG.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS32775.1}.
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DR   EMBL; AAYL02000128; ESS32775.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5BBA3; -.
DR   STRING; 432359.V5BBA3; -.
DR   PaxDb; 5811-TGME49_027420; -.
DR   EnsemblProtists; ESS32775; ESS32775; TGVEG_227420.
DR   VEuPathDB; ToxoDB:TGVEG_227420; -.
DR   eggNOG; ENOG502QPIQ; Eukaryota.
DR   OMA; EVVCEAM; -.
DR   Proteomes; UP000002226; Partially assembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:InterPro.
DR   CDD; cd13944; lytB_ispH; 1.
DR   Gene3D; 3.40.50.11270; -; 1.
DR   Gene3D; 3.40.1010.20; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain; 2.
DR   HAMAP; MF_00191; IspH; 1.
DR   InterPro; IPR003451; LytB/IspH.
DR   NCBIfam; TIGR00216; ispH_lytB; 1.
DR   PANTHER; PTHR30426; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR30426:SF0; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR   Pfam; PF02401; LYTB; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000313|EMBL:ESS32775.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  75406 MW;  403A015BA087CBD9 CRC64;
     MHTRGEMQMS VQLGGGEPDG GCAVSREIGS PHDVETSLVL SSSSPPSLRD ECESFPDSQL
     STTALVSLPH THASSMRSSR CLEANPTRGW TLPSVSPLSA PSSPSSSPCS IASSSLCSSS
     LSSPASSSPS SSLSACFVSC RSSQSPSFSP SFCLSFPPAV SLSFGQLLSL LVLALILLFP
     EMRGGPLCSE AVLHHFARQA APEVSRSARP ILSPDLPSAS PSSSHTSPLT APPPRFFSSS
     FSSILAPSPQ SSRHSSLSSS ASAPFWVTSE AVRGIKVACA RPAPLAFAFA PSVRVSSRPY
     SPFLGHASRS PFSFSSSPPS SSSRFGVSYS ASSACSLSPR SLRNTSPSSS LRLSSSSHSS
     SPPSPSPPSA SSPASGKEES EGISLLLSKP RGFCAGVSRA VGIVEEALRI WGPPVYVKHS
     IVHNEVVCEA MRKKGAVFVE EISDIPRGAV AVFSAHGVSP AVRAEAEARQ LQVVDATCPL
     VTKVHVYVKQ KAEQGYHIIL IGHKNHVEVI GTQGEAPGAV TVVESVEDVE QLSFSDSQKL
     FYATQTTLSL DDCGAIRQAL IEKYPKIETI PSGSICYATT NRQTALQRLA PETDLTIVVG
     SEASSNAKRL VETAQRRGTT AYLVNDPNAI DPRWLENVKR ISLTSSASTP EETTGAVVRR
     LEELGVAVVS EHEGILERVP KWKFPKNLLE AGKKKLDDTS RQTALGVETL VARDS
//