ID V5BFA4_TRYCR Unreviewed; 610 AA.
AC V5BFA4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Histone deacetylase {ECO:0000313|EMBL:ESS63103.1};
GN ORFNames=TCDM_09147 {ECO:0000313|EMBL:ESS63103.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS63103.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS63103.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS63103.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS63103.1}.
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DR EMBL; AYLP01000143; ESS63103.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BFA4; -.
DR EnsemblProtists; ESS63103; ESS63103; TCDM_09147.
DR VEuPathDB; TriTrypDB:TCDM_09147; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd09992; HDAC_classII; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 2.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF7; DEACETYLASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 2.
DR SUPFAM; SSF52768; Arginase/deacetylase; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 83..262
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 447..569
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 29..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 66523 MW; 292E0FC1AA4FCCC9 CRC64;
MSEADGARPP LPSSLPSLTS FPTILDVMMG MSSPSTPEEG AMNATGPDAK QKDGRIGRSA
GGTGVVYDDV MLQHESTDPT DYERPGRLKR TLEHLRAIGL LQCCRRISRH VARTKELRLV
HSIAHIDSVD QLEVAALLRH PETSYSVGQD LYANTSTSKA ARMAVGCVIA AALSVVRGEV
MNAFALVRPP GHHASVNEAS GFCFFNNVAV AVRVAQQELR QRGISAPRAL VFDWDVHHCD
GTESIFYEDP SVVVVSIHQH GTGRGHVLRK APTVFTDTID LDALAALMEE TTGEEATSNG
DNGHNASVGG DDWHQHQTRE EEKEEEEEEE EEAEKVQRQN PQLSPEEEGD GRKRAARRKP
VDYVKMAADL EEDDEAIARM FGISPEDLKK SSSSFSMSKS SDGGGGSSSI GSRSSSSHFS
SPHLLQKNLP GDTEGLSLDE DIENDKDGKF YPGTGHVERV GGDTRAEARG KNINIPWPTL
GMGDLEYLQV FLDIVAPVVR EYEPHIVFLS CGFDSAAGDL LGSMCVSPSG YYLLTKAVSA
LCPNLVVALE GGYNLSNVAR CSEAVMRALL ESSGTAPLPH SRMLWYQTEE LVKRIRQRHE
GYWRCFSHPE
//
