ID   V5BII7_TRYCR            Unreviewed;      1234 AA.
AC   V5BII7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   22-FEB-2023, entry version 28.
DE   SubName: Full=Calpain-like cysteine peptidase {ECO:0000313|EMBL:ESS65942.1};
GN   ORFNames=TCDM_05543 {ECO:0000313|EMBL:ESS65942.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS65942.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS65942.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS65942.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS65942.1}.
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DR   EMBL; AYLP01000054; ESS65942.1; -; Genomic_DNA.
DR   EnsemblProtists; ESS65942; ESS65942; TCDM_05543.
DR   VEuPathDB; TriTrypDB:TCDM_05543; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR015232; DUF1935.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   InterPro; IPR036310; Smp-1-like_sf.
DR   PANTHER; PTHR47047:SF5; CYSTEINE PEPTIDASE, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR47047; PUTATIVE-RELATED-RELATED; 1.
DR   Pfam; PF09149; DUF1935; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00230; CysPc; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF101601; Smp-1-like; 1.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT   DOMAIN          673..1029
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   REGION          81..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..496
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1234 AA;  138699 MW;  34B9BE6FB46F56F7 CRC64;
     MRHPHHTAVS LSPEDNGAKL ESLLDGDWSP IALSTMPSIH FSEYSHPTNG DWSNGVSNVG
     DSCNPFIPQD MVQNRLSCPR VRDAGGEDAA SVENGGKHTM PLTESFTPTE RVPAFSLTRL
     SGGRSTRNRM RIPRVVQTEV PLQSRIVKEP PSTRMKNRLE EPGPVSRLLF SPVLENERNV
     KAPPPEQPTE EDMRKSWETH SFPVSDLSQY QEPSSLSSIA GKNSNSGNDV NEHLRFVVHR
     RSGRGSLPRR SARRCTKTLF SAVEPLEVSD KNSNVSLPPL LETSPSKTLK ASECFTATKG
     TETQAILPSE TDSDLQFSVS LLEKASRDHS TAISPFDLCW AQQAESTDTA TAETGKSQFN
     GSLFSFATSN VLGEGSRLNS ETMGGDGTEK RECGPLHTAL TSDNDTRTEL PKNSDSFEQL
     SQLVKCTSDP EALHLIREHF LRNNSDPQRH AFVVLCDKLA KEMEENPGEK NARRTAVTDG
     DEEEDDKRMS SIEDFDRHDT EDDEFDDDNI RESAYPKKDP HRKYTFANPS VQGKSTSVFS
     SGMLYKILRD NGEFFFFNDT LQYVMVVRVQ CRLWGDEAID EKVVQTQMGN GETELTLAIP
     PEETCFLMKT VRDLPRVWAK GVAPPKDFVA PSVKRNMHDI DVGINNVRSK LGQWSRAGDQ
     KSLLKCCLHN GLRFTDLEFR PSANSLCRPD VDTATFSFLT WRRPVDYLML TEVGQARLFR
     RNISSHLVRQ GSLGDHTVIG GIAAVAMFPF HVRWMFRHPV SSAIGKRERE VGAYRVTLCM
     GGWWTTLLLD DYFPASXXXL KAPLFARCAV DPRRLWVSFL EKAYAKALGS YAALCAADAL
     EVLTDFTGFP CRNLDVLWSE AASDPEAAKT LYKYIHSCAR RQFLIMVYTP SSLKPSSAPL
     MDNLICPSTR FVGSGEGVSF FLPGHVYFIT ETLYCEDLDL RLVRLKNPWT WSAAGRTRRP
     FGWKRSKWFE QPENSTTMGA SSVIFQSKDE DGRGSGDGNA LKQRDLGTMW LEWSEASRSF
     EGGGACYTLW NWKEYRIRGR FCQCIPTVVL EVRVEQKAEC ILTISQESRL RRLGSARKFR
     YDAMLLFVSR HMAASNMESL ACTSSDDIES PSDGFTYTAA RDVSVRCIFE PEHSPYYVIP
     RVYHFSDREE IPFVLSFLCD TVIGGDDAQV HFRQLDPSCR VFQDMSSFTV DTELCRPVTA
     TYQCRTPAGV SAYEGQCIRQ QNWRGMRQMH SDDV
//