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Entry: V5BN57_9GAMM
LinkDB: V5BN57_9GAMM
Original site: V5BN57_9GAMM 
ID   V5BN57_9GAMM            Unreviewed;       438 AA.
AC   V5BN57;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   05-JUL-2017, entry version 28.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ESS65978.1};
GN   ORFNames=MGMO_223c00090 {ECO:0000313|EMBL:ESS65978.1};
OS   Methyloglobulus morosus KoM1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methyloglobulus.
OX   NCBI_TaxID=1116472 {ECO:0000313|EMBL:ESS65978.1, ECO:0000313|Proteomes:UP000017842};
RN   [1] {ECO:0000313|EMBL:ESS65978.1, ECO:0000313|Proteomes:UP000017842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KoM1 {ECO:0000313|EMBL:ESS65978.1,
RC   ECO:0000313|Proteomes:UP000017842};
RX   PubMed=24356841;
RA   Poehlein A., Deutzmann J.S., Daniel R., Simeonova D.D.;
RT   "Draft Genome Sequence of the Methanotrophic Gammaproteobacterium
RT   Methyloglobulus morosus DSM 22980 Strain KoM1.";
RL   Genome Announc. 1:e01078-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESS65978.1}.
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DR   EMBL; AYLO01000181; ESS65978.1; -; Genomic_DNA.
DR   RefSeq; WP_023496639.1; NZ_AYLO01000181.1.
DR   EnsemblBacteria; ESS65978; ESS65978; MGMO_223c00090.
DR   PATRIC; fig|1116472.3.peg.4083; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000017842; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017842};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017842}.
FT   DOMAIN      135    339       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      346    415       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   438 AA;  49813 MW;  32F2C94BA3780840 CRC64;
     MSSIWNNCLS KLENEISSSE FNTWIRPLQA IENEGQLKLL APNRFVMDWV KERFFVKIEE
     LTNEFSNNTL DLVFEIGSTA PSLPTYTKTV KRSEAKKVGP SFLNKMYTFD NFVEGKSNEL
     AKAASSQVSE NMGRAYNPLL IYGSSGLGKT HLMHAIGNAI LAKKPSVNIV YVHSEKFVQD
     MVKALQQNTI NVFKEYYRNL DVLLIDDIQF FASKERSQEE FFHTFNTLLE KKHQVVLTSD
     KYPKEIANLA ERLKSRFSSG LPVTIEPPDM ETRAAILMKK AAIVNVDLHQ DVALFIAKRI
     PSNVRDLEGA LRRVIANAQF TGREITIDFT KEALHDLISM RDKLVDINNI QKTVAEYYKI
     RIADLSSKSR RQAITRPRQV AMSLARELTS LSYPDIGDAF GGRDHTTVIS ACNRVKELKE
     SDVKVSEDYF NLLRTLSH
//
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