ID V5BQC6_TRYCR Unreviewed; 3738 AA.
AC V5BQC6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:ESS66763.1};
GN ORFNames=TCDM_04579 {ECO:0000313|EMBL:ESS66763.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS66763.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS66763.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS66763.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS66763.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYLP01000040; ESS66763.1; -; Genomic_DNA.
DR EnsemblProtists; ESS66763; ESS66763; TCDM_04579.
DR VEuPathDB; TriTrypDB:TCDM_04579; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 484..885
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1014..1340
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1516..1656
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 1875..1952
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2019..2278
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2294..2648
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2676..2897
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3143..3256
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3288..3426
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3433..3733
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2525..2594
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2831..2917
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3738 AA; 428922 MW; 36EC11AD56325D0D CRC64;
MQLAKFQQLQ QDHMSSMAKY LKGEWTENIC DVIRKSFTSA GKGWLNVHES KQEIYEMSKL
KKFFTTVKFM MEDTLFALVY TSLQDFTVFF EEVSEFTVNV IDMNHVENKW PGSDADDCVE
KQPLFMIDLA ERDGSFTYSI SFEDFEQTII QLFNDAIYCT DAIPQVEKFV MSQYFWRREG
EGPFLDSVKQ EEERVVLLRS RVRDALRNSM EPLRDYLQVY DDLLPLIRLD KKEFITFYEQ
QGHTTDEMKE EIRQHLKAKK VVAQKLPAYI TVGNYVVDCH SFGQIMANKE QELAKLVMEL
ICKMAKARTT YIREEFTKIV RTVEKQPQNP EKLYELKNFI LSLPERISEL SVEIEDMRQY
YNILDGFQYE LSDDESRQKW EAIAWPRQLS LRVQEVNKQL EKVEEELHAR LQKYSEDFSK
KVDALQRVVA TFSKYTDASE AEKVAAEVKV NSIEIRKCIE EARSINSDQR LFGDKLTDYR
NVFDLEKEFK PYSDLWLTTY QWQDCYRRWH ADPFDSLDPD EIESVVANAF KTMTQLSKTF
KDKNATLKIV EEIRSRVEEF KPWVPVVTSL RQHGMKERHW KGLSEKLNMN LVPGETIILL
DDIEPLLNHK DVIVAHCEVA AKEAQIEKCL KEMRAKWETR MFLIESYKNT GTFIVKDASE
IVELLDEHLN LTQQLQFSPF KAFYEESITD WERSLNLISD IVEQWLECQR SWRYLEPIFS
SEDIALQLPR LSRLFERVDK TWRRIMGTVN HQPNVLEFCI GTSKLLESLR ESNRILEEVQ
HGLNDYLAEK RQTFPRFYFL SDEELLEILS QSKEVKRIDA HISKLFEFIS RLAWNEKTQI
SGFFSAEGEH LPSVRPVVPE GNVEMWLQSV EEMMKSAVHD QLRQAFYDHT KTPRSRWVLR
WPAQCVIAVS QIFWTNGCEE GLSIQGSVKK FFRLLESQLD ELVDIIQSPL KPRERINMGA
LITVEVHAKD TVELMKRNEV SSIHSFDWIK QLRFYFDPDD ELCHVKQVDA HFVYGGEYLG
NTGRLVVTPL TDRIYLTLTG ALALCLGGAP AGPAGTGKTE TTKDLAKALA KQCVVFNCQE
GMTCNSMAKF FKGLAWAGAW ACFDEFNRID VEVLSVVAQQ VTDLQQACLT KQYRIIFEES
EVVVDPTHAV FITMNPGYAG RTELPDNLKV LFRPVACMVP DYALIGEIRL FSYGYKKARS
LAQKMVMTFK LSSEQLSSQD HYDFGMRAVN TVISAAGLNK RESPNEEEDL LLLRALRDSN
VPKFLIDDIV LFEGIISDLF PGTKVPSTDY GMVVDVLRQV VTADKLQPVP TFISKCLQLY
DITTLRHGLM LVGPAGSGKT MAYTSLQKAL SECAVMQSKR NDLSSREYMK VYTHICNPKA
VTMDQLYGVY DENGEWRDGV LCVLFRRAAK YGDEGNQLGK HWVMFDGPVD ALWIESMNTV
LDENKKLCLV SGEIIQMSRD MTMMFEVEDL LVASPATVSR CGMIYMDPTA CVPTSAIAAT
WKASLPAYMV SKNEYLTELA NTYLDKLVEF IRANLKEYVP STNIGLVHSF FRVMDGYIQS
FAVPKPQPGQ PVMSPERAEI LEKCITPLFF MSVIWSLGAT CDEGSREKFS DMLRTVAQGN
NHADSLPAEG LVYDYCFVYS AVPEDEEQPR WVHWDDLCDT CEIGRMTKFE DVMVPTIDNT
RQKYVLQHLL TQKVNVVAVG PTGTGKTVSV SDLVLGGLPD RFLGLTFSFS PQTKAGVLQN
SLMSKFDKRR SHVFGAPIGK HFVVFIDDAN LPQKERYGAQ PPLELLRQLL GHGGFYNFTG
GIRWNTIIDT SFVMAMGPPG GSRTQVSNRL MRYLNYVSFP EMSEVSKRTI LNTILKGGLS
QRGVKSEVID LSSKLVEGTL SVFRRCCKTF LPTPSHVHYS FNMRDVMRVF PMIFENDGNS
LPNEEVLVKQ WMHEMQRVFY DRLICTEDRQ QFISFLNDEL TQLGYEGGYT SLVPEGRLIF
GDFMSERERS YRQISDMNAL SIFFDDQLSA YNNANETVMD LVLFLDAIEH VCRISRVLCL
PNGHCLLLGI GGSGRKSLTR LACFLIPDMD VFTIEFTKNF GVKEWHEALA KLLLDCGKDD
KKRTFLFSDT QLVHPTLMED VAGLLTSGDV PNLFEDQDIE LINEKFKGVC MSENLPTTKV
SVYARFIKEV RSNLHVVLAF SPIGEAFRTR IRMFPSLITC CTIDWFAEWP GEALISVASA
QLAETDMKME DMEMEHLSEC FKSMHLSASE TTERFFLETN RRSYVTPTSY LSLLNNYIFL
VENKRRFVLE QCSRLENGLE KLYDTENRVV ELETQLKAQQ PILERKKTEI QEIMERLRVD
RKDAAEKETS ARHEEAIATA KAEECSKMRR ECADRLAEAE PALQEAVKVL SKIKAAEISE
LNKYQSPPKG VQYVMEAVAV LLTFGNCPRE FYTGPPGGKK TPDWWLCAKS YMKNANQLLD
TLVQPPEKGG FDREAMDMPL IEKVKGYYDN EEFLPEKVRT VSVPCMAMCQ WVRAMYNWFF
VNREIQPLRQ RLSEAESELR RVNAALAETR KKLDAVIEAV VALEREFTEA VDTQTQLEND
VEETSQRLHR AARLIDGLGG EKVRWMELVE QYKTQEKCII GDMLIAAASI AYFGPLTGPY
RRSLLDTWSG ILRGFDIKTS EQMDLVATTG DPVQIQEWQL CGLPKDPLST ENAIILTNAR
TWPLLIDPQG QANAWIRNLH KNDNLQVCKA SDEKFMKVVE GAIRIGLPCL LENVGDSLDP
ALEPVLLRNV FLIGSTPHIR VGDSAIPYDK RFKFYMTTKL PNPSYTPENI VTVSLLNFFI
TRSGLEDQLL GKTVEKERND LEQEKQKLTR DCAEKSLELK KMQENILRML EEAEGDILDQ
EELINTLERS KLKSTEIKDD LQRARETEKT IDETRNKYRP HAYRGALLFF CVSELSMVDP
MYQFSLQWFI NLVLFAVDKT EQAEDIDTRV KNLTEYFTYS FYTNVCRSLF ERHKLTFSFF
LCTSILQQEG SLNGDEYRYL LTGPTGRGGN AANPAPEWLT ENSWNEIQFI SANLPGFSGF
DKHVTENCEH YKKLFDSFSA HTFPLAEEWK NRETNMQRLV ITRCFRKDKL APAIQEFVKH
YMGERFIIVP QFDLMDAYKD STCLTPLIFI ISPGSDPMKD LLRFAEQMRM SKKMDKVSLG
QGQGRKAEEL LTNGRERGQW VLLQNCHLAT SWMPTLEAIV ESFTPETVRK EFRLWLTSMP
SESFPVSVLQ ISVKMTNEPP MGLRANMTRS YYGLSDEDLD HASKPKEFKK MVFALCLFHA
VIQERRKFGS LGFNIAYEFN DSDRNVCLLQ LRKFISLYDE VPFDVITFLT CEINYGGRVT
DDWDRRCMLG LVKTFINPSV LEDGYAFSPS GLYRTVEPFD RLYYLNLLGS WPLNPEPEVF
GLHDNADIAC AQSESANILS TILSLFSREE SGSSHTSREE MLMRTAQGIQ EKLPRLFNVQ
EFHEKYPTRY EESMNTVLVQ EAVRYNRLLR FVQKSLAEFS KAVRGEVVMS AELEAIGSSF
FINAVPASWA ALAYPSLKPL SSWVDDLVQR VQFIQSWYEN GVPKALWMGG FFFPQAFLTG
TLQNFARRTQ VAIDSVSFRF GLLDEKDPAR VESPEEGTIV YGLYLDGARW DAKERTLAES
RPKELYVEMP LIHLDPKVDY VNDPKDYICP VYKTLARAGT LSTTGHSTNF ILAICIPTNV
EPEHWVKRGV ACVVSLNF
//
