ID V5C098_TRYCR Unreviewed; 410 AA.
AC V5C098;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cytidine triphosphate synthase {ECO:0000313|EMBL:ESS70213.1};
GN ORFNames=TCDM_01014 {ECO:0000313|EMBL:ESS70213.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS70213.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS70213.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS70213.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU00333};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS70213.1}.
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DR EMBL; AYLP01000006; ESS70213.1; -; Genomic_DNA.
DR AlphaFoldDB; V5C098; -.
DR EnsemblProtists; ESS70213; ESS70213; TCDM_01014.
DR VEuPathDB; TriTrypDB:TCDM_01014; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR InterPro; IPR003726; HCY_dom.
DR InterPro; IPR036589; HCY_dom_sf.
DR PANTHER; PTHR46015:SF1; ZGC:171603 PROTEIN; 1.
DR PANTHER; PTHR46015; ZGC:172121; 1.
DR Pfam; PF02574; S-methyl_trans; 1.
DR SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR PROSITE; PS50970; HCY; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00333};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00333}; Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00333}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00333}.
FT DOMAIN 1..402
FT /note="Hcy-binding"
FT /evidence="ECO:0000259|PROSITE:PS50970"
FT BINDING 284
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 387
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 388
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ SEQUENCE 410 AA; 45150 MW; 64124F49756C2CD7 CRC64;
MSTRQVTGVL IKDGAMGTLL ESWDVDYAKA GSMWSSSVLL SEMDLVKRAH RAYIDAGCDV
LLTCTYQMHE EGCAASKMTM CELVDRAVQA ARHTMPKQKQ KGLTEESTAK ERRTGGIDVF
RYALSSIKDN GQERVVLLAG SLGPYGSSLP GGQEYLGEYS IHEAVINAFH ARRLEAFLCN
VGEKHGLKVD FLLLETFPLL DEALGILSFV NQHEILRTAP FCFSFIAAPV KNPLPENADD
DALDNWWNAA ASSIRLPDGN TFEGALSELR KNCGTALVGM GCNCSGPLEV SLVATALLHK
KRQDTEGPLV LLLYPNSGEK FTDGQWKKQP QQIQTSAAEK LSMRDLKRIL ARGGGNLITF
MKFLLQLLQQ RPEATYWLFE IIVCGACCRS TPEDIAALNQ VAREEPYLHA
//
