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Database: UniProt
Entry: V5D763_TRYCR
LinkDB: V5D763_TRYCR
Original site: V5D763_TRYCR 
ID   V5D763_TRYCR            Unreviewed;       773 AA.
AC   V5D763;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   07-JUN-2017, entry version 12.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TCDM_08916 {ECO:0000313|EMBL:ESS63311.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma;
OC   Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS63311.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS63311.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS63311.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESS63311.1}.
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DR   EMBL; AYLP01000133; ESS63311.1; -; Genomic_DNA.
DR   EnsemblProtists; ESS63311; ESS63311; TCDM_08916.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017861};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    378    403       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    415    438       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    504    525       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    537    561       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    600    624       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    711    731       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       95    136       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   773 AA;  87968 MW;  F50FF0A005B111BE CRC64;
     MPREAASGLW RSEDMTMLQL TMQRETAHDS VLKLGQLAAF QFIDLNGDVN AFQRDFVQEV
     RRCDDMERKM RYLHEEIEKA GVKSVPGQVG ERETMFSLEQ KVDEREAEVR ELNEQYQSLI
     EERNRSREHL EVLNRDFSAS STHSQGLNLI TGVIPKERVP ILERLVYRAT RGNSVMQTDD
     IATPFYNVAT NQPIYKCVFG IYFPVPRLRE SLGKISEANG ATIYAYAENE EQLQGMRESL
     QVQVETVTHT LQQSALRQRQ LLMGISASVY EWRRAVAVEK AVYSTMNMLR FSGATVVAKG
     WAPVRSLDDI RTALQEAEYL SGAQVLTIVE GVTTKETPPT YFRTNKITSS FQGIVDSYGM
     ARYKEVNPGV FTIITFPYLF GVMYGDIGHG LILTIFSAFL IFMEKSWEGK PLNEIFAMIF
     GGRYLLLFMG FFAVYLGFLY NDMFGFSVEV FTSGYRWPQL PPNGPDGVVR PSLPVGVTPA
     HSVIFGVDSA WAETENKLEF YNSIKMKCSV IIGVVQMMVG VILSLMNHLY FGDKLQVWFR
     FVPEIVFLSC TFGYMCLLIV IKWCTPWENR THDAPSLLET MTNFFLQPGT VNLPLYRGQA
     VIQVLLLLIA FAMVPILLFV IPFMEKKHHD KAMKRKALLH EEDEEEKDEF DFSEVMIHQV
     IHTIEYVLGC VSNTASYLRL WALSLAHSQL SEVFWNFAFL MTVGLDGGSG IFVFVGFCVW
     MCATLGVLLG MESLSAFLHA LRLHWVEFNN KFYSADGYAF TPFDVAEVLS KIN
//
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