ID V5DAB4_TRYCR Unreviewed; 488 AA.
AC V5DAB4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=DNA ligase {ECO:0000313|EMBL:ESS64406.1};
GN ORFNames=TCDM_07546 {ECO:0000313|EMBL:ESS64406.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64406.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS64406.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS64406.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS64406.1}.
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DR EMBL; AYLP01000091; ESS64406.1; -; Genomic_DNA.
DR AlphaFoldDB; V5DAB4; -.
DR EnsemblProtists; ESS64406; ESS64406; TCDM_07546.
DR VEuPathDB; TriTrypDB:TCDM_07546; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR029319; DNA_ligase_OB.
DR InterPro; IPR025487; DUF4379.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR47810; DNA LIGASE; 1.
DR PANTHER; PTHR47810:SF1; DNA LIGASE B; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF14743; DNA_ligase_OB_2; 1.
DR Pfam; PF14311; DUF4379; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Ligase {ECO:0000313|EMBL:ESS64406.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..488
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004731966"
FT DOMAIN 263..427
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 488 AA; 54680 MW; DDF7A013C98EA7EC CRC64;
MKACQLRLSF LFALSALRMG RVSRTRLPIT PPANLATFHP AIASSWMTAA SNKLLQPQHV
LPTSRKLAWW RCPHCGHEHH KRIDLHVAAG GVCPRCQRMP TLLHPSDASS AVLTIPLVKH
RCRPDNSLSV LAAANANRVK SSIADDGYLR VVETRNLQPM LARNFEKESD TIDDDAVLFV
SPKLDGVRCI VAWNVRERRP CFFSRSGTLF ECCDHRIEPR LRPLFEKDPN LVLDGELYNH
NVDDFEQLIS AIRTTRDRRT PAIAKLQEQL QYHAFDIMYA SKFPDMSVVP FSERHKHLGR
LIHGLASSKG QVQEKAVVLV PAAQVKKADI PRLLRLSLAD GYEGIIVRRD GVVSARGENN
CSRSGTSRGV NKSSSRGLVV GYAYGARSPN LLKYKVMQDD EYVIVSGVEG RGKWKGCLGA
FVCRTKRGHQ FTVAPATTEQ RKKDMWQRLA QYKGKMLTVQ YQELSANGVP RFPIGKCVRG
AKSGKDWI
//
