ID   V5DBY4_TRYCR            Unreviewed;       445 AA.
AC   V5DBY4;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Thiol-dependent reductase 1 {ECO:0000313|EMBL:ESS64956.1};
GN   ORFNames=TCDM_06784 {ECO:0000313|EMBL:ESS64956.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64956.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS64956.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS64956.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS64956.1}.
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DR   EMBL; AYLP01000075; ESS64956.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5DBY4; -.
DR   EnsemblProtists; ESS64956; ESS64956; TCDM_06784.
DR   VEuPathDB; TriTrypDB:TCDM_06784; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   CDD; cd00299; GST_C_family; 2.
DR   CDD; cd00570; GST_N_family; 1.
DR   Gene3D; 1.20.1050.10; -; 2.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR041695; GST_C_5.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR43968; -; 1.
DR   PANTHER; PTHR43968:SF6; GLUTATHIONE S-TRANSFERASE OMEGA; 1.
DR   Pfam; PF16865; GST_C_5; 2.
DR   Pfam; PF13409; GST_N_2; 1.
DR   Pfam; PF13417; GST_N_3; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SFLD; SFLDG00358; Main_(cytGST); 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 2.
DR   SUPFAM; SSF52833; Thioredoxin-like; 2.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
DR   PROSITE; PS50405; GST_CTER; 2.
DR   PROSITE; PS50404; GST_NTER; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT   DOMAIN          2..82
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          88..218
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
FT   DOMAIN          226..305
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          312..440
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   445 AA;  50684 MW;  08780E2317DE406B CRC64;
     MKALKLFKDR MCPYCQRVLI TAKEKRVKLE EVEVPLGDDM PQWYKELNPR ETVPTLQVDG
     KKCMIESDLI SRYIDRISSP ANALIGSSPY QRHRVEFFLS EIGDLIKAYF GLLRDPFNEE
     KRKSVDHNTA YIEGIIAEHQ GDGPYFLDDT FSMAEVMVVP FLACFRPVLS YYCGYDIFHE
     APRLKKMYVT SMQRTTVKET VLKPEEYIIG FKRKVPTSHV TWSLAPGYVL FVNKYSPFSD
     RPRLACALKN IDLPMLEIDL KQLPSWFRWF NQRETVPALL TPQGTHVHES QLIVHYLDDG
     FPEHGPALLP KDADGLYHVS FVESNVDYFM DAMFSLIKDP KNMNAKEEFD WAAGELEKLL
     AEHQFGEGPF FGGASMNAAD VSLVSMLVHL KACTPDLTEG QDLLANYKLL TAAAEAGLTS
     EAGKKVFFSL SEYSSIYKTF LRPSS
//