ID V5EU37_KALBG Unreviewed; 2182 AA.
AC V5EU37;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Acetyl CoA carboxylase {ECO:0000313|EMBL:EST08865.1};
GN ORFNames=PSEUBRA_SCAF14g01620 {ECO:0000313|EMBL:EST08865.1};
OS Kalmanozyma brasiliensis (strain GHG001) (Yeast) (Pseudozyma brasiliensis).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Kalmanozyma.
OX NCBI_TaxID=1365824 {ECO:0000313|EMBL:EST08865.1, ECO:0000313|Proteomes:UP000019377};
RN [1] {ECO:0000313|Proteomes:UP000019377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GHG001 {ECO:0000313|Proteomes:UP000019377};
RX PubMed=24356824; DOI=10.1128/genomea.00920-13;
RA Oliveira J.V.D.C., dos Santos R.A.C., Borges T.A., Riano-Pachon D.M.,
RA Goldman G.H.;
RT "Draft genome sequence of Pseudozyma brasiliensis sp. nov. strain GHG001, a
RT high producer of endo-1,4-xylanase isolated from an insect pest of
RT sugarcane.";
RL Genome Announc. 1:E0092013-E0092013(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001455};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR EMBL; KI545856; EST08865.1; -; Genomic_DNA.
DR RefSeq; XP_016293854.1; XM_016434806.1.
DR STRING; 1365824.V5EU37; -.
DR GeneID; 27417413; -.
DR eggNOG; KOG0368; Eukaryota.
DR HOGENOM; CLU_000395_5_2_1; -.
DR OMA; DFEDNTI; -.
DR OrthoDB; 911at2759; -.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000019377; Unassembled WGS sequence.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF3; ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000019377}.
FT DOMAIN 38..546
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 195..387
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 673..747
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1455..1791
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 1795..2110
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 2182 AA; 239580 MW; 93AB30DFA1BC8048 CRC64;
MPPPDHKAVS HFIGGNPLET APAGAVTDFI RKQGGHSVIT KVLICNNGIA AVKEIRSIRK
WAYETFGNER AIEFVVMATP EDLKVNADYI RMADQYVEVP GGSNNNNYAN VDLIVDVAER
AGVHAVWAGW GHASENPRLP ESLAASKHKI IFIGPPGSAM RSLGDKISST IVAQHADVPC
MPWSGTGIKE TIMSEQGFLT VSDDVYQKAC IHTAEEGLEK AEKIGYPVMI KASEGGGGKG
IRKCTNGEDF KQLYNAVLGE VPGSPVFVMK LAGQARHLEV QLLADQYGNA ISIFGRDCSV
QRRHQKIIEE APVTIAPEDA RESMEKAAVR LAKLVGYVSA GTVEWLYSPD SGEFAFLELN
PRLQVEHPTT EMVSGVNIPA AQLQVAMGIP LYSIRDIRTL YGMDPRGNEV IDFDFASPES
FKTQRKPQPQ GHVVACRITA ENPDTGFKPG MGALTELNFR SSTSTWGYFS VGTSGALHEY
ADSQFGHIFA YGADRSEARK QMVISLKELS IRGDFRTTVE YLIKLLETDA FESNKITTGW
LDGLIQDRLT AERPPADLAV ICGAAVKAHL LARECEDEYK RILNKGQVPP RDTIKTVFSI
DFIYENVKYN FTATRSSVSG WVLYLNGGRT LVQLRPLTDG GLLIGLTGKS HPVYWREEVG
MTRLMVDSKT CLIEQENDPT QIRSPSPGKL VRFLVESGDH VKAGQAIAEI EVMKMYLPLV
AAEDGVVSFV KTAGVALSPG DIIGILSLDD PSRVQHAKPF AGQLPDFGLP IIIGSKPHQR
YSYLVEVIND ILDGYDQSFR MQAVIKELME TLRNPELPYG QASQILSSLG GRIPARLEDV
VRNTIEMGHS KNVEFPAARL RKLTENFLRD SVDPAIRGQV QITIAPLYQL FEAYAGGLKA
HEGNVLASFL QKYYDIESKF TGEADVVLEL RLQADGDLDK VVALQTSRNG LNRKNALLLT
LLDKHIKGTS LVSRTSGAQM IEALRKLASL QGKSTAPVAL KAREVSLDAD MPSLADRSAQ
MQAILRGSVT SSKYGGDDEY HAPSLEVLRE LSDSQYSVYD VLHSFFGHRE HHVAFAALCT
YVVRAYRAYE IVNFDYAIED FDVEERAVLT WQFQLPRSAS SLKERERQVS ISDLSMMNST
RKTVAPAELR TGAMTSCVDV SDIPDLLPKV LKFFKSSGGS PINVLNVAVV DQADFVDAEV
RSKLAQYTNA CSKQFAAARI RRVTYLLCQP GMYPFFATFR PSEHGIWTEE KAIRNIEPAL
AYQLELDRVS KNFELTPVPV SSSTIHLYFA RGIQNSADTR FFVRSLVRPG RVQGDMAAYL
VSESDRIVND ILNVIEVALG QPEYRTADAS HIFMSFIYQL DVSLEDVQKA IAGFLERHGT
RFFRLRITGA EIRMILSGPN GEARPIRAFV HNETGLVVRY ETYEENAADD GSVVLRAIEP
QGKEASLNGQ SAHFPYTTKV ALQSRRSRAH ALQTTFVYDF IDVLGQAVRA SWRKVAASKT
PSEVIKSAVE LVFDEQENLR ELKRAPGMNN IGMVAWLVEV ATPEFPAGRK LVVVGNDVTI
QAGSFGPVED RFFAAASKLA RELGVPRLYI SANSGARIGL ATEALDLFKV KFVGDDPAKG
FEYLYLDDDS LHVLQTKAPN SVMTKPLKAA DGSNHNVITD VIGKPQEGLG VECLSGSGLI
AGETSRAKDQ IFTATIVTGR SVGIGAYLAR LGERVIQVEG SPLILTGYQA LNKLLGREVY
TSNLQLGGPQ IMYKNGVSHL TAQDDLDAVK AFVNWMSYVP AQRGGPLPIM PTTDTWDRAV
TYQPPRGPYD PRWLINGTRD ESGAKLTGLF DDGSFVETLG GWATSVVTGR ARLGGIPVGV
IAVETRTLER VVPADPANPS STEQRIMEAG QVWYPNSAYK TAQAIWDFDK EGLPLVILAN
WRGFSGGQQD MYDEILKQGS KIVDGLSAYK QPVFVHIPPM GELRGGSWVV VDSAINDNGM
IEMSADVNSA RGGVLEASGL VEIKYRADKQ RATMQRLDSV YAKLSKEAAE ATDFTAQTAA
RKALAEREKQ LSPIFTAIAT EYADAHDRAG RMLATGVLRS ALPWENARRY FYWRLRRRLT
EVAAERTISE ANPLLKHVER VAALRQFTGA AASDDDKAVA EHMEASAAQL LAATKQLKAQ
YILAQISTLD PELRAQLAAS LK
//