ID   V5G4Q2_BYSSN            Unreviewed;       572 AA.
AC   V5G4Q2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Short-chain dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PVAR5_8118 {ECO:0000313|EMBL:GAD99403.1};
OS   Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces
OS   variotii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX   NCBI_TaxID=1356009 {ECO:0000313|EMBL:GAD99403.1, ECO:0000313|Proteomes:UP000018001};
RN   [1] {ECO:0000313|Proteomes:UP000018001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=No. 5 / NBRC 109023 {ECO:0000313|Proteomes:UP000018001};
RX   PubMed=24407650; DOI=10.1128/genomeA.01162-13;
RA   Oka T., Ekino K., Fukuda K., Nomura Y.;
RT   "Draft genome sequence of the formaldehyde-resistant fungus Byssochlamys
RT   spectabilis No. 5 (anamorph Paecilomyces variotii No. 5) (NBRC109023).";
RL   Genome Announc. 2:E0116213-E0116213(2014).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD99403.1}.
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DR   EMBL; BAUL01000295; GAD99403.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5G4Q2; -.
DR   eggNOG; KOG0725; Eukaryota.
DR   HOGENOM; CLU_476475_0_0_1; -.
DR   InParanoid; V5G4Q2; -.
DR   OrthoDB; 662155at2759; -.
DR   Proteomes; UP000018001; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR43008; BENZIL REDUCTASE; 1.
DR   PANTHER; PTHR43008:SF1; NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF13561; adh_short_C2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018001};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..572
FT                   /note="Short-chain dehydrogenase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004733120"
FT   REGION          59..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..119
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..262
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   572 AA;  59449 MW;  72BB9FEB0BA13399 CRC64;
     MVKAGAVALL AIASPAFAGV VKARGGDYIV PVPLSTGVIP PPPPPPPAWS WVSVTPCDTP
     TPTPTPETTP CETPTPTPEV TTPCETPTPT PETTPCETPT PTPEVTTPCE TPTPSPWKPW
     PNQTTDYITK TTTFVTTTCP VTSSVVTSGT QTLTVPVTLT NTITQTQTTV VPTVVPVPVP
     VPGKNETYTT KTTAYVATSY PVTSSVVISG NQTKTVPITQ TSTYTHTGVT VVPAVPTGAA
     PAPGAPAPSP GAPAPAPEQP SYVAPAPSAE KPTSAQPTPV SPSSPPAFTG AASRLDKPVA
     GFIAAAVGAM ALLSSTAAKM SMTLSECAQA RGGFPRPYPD TPTNVLEQFK MTGKVIVVTG
     AADGIGYAVA EAIAEANGAV ALWYNSNDVA IQKAEALAKT HGVKAAAYKV NVSDPEEVQK
     TISDVLKDFG RIDVFIANAV DGVVYCAKYA GEVFKRQGTG NFIITSSMSA HIVNVPVDQP
     VYNASKAFVT HFGKSLAREW REFARVNIVS PGFFETKMGA SPRVINEAYR MSSLGRQGHV
     KEIKGLYLYL ASDASTYTTG SDMIIDGGYV LP
//