ID V5G9U2_ANOGL Unreviewed; 113 AA.
AC V5G9U2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE Flags: Fragment;
GN Name=UCHL5 {ECO:0000313|EMBL:JAB60779.1};
OS Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Chrysomeloidea; Cerambycidae; Lamiinae; Lamiini; Anoplophora.
OX NCBI_TaxID=217634 {ECO:0000313|EMBL:JAB60779.1};
RN [1] {ECO:0000313|EMBL:JAB60779.1}
RP NUCLEOTIDE SEQUENCE.
RA Scully E.D., Hoover K., Carlson J.E., Tien M., Geib S.M.;
RT "Midgut Transcriptome Profiling of Anoplphora glabripennis, a
RT Lignocellulose Degrading, Wood-Boring Cerambycid.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C12 family.
CC {ECO:0000256|ARBA:ARBA00009326}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GALX01007687; JAB60779.1; -; Transcribed_RNA.
DR AlphaFoldDB; V5G9U2; -.
DR EnsemblMetazoa; XM_018712308.2; XP_018567824.1; LOC108908294.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.40.532.10; Peptidase C12, ubiquitin carboxyl-terminal hydrolase; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001578; Peptidase_C12_UCH.
DR InterPro; IPR036959; Peptidase_C12_UCH_sf.
DR PANTHER; PTHR10589; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR10589:SF16; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5; 1.
DR Pfam; PF01088; Peptidase_C12; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:JAB60779.1};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 8..112
FT /note="Ubiquitin carboxyl-terminal hydrolase family 1
FT cysteine active-site"
FT /evidence="ECO:0000259|Pfam:PF01088"
FT NON_TER 113
FT /evidence="ECO:0000313|EMBL:JAB60779.1"
SQ SEQUENCE 113 AA; 12782 MW; C3BFE77625AC8DE9 CRC64;
MAESAGNWCL IESDPGVFTE LIREFGCKGV QVEELWSLDG EQFENLKPIH GLIFLFKWTK
EDDPSGSLVQ DSRLEKIFFA RQVIENACAT QAILSILLNC RHTDLKLGHT LTE
//
