ID V5GER5_IXORI Unreviewed; 323 AA.
AC V5GER5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Putative acetylcholine receptor {ECO:0000313|EMBL:JAB68660.1};
DE Flags: Fragment;
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB68660.1};
RN [1] {ECO:0000313|EMBL:JAB68660.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB68660.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; GANP01015808; JAB68660.1; -; mRNA.
DR AlphaFoldDB; V5GER5; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18989; LGIC_ECD_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF865; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:JAB68660.1};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 22..323
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022261956"
FT DOMAIN 38..193
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT NON_TER 323
FT /evidence="ECO:0000313|EMBL:JAB68660.1"
SQ SEQUENCE 323 AA; 36619 MW; 021005C20DDE71FE CRC64;
MRVRWIPLLV LIGWQHGLAT CDETPSDEYL SHRQLLRAKL FDPSKYDVNQ RPNNGSSSPT
NVSLHPLLGN TTTFMNLEDG WLSLSMVTCN NWYDTALEWD PDDYGGLESI STFPSEIWYP
DIEIVNTSPD DYTTQPITVY LEHDGEIWFC QPVTAKIPCS MDLTDYPFDS QVCRIRFALL
AYGDEEVRLG GEGIMSHSVT NQSSEWQVTF LDTSHGTLLN KTSLDMAIGM KRRGTHHRCT
TTLPWVASVI LVLLGFWMPA NSNRRLTLAC INLLLIMLMP QRITPLLETS TAVPKIALFL
GNAMVDPKYV RRTVRRTVTT TRV
//