ID V5H0Y2_IXORI Unreviewed; 981 AA.
AC V5H0Y2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Putative epithelial chloride channel protein {ECO:0000313|EMBL:JAB70559.1};
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB70559.1};
RN [1] {ECO:0000313|EMBL:JAB70559.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB70559.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
CC -!- SIMILARITY: Belongs to the CLCR family.
CC {ECO:0000256|ARBA:ARBA00006398}.
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DR EMBL; GANP01013909; JAB70559.1; -; mRNA.
DR AlphaFoldDB; V5H0Y2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013642; CLCA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR NCBIfam; NF041940; choice_anch_X; 1.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF08434; CLCA; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..981
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004737625"
FT TRANSMEM 937..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 313..484
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 715..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 107327 MW; CEB41D08ACCDA377 CRC64;
MKAATLSLPL VAALCFPLIC GVRIDTSDGG YRDVVVAIHP SVAPDENIIV NIKALFREAS
LFLHRATRGR VFFKDVTIAV PSTWPRREKA LTTGSSLFDG ADLRVAGPNP EYGDTPYTLQ
PRGCGEVGEY IHITPAFLSG LNGTTSKKYG SPAFQLVHEW AHYRYGVFDE YGTPGDYRYP
SLYCEFGMVR ANACSVRMRF TASTKDGEPC RVYRGCKVST KCNAKFYQNT RDPVESSVMF
MPYIPGVSQF CDDSSRKHNI FAPSKHNHIC QRRSTWDVIS NNPDFQNLGD PLPETQVQVK
FQEVQQRNDS LGKGVMALDI SGSMNDYNRL VRLKSAATHF VRDVLPNDFL LGIVVFSYTA
TVTQRLTAVN NTSRTDMAKA INRLAANGKT CIGCALKQSI QVLKEGGKTA EGDTIILMTD
GEENKDPRIA AVLPELLTEK VVVNTVALGT SAAKELENLA LMTGGKAFSL SDSQANIEAA
MESAFVESTT AQLDEADRPI TILDESIKLK KSQEIPIMID PELGKDTKVV IMSGNPNDLV
AHVSDPRGNT CENCSFRISN SGSKWLTVEI PSPAMPGTWN LALLTRASRD VVNVRVTSMA
VAADDHPIRL RTFLKKLDVN HALDACIYSE VSKGPHAVLR AKVLAKVMTP QQNVGQLIVE
LFDDGVGADV TANDGIYSAY FTQFKGNGRY SVVAEVVGDG SAIVVRGRRG SGGLPVVASA
PEQSTNWPPT EKTASASPEF GAEGLPFEQF IYVDEDIEVA EPQEIRGKKA PNFRRFSDGG
SFRVDGAIEV SKIPPASIQD LRVADVITEN GTLCVVLSWT CPGEHLDYGQ ASQVEIRVST
NMASFLKRFE DGVLIPESDV VEGQLSPLPA RTKQNVTIKI PEDVVSEAKI ENRTDFYFSA
RVLNKDGLDS GASNIALATF EHPSPRQQQN PPDLKNWVLL IGVPVAVILL VIVILAVVFG
RRRTSRQQIR PATKLRRIHY V
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