ID V5H5I0_IXORI Unreviewed; 461 AA.
AC V5H5I0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=alpha-L-fucosidase {ECO:0000256|ARBA:ARBA00012662};
DE EC=3.2.1.51 {ECO:0000256|ARBA:ARBA00012662};
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB69537.1};
RN [1] {ECO:0000313|EMBL:JAB69537.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB69537.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
CC -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC carbohydrate moieties of glycoproteins.
CC {ECO:0000256|ARBA:ARBA00004071}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 29 family.
CC {ECO:0000256|ARBA:ARBA00007951, ECO:0000256|PIRNR:PIRNR001092}.
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DR EMBL; GANP01014931; JAB69537.1; -; mRNA.
DR AlphaFoldDB; V5H5I0; -.
DR GO; GO:0004560; F:alpha-L-fucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006004; P:fucose metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR016286; FUC_metazoa-typ.
DR InterPro; IPR031919; Fucosidase_C.
DR InterPro; IPR000933; Glyco_hydro_29.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10030; ALPHA-L-FUCOSIDASE; 1.
DR PANTHER; PTHR10030:SF46; ALPHA-L-FUCOSIDASE-RELATED; 1.
DR Pfam; PF01120; Alpha_L_fucos; 1.
DR Pfam; PF16757; Fucosidase_C; 1.
DR PIRSF; PIRSF001092; Alpha-L-fucosidase; 1.
DR PRINTS; PR00741; GLHYDRLASE29.
DR SMART; SM00812; Alpha_L_fucos; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 2: Evidence at transcript level;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001092};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001092};
KW Signal {ECO:0000256|PIRNR:PIRNR001092}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|PIRNR:PIRNR001092"
FT CHAIN 20..461
FT /note="alpha-L-fucosidase"
FT /evidence="ECO:0000256|PIRNR:PIRNR001092"
FT /id="PRO_5016196528"
FT DOMAIN 364..458
FT /note="Alpha-L-fucosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16757"
SQ SEQUENCE 461 AA; 53454 MW; 79FBC385BE3B9207 CRC64;
MMQGSLLLLF LASLGSTSSR RYTPDWKSLD TRPSPSWFDE AKVGIFLHWG VFSVPSFKSE
WFWSEWSNKD PEVVEFMRQN YKPNFTYPEF APQFTAQFFD PDRWADLFYK SGARYVVLTS
KHHEGYTLWP SSVSWNWNAG DVGPKRDLVG DLATAIRKKG GGVHFGLYHS LYEWFNPLYL
ADKAARWTTN DFVVRKTMPE LREIVERYKP DVIWSDGDWE ANDTYWNSTE FLAWLYNDSP
VKSSVVVNDR WGIGIPCHHG DFYNCHDRYN PGILLKHKWE NAMTIDKHSW GYRRNANLSD
YLSIEKLIEE LASTVSCNGN ILINIGPTKD GIIEPVFEER LLQLGRWLGV NGEAVYGSKP
WKHQNDTLTP GIWYTTNKDM DVVYVFVLRW PRFNKLTLES LVLSQRARIT MLGLNDDLFQ
WDRTGGSDDS SRRTVTILFP PLTPDLLPTP WAWVLKVEGA L
//
