ID V5HBS2_IXORI Unreviewed; 575 AA.
AC V5HBS2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Putative conserved plasma membrane protein {ECO:0000313|EMBL:JAB74769.1};
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB74769.1};
RN [1] {ECO:0000313|EMBL:JAB74769.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB74769.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; GANP01009699; JAB74769.1; -; mRNA.
DR AlphaFoldDB; V5HBS2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IEA:InterPro.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR PANTHER; PTHR21522:SF61; PROTON CHANNEL OTOPLC; 1.
DR Pfam; PF03189; Otopetrin; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 575 AA; 65905 MW; 96C76F9A14F48882 CRC64;
MYGTRRAHGD LDSLVIMLSA LYAKLLVIMG ICFPLGEVIS KKIPVSFYEG FYLYLYFGSI
AFLLYVYVFL LKHEKVNSKL EQFTESFGDK MRRLVGMRCA KNTNMEIPPI QKRRVYDATT
HAGSFYLRLG AVAFGTGSMI YSGLEFGQFF EMESDSKCYN ILFSLTPATR MAFTFFQLYF
IFINSRVAIS KFTTFARFGL MHMISANICV WLHVLIQETK HQILELINRN ETQIMAFAVN
QASLVPEDEE DHLNPVHYET HSKDHHRMER SADHGIHHES HNCRRANIMG ELVQNASPFL
FPCTIEYSLI CAGILYIMWK NVGSSHPMPA TPDSSVQVHT PRQRHYYQVD CAKANKGLFT
GILVLVLSII SLILFFVLIN KPQYRKLAVM EAHIAELAVY VLASLATMTA LFQVRELRYN
RLRNTDLDSI LLIVAQSGLY LYTMFSIIGG HFTLDQNTML ALLTALACLI QGSLQTIFIL
DASRRYVSSS DQANRKPGRE MVTFLIVCNF SMWAINTLET RRADSNPVQM NFYGFWAWTI
ITHVTAPLTI FFRFHSTVCL CDIWKRAYKV KSDYL
//
