ID V5HG79_IXORI Unreviewed; 5622 AA.
AC V5HG79;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Putative short stop {ECO:0000313|EMBL:JAB76534.1};
DE Flags: Fragment;
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB76534.1};
RN [1] {ECO:0000313|EMBL:JAB76534.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB76534.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
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DR EMBL; GANP01007934; JAB76534.1; -; mRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 14.
DR Gene3D; 1.20.58.60; -; 25.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 4.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00681; Plectin; 2.
DR Pfam; PF00435; Spectrin; 20.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 12.
DR SMART; SM00150; SPEC; 30.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 5.
DR SUPFAM; SSF46966; Spectrin repeat; 25.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5435..5470
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5471..5506
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5518..5590
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 1..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2616..2705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5303..5380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2478..2538
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2736..2817
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3283..3350
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3399..3493
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3864..3898
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3975..4002
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4666..4714
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1535..1556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1594..1609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1661..1711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2634..2672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2687..2705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5320..5335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5341..5355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAB76534.1"
SQ SEQUENCE 5622 AA; 634587 MW; 50AE4BF73A2165DD CRC64;
QEKLPSVKGL PLERGKSPVK EAAPSHTKDR PRDLPGRTSP SKEIGKAREH SPTKAFPEEK
VPSARDQPGG RASPTKEHPS RGDQSPARDV PKEKSASRLP KDESDREPSP TRDGTRRTPS
PSKGLPTDRP PSDIEKLPKE TTGGIQRDKE PVRESPVKRE PSPSKEVPQR ISSPTKEHEI
KKPSDEKTSK AGSPSGTRPN VRTPSPSKET TKQKVPPSAK DKAPSPTKEF DKGHRPDTDQ
RSPERGSPPR FEETKVSTIV YIPQMTDSQG RAPSPEKGSP KKGREEPDGK PKSPTRPKAR
APSPPRRVSP DTETVTETGR TITTRVIERG GTTITKFTRE TQVLEIPPDG WYLKEAIEQK
LFDAKEGLFL IPGTDRLVSL EETLKMQIVN PDSATVHEPG SKRTLSLIRA LEKNILDSTG
HYHDTKNKET LTMEEAIRRK VIILLERVDY WTPEQARPRS IHVTKVSGQP DVIEVKEGPE
AMLEEIPKQD FPKFSEIASE VTFDNESLTV VDKGSGTTMD LVSALQTGLV DDNEFVVRDE
ETKKEMRYSE AVEKGIIDKG TGTYKDKKTG RTFKLGEAVK LGLLAIAASP MIVGFKAAEA
VRGLRSARDE VTHATAVGTE PIRATKETTK IIRTATLHIR DAETGREVPL EEAVSLGLID
AETAKQLEDQ SKTTEQTVHT TTTVMVTDPV TGENITLDEA LQKGLLDKEA VEKLEKGDVT
GVVTTLETCL QDPDKGTTLA YQEFMTKPKG EVSEQAREEK KRRVSPTRPL QASYAEPKFE
VTLGRATTLQ SPEREVVILQ KVRRRALTPK DAEKEGIIDK AAMDILKDVD SLKDSKGRRV
GLDEAIKLKL VDGTKGGVLE PRQGDRVSIT EAVSQGLLDT NTGRVLVPIG RCLSLPELVS
QGVVNPDTQR IVHPETGSCL TLQEAILCDI VNPLSRVPGL TKKSTLTLEE AVASGVIDEE
SGMLKTPSGS MTLVDAVQKH KVFEQPKASR SDKLIPMLAL TFPVALQHGF IDTKAKTFTH
PVTKKKIPIQ QAIKDGLLLP IPSNPDPDSV HVCEALDCNL VDERRQTLKH PRTGEEIPVM
DAMDSGLLQL SPFDKSRVVP QTRVDTQFQD TTRTMVTSHY TTLTRQTTVI LKPGYVMLGP
NQVKNVDTGE VISFERAKEL GVAEVETSEG SERPTFSDAV RRGLVDFQRG VYTDVVRGMT
MPISEAILEG LLEQDRVEPA QPGKYTIIQV FELYYDEVIF LFRVPNVDQP LTFEQLLERG
YLDLNAVIYD MSEGVIMTTE EAIESGHIDT KTGKLRREGQ EPVSIKDAIR AGLLVAIEAP
LLATLKGTER LRRIPPARSP VDKPQEATKR RSPSPPKVTS PKKGSPREQS PTKETPTRET
LPKATQEAPT KGAPAKTSPS KELPAETGKD FRPSSPTKTP RGESPRKEDK PIPGKKAPDE
TPRTPKDVQS PVKTSPSKEP SPDAGEYFRP GSPGKTPRGI SPSKEDQLAP GKKAPDETPG
TSEGRQPPVK TSPSKEFPVD TGKDVGPGSP GKIPRSESPK KEDKPVPGKK APGETPRASE
DGQPAKAKAP VERSPSREVK EPGPPTRPPR TTPSPGKDTR EKSPTKEAPT KAPTKEVPSR
VPKSPTKEAP VKPTEKVLTK EVPTRPTDKA PTKDVPLKSS KETPTRGSPS KSPTKDVPSR
GAPTSTPTRP GRASTSPGKE TTPSTSRQTV QTAVKTNVFE SPEQQQVAPF SSVSEHEVKL
TTTGEWVPTK EMSSFSSTEV VVKQTFTEFR RDYEAEIVVG DQLSVRNLLR GDVLAPKNFT
VFIPSSGRTM RLEDALETRQ VTEDSIIMVR SMNELVLMDI GRIVPDFTLD YAVREGFYNP
DKKSFTNPKT GKPISFSDFV AQKFVDLSDV KVKDYKAKEM VDLKTALSRN IVDRETGQMT
HPETRQRISF FDAFVLCWIV RESVVHSRSE SLTLSQAIRG LGYDEEKSAM QEKYKSCDES
ITNLVSWIGE IEMRLANLGN VYEDVDGLRH QIGTAKTIKE ELDLNQNLVS SCTDQVRQIS
QQGHDLLSKE ELETLQKEVN KFKGRYDHCQ DMGERLLRRL TTALEELQKY TSEMQVFKDW
LSNAHKILTR HEELLSDIRN IADNADHYRT FSSDVIAHQA DLRFITMAAQ RFVDESKDYL
RSLNDFRTNL PRRLGHVEPT ESEVKSQVGQ VTTDYQNLLN RVNRLGDRFS GLGDRKRNYH
DSVERATTWL NEAQRNAKRL LEEPTAAEPK AIQDQLDRVR AFNLEAVGQG RLIETAKHAA
QSLLSSLEGA SAAERKQIEE TVKNLEEVYQ QMLGLIGDKS NELQTALVHS QDIQDGLDRV
LRWLDDVESS LRNQSKPASL IRERLDEQIH EHRVLQSEID SHRPAIDAIN SSARELLSSS
NARLAKKVES KLKDVNSRFE KLHEKSVRRG ELLDEVSSCL DMFLTMTGRF DEWFASVLQS
VEGPEATRAS SEEQITRLEH AMNQRNSHKD EFEDLLRAGK ALCAKRDVTD TTHIRDKLKQ
LEQQWKELGD LLAEQQRQGR ARSEQHSAYE SLRLKVLDWL NHMEVRVDGL DAVAVDREVL
RRQASEIKPL VKEHADYAST IDRVNDLGRT YDALLHHGES PRRGPASRGP ASSPTKKIPA
SPTRGVKGTP SSTTSSSEYY ANGTTTGAAA EVQGSPDSAG GKAAPSVLQS PLSSASSGFS
SRHSSVDQFG GLDDLSPVQQ QLSEINHRYH LIGVKLSDRQ QEMESLAEEL KRFQDNLKAL
LAFVQTKERS LPKESLPATK ELAEKQLTVL KELQSDLQEK QIEVDRLRVQ VQELLRRKPN
APGSESLQQQ LTELLSRWQE LLQAIRIRLL LIQEFKDFQD THDLLHNWLS QKDKMFQVLG
PIAHEPRMVA AQTQQVLVMR DEFSSQEPLL RRMNLCGQEV VGQLEPNNPA GRKIRDQMDA
IKRHWNEMIG RLEERERSLG AATGATTDFH TVLGKLLEAL QNIGDDFDQL AEAGDLEEQL
RRLRGLDDRL EAQRPPLAES EAMCDHLCDI LTDAASRNEI KGKWGTADKL YNNLNRKINN
RKAELESSLR EDRGFFSTCE DIQGWLQEIQ HTLSPDFKIS ADTDILHRQV TEFEPAYKSL
LDKEHEVHLL LSKGTDMVAK MTRKQESQQL RTRLDAMRKA WDKIRKEATD RHTRLQRAFE
NCKKFNAAFN KFGPWLQTTE ARFYDLGPIS YHRPETEKQA KELQGFKNEI SRHSQEYDSV
RNLGETFLSG CDVDKEGVKK DLDTLRTRWE KLNQGVTDRS RELDEVSAKL AEFQDKAREL
NHSLQRMEDK VASHDALGDA ARNPQLLERM KALLREAEEL QRGLDRLRAF AEGLVASASP
DSDTTHIRKE VDDLTRRHQQ LTSKLEDRCA QLESASSVVA QYNNKVKTAH QDLTSLEEEL
ENMGAIGRDI RTVNGQIEEV KNFKVKLSTT EDEIQDAERE CKDLINHGYT QDAKGARTQL
DTLKRQLNRL QERTKGRSLA LDQMLAKLEK FYQDLGDIQR SLSEATNEER AFRPVAADVD
TIRTQQEEFK HFRKSCVEPL GKEIDEISRV GNGLIQSASP GVNTAILERD VDKLNDEWNL
LKEKMSERER KLDVALLQSG KFQEALAGVE KWLQDTEEMV ANQKPPSSDY KVVKAQLQEQ
KFLNKLLLDR QSSMTSLMTM GNEVMRNLAP SEKAHIQSQL QDLSQRFDRL NRGAQERMSA
LERTLPVAKA FQEKMCPLVE WLEQTERRLG TMGTIPTDQD RIAHRVQDHR DLHRDILGHK
HSFEELTEIA QTLMGLVGDD EAQAVVESMQ EVTDRYARLV EDSERLQQLL AEARAGANAF
VVNFEDLLVW IGEMESRLSR YQVLSVYVEK LQEQFEELSE LSDEIADHQK QVDDLTGSGQ
DLMRHASGDD AIQLKERLDA LHVRYTDLTQ RASERLRQAQ EALPVARNFH SSHERVVVWI
DDAEAALKSV ESSALTSQEC TIQRLEQEIQ EVRSVLEVVN HLGPQLCQMS PGEGAVVVES
MVSRVNRRFD AVCEQIQRRA ERIELSKQRS VEVVGDIDDL LDWFRDVERQ LANAEPIIPE
PEALAAMLKE QKALNEEVSS QKGRVRDILA SAKKLARESP PEDQALIRDK AEDLKALVAS
VTAACADRLS ALEQALPLAE HFLETHLDLV QWLDEAESEA ERLGAPSLHA GQIKRQQDRN
NALLQAVTER KPLLDKLTKT GAALIKLCSP SEGKKVQYLI NSDSERYNAL RNLLREQQNL
LEEAMQSTSQ FADKLDGMLN ALASTADQLN NAEPISAHPE KIQEQISDNQ AVVTDLGKKS
PALEAVKKAA REVIAKAGGD QEPTVRDLKR KLERLNDLWE GIQKAARTRG QSLETALAAA
ERFWEELNAV MRALRDLQEN LDSQEPPAVE PQAIHQQQEV LHEIRQEMEQ TKPEVEQCRQ
AGQDLMQLCG EPDKPEVKRH IEDLDSAWEN VTSLYAKREQ NLIDAMDKAM EFHDTLQNLL
EFLDTAEEKY STLGPVASDI DAVKSQIGQL RDFKREVDPH MVEVESLNRQ AKELVEHTSA
NQARAIREPM DDINRRWTAL LKGLVDRQRE LENALLRLGQ FQHALNELLV WISKTEKTLE
DCRPVAGDAQ VIEVELAKHK VLMNDIQAHQ TSVDTLNRAG HQLIEADRHS EDASATQTKL
NNLNRRWQTL QDKAAERQRQ LEAALKEAQA FNQEIQDLLM WLGDVDGQLA SSKPVGGLPE
TAREQLNRFM ELYNELDSNR HRVESALQQG QEYTKVAEGT TTTALQHSLR TLKQRWDNVL
NRANDRKIKL EIALKEATEF HESLQEFVEW LTNSEKYLTN LKPVSRILEN VLVQIEEHKT
FQKDVGAHRE TMLNLDKKGT HLKYFSQKQD VILIKNLLIS VQHRWERVVS KAAERTRSLD
HGYKEAKEFH DSWAELDRWL AEAERSLDDQ PAAGNDPDKI RRLLARHKEF QRALGAKQPA
YDACVRQGRL LKERCPKADL PVLQRMLDDL KARWNAVCNK SVDRQRKLEE ALLFSGQFKD
AVQALIDWLD KALGTLKEDQ LVHGDLDTVN NLVEQHKSFQ TELKSRSTNL ESVRRTASEL
LKTASSEDAS NIRHQMSILE SKWETVSKLC ESKQTRLDEA LKQAEQLHKA VHMLLEWLSD
AEMKLRFAGP LPEDEATTRQ QIAEHQQFMR EMDEQQVNKD KTIALAQEIL AKCHPDAVTV
IRHWVTIIQS RWEEVSLWAR QRQQKLEDHL RSLRDILDLL EELMRWLLGA EATLTALEAQ
PLPDDIPLVE RLIDDHKVFM EDMSKRQPDV DRVSKAFSGK RQQPPAQQPV QQLQQHPVGA
RRRGEPLHHD RRTTPHGASQ STPRTSTPVR GHHAEPEIRH PRAKELVDKW QHVWLLALER
QRRLLERLKY LQELESIKNF DFDEWRRRFL GWMNNKKSRV MDLFRKIDKD NDGKVTKEDF
IDGILKSKFP TSRLEMEKVA DIFDRNGDGY IDHKEYIDTL RPDRDCLVHG ARQNKPLTEA
EKIQDEVQRQ VAKCTCVHRF KVFQVGEGKY RFGESQKLRL VRILRSTVMV RVGGGWVALD
EFLVKNDPCR GGREEALLLT RLIIEQYRRS QSKQFEVQMS PH
//
