ID V5HL05_IXORI Unreviewed; 435 AA.
AC V5HL05;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Putative prolow-density lipoprotein receptor-related protein 1 {ECO:0000313|EMBL:JAB84415.1};
DE Flags: Fragment;
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB84415.1};
RN [1] {ECO:0000313|EMBL:JAB84415.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB84415.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GANP01000053; JAB84415.1; -; mRNA.
DR AlphaFoldDB; V5HL05; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF67; PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1-LIKE PROTEIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00135; LY; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS51120; LDLRB; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:JAB84415.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:JAB84415.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 250..290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 377..422
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 2..14
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 9..27
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 46..58
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 53..71
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 129..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 136..154
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 176..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 215..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 222..240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 234..249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAB84415.1"
FT NON_TER 435
FT /evidence="ECO:0000313|EMBL:JAB84415.1"
SQ SEQUENCE 435 AA; 48353 MW; 4A4319FCE8224322 CRC64;
SCPAMSFRCL NGLCIPDSWR CDRDMDCEDG QNGTLSSDEL DCEYKCARDQ FQCKDGECIS
LLSRCDGHPD CSDSSDEPPA CRVRPCGENE FKCNSTGQCI PKAWMCDGAG DCSDGSDEHL
DLKCPVRTCK PSEFRCLNQV CIQESYYCDG DQDCEDGSDE PSTCEKRRCR EDQFTCGNGR
CISRHALCNG WEDCRDGSDE RSDVCHEADP KVSGCPEGHF KCANKICVNE SLLCNGENDC
GDFSDENRCN INECELSTHA CWQVCEDLPI GYNCSCHPGF KPKNEGRICE DVDECATQYP
CTHFCRNTYG SFACSCADGY FSVDGGRTCK ANSPVKASLL LSNRYYIRQV DLHRMSSDIL
AQNLTNSVAL DFDSVDNCIY WSEVTAVGSS IKRMCLNGSQ EHQVLHSTTV QNPDGLAVDW
VGRNLYWCDK GKDTI
//
