ID V5I2S0_BYSSN Unreviewed; 566 AA.
AC V5I2S0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=L-ornithine N(5)-monooxygenase {ECO:0000256|ARBA:ARBA00018612};
DE EC=1.14.13.196 {ECO:0000256|ARBA:ARBA00012881};
DE AltName: Full=L-ornithine N(5)-oxygenase {ECO:0000256|ARBA:ARBA00030351};
GN ORFNames=PVAR5_5943 {ECO:0000313|EMBL:GAD97270.1};
OS Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces
OS variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=1356009 {ECO:0000313|EMBL:GAD97270.1, ECO:0000313|Proteomes:UP000018001};
RN [1] {ECO:0000313|Proteomes:UP000018001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=No. 5 / NBRC 109023 {ECO:0000313|Proteomes:UP000018001};
RX PubMed=24407650; DOI=10.1128/genomeA.01162-13;
RA Oka T., Ekino K., Fukuda K., Nomura Y.;
RT "Draft genome sequence of the formaldehyde-resistant fungus Byssochlamys
RT spectabilis No. 5 (anamorph Paecilomyces variotii No. 5) (NBRC109023).";
RL Genome Announc. 2:E0116213-E0116213(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC NAD(+); Xref=Rhea:RHEA:41512, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:46911, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC ChEBI:CHEBI:78275; EC=1.14.13.196;
CC Evidence={ECO:0000256|ARBA:ARBA00001398};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC NADP(+); Xref=Rhea:RHEA:41508, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:46911, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:78275; EC=1.14.13.196;
CC Evidence={ECO:0000256|ARBA:ARBA00001847};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD97270.1}.
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DR EMBL; BAUL01000192; GAD97270.1; -; Genomic_DNA.
DR AlphaFoldDB; V5I2S0; -.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006937_7_0_1; -.
DR InParanoid; V5I2S0; -.
DR OrthoDB; 49786at2759; -.
DR Proteomes; UP000018001; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42877; -; 1.
DR PANTHER; PTHR42877:SF14; L-ORNITHINE N(5)-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018001}.
SQ SEQUENCE 566 AA; 64049 MW; AE1039343003950E CRC64;
MSLDTEILII GAGMSGVGFA IQLQKQYPQA RYEIIEKADG LGGTWWVNTY PGCGCDVASH
FYSYSFELNP DWTRKFALQP EIVAYFRSVA EKHDIPRHIV FRSTVQKAEF EERTGTWLVT
ILDQKTGEIY QKRARVLVSA VGALSVPKEC EIKGAERYRE MMFHSAKWDQ GFDWTGKEVV
VIGNGCSATQ FVPILTSGPG KVKKLVQFSR QPHWLAERPN PIYSPAFKFT MRYIPLAMRL
YRFYLYYLME KDFSGFNIVT GSKIRQDLQR TQIEYLRRTA PEKYHDALIP KTEIGLHADP
IEEITENGVR TRSGREVYAD AIILANGFKT QQILHPLEVR GEGGVSLNEH WNTFSSGAPQ
AYYGTCVSQF PNFFIMMGPN TSTGHLSVIY STECQINFTL RVLRPILSSL YPSIWKTPFT
KLGLCSTGPD TVAVTPSAEE NDNTWIQGMA KKLVWASGCT SWYVDENGRN TMLYPDWQFK
YWLRSIFVPL NRDFVFGKSA VKLQAKEEKS VVEKERASKP RLGIRQAVVL ASALGLTISV
VLSANVERRK ADGYVSALRK AVGLMV
//
