ID V5IFI6_IXORI Unreviewed; 911 AA.
AC V5IFI6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 08-NOV-2023, entry version 41.
DE SubName: Full=Putative cask protein {ECO:0000313|EMBL:JAB76096.1};
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB76096.1};
RN [1] {ECO:0000313|EMBL:JAB76096.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB76096.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; GANP01008372; JAB76096.1; -; mRNA.
DR AlphaFoldDB; V5IFI6; -.
DR GO; GO:0030054; C:cell junction; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12081; SH3_CASK; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR035473; CASK_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF7; PERIPHERAL PLASMA MEMBRANE PROTEIN CASK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..300
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 363..418
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 422..477
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 512..593
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 599..668
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 724..896
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 911 AA; 103074 MW; 6EB2ABD724BA6D79 CRC64;
MADEDVVFDD VYEMHEFIGK GPFSVVRRCV HKTTGQQFAV KVVDVAKFTS CPGLGTEDLK
REATICHMLK HPHIVELLET YSSEGMLYMV FEYMEGADLC FEIVKRATAG FVYSEAVSSH
YMRQILEALR YCHENDIIHR DIKPHCVLLA TRENSAPVKL GGFGAAIQLE CDYIYSGEKA
MSIYGENLSL ACRKYFKCDL LGRIGTPHFM APEVVQRKPY GKPADVWSCG VLLYVLLTGT
LPFLGTKERL HEAICSGKLN LTGRQWDQIS EYGKDVIQRM LCLDPRDRYT VEELLNHPWL
KDRDHCAPRV HLQETVDELR KFNARRKLKG AVLAAVSSSK WTSFYSDPAM DGISDFGIEE
EVTAIAVSTV LDSLDDIHCL TDCSERDRDF LLSVLEDSQL HALLDLYDRI NTSSCSPIKC
PPSDACGRAR DVLEWIQDCP LGVTADMEEL QAILCKPHVR ALLQAHDVVS HEVYSEEAIR
VTPPPMMPYL NGSQSADTPS DTDMEQVTRV RLVQFQKNTD EPMGITLKLD EDGRCIVARI
MHGGMIHRQA TLHVGDEIRE INGISVANQT VESLQRMLRD ARGSVTFKII PSYRSAPPPC
EIYVRAQFDY NPLDDDLIPC AQAGIAFQIG DILQVISKDD HNWWQAKKET ADGTAGLIPS
PELQEWRSAC IAMEHSKNDQ VNCSIFGRKK KHFKDKYLAK HNSMFDQLDV VTYEEVVKLP
SFHRKTLVLL GAHGVGRRHI KNTLISSYPN KYAYPIPHTT RLPRKGEENG RNYFFVSHEE
MMADIESHEY LEYGTHEEAM YGTKLDTIRK IHADGKIAIL DVEPQALKIL RTAEYSPYVV
FIAAPSITTM HDVDGSLERL AKESELLRQA YGHFFDLTVV NNDIEDTIHT LEATLDTLDA
SPQWLPVAWV Y
//
