ID V5IK32_IXORI Unreviewed; 909 AA.
AC V5IK32;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Putative neutral sphingomyelinase n-smase activation associated factor fan {ECO:0000313|EMBL:JAB84076.1};
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB84076.1};
RN [1] {ECO:0000313|EMBL:JAB84076.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB84076.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
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DR EMBL; GANP01000392; JAB84076.1; -; mRNA.
DR AlphaFoldDB; V5IK32; -.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF162; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 179..277
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 281..568
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 623..664
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 749..782
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 792..833
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 873..909
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 909 AA; 102998 MW; EE34178D71C18A65 CRC64;
MAFMDSPNSE RFSLLLLEPG EIYFKDYSVY LYPDNVSEAE ARRRCQKGRL KICSKSLLFV
PEDVNQPILK FPLNESSIVE RWTGPLMSKL YSKNSVMSLK NDQVVEMLEG NFIRPYVFKR
KRVAYLFSLT YGSIEECCRH ISQLTRASTL SAAEHDVMVA AMVLSWQSRI TFDRSCLEDL
TEEIVLETKA SKITPLVTNP GLVLLTSLRL YFQPFNNVEP WPHLKINLCE VQRVIRRRFL
LRPVGLELYC SESALLKHLF LSFKTREDRD RVYDLLMRQP ALQLDDKGQE NMTLMWQNGL
VSNYDYLLYI NSLADRSFND LTQYPVFPWV IGDYSSNTLD LTKDSSYRDL SRPLGALSEL
RLKKLKDRYA EMGEPKFLYG SHYSTPGFVL YYLVRKMPQY MLCLQNGHFD RPDRMFNSIP
DTWRNVTTDA ADFKELIPEF YDTASKGDFL INFLNLDFGR KQTGEAVGDV ELPPWAKDPA
HFIHTCREAL ESNFVSENLH NWIDLVFGYK QTGEEAVKAD NVFFHLTYEG SIDLDHITDI
HERHSLEVQI MEFGQTPRCI FSKPHPQRFC TILPRSLSMN DDTSVETADM ENAVTDGARH
PRSSSLVFTW QRDMAQLSKV AEHSLHKETV TDVCFSRDKK SVFSVSQDRL LKLYSLELKQ
QIRSTSISQM ALSSCILMND HTVVVSSWDN YVYVYNMEYG RVTESIMAHN DAVSHLCWKN
GVLATASWDC VAKVWGMGNG RGHSQLLAEL EHEAGVMCVS LDEEASHLAS GTVEGCISVW
HLGDLPVCLG QFQVHDGSVS GVSFSPDGNR VASCSEDETL KVVDVRTGTV LFSKGAGEPL
RSLCWDGATV LTGCRSGCLL VWDLLGGHAP RRHTAHSGAL TCVAAMDDGS LVATGGEDGK
VMVWHPPEA
//
