ID V5IN31_NEUCR Unreviewed; 612 AA.
AC V5IN31;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 03-MAY-2023, entry version 38.
DE SubName: Full=ATP-dependent Clp protease, variant {ECO:0000313|EMBL:ESA43553.1};
GN ORFNames=NCU05427 {ECO:0000313|EMBL:ESA43553.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA43553.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA43553.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002237; ESA43553.1; -; Genomic_DNA.
DR RefSeq; XP_011393579.1; XM_011395277.1.
DR AlphaFoldDB; V5IN31; -.
DR EnsemblFungi; ESA43553; ESA43553; NCU05427.
DR GeneID; 3879398; -.
DR VEuPathDB; FungiDB:NCU05427; -.
DR OrthoDB; 452393at2759; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR48102:SF7; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48102; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:ESA43553.1};
KW Protease {ECO:0000313|EMBL:ESA43553.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 215..401
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 481..563
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT REGION 47..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 68139 MW; AA081B6BBD6248CD CRC64;
MLVLPRAVRR ASSVAVPIMF AARTPASQHL ARLRYISYSS RLALSPRRSQ SYNNQGFSSS
YDPNQENGRG PIFSNKASFG VPQFYPRDLK RRVDDYVVGQ DRAKKTICSV IFNHYQNIRR
RQHHEIQDQR QREKLQRQRY ARDHRDLQDR EGYSGSSRDI HPVEDEFPGH HESVLGTHRD
RDRDHPLAED HFETPSVDDF YIPEDTNAPQ RVKIDKSNLL LIGPTGVGKT YILETLSKKL
NVPFTISDCN SFTQAGYIGQ DVEACIERLL IEANYDVKAA EHGIVVLDEF DKIARRETVN
GRDVGGEGVQ QALLKLVEGT KVTVSVKDHR SSRPPPPPNL NISTPGYGPT STTPSATPGK
VEQYIVDTSN ILFVFCGAFV GLDKTVLRRV AKPSIGFGAE VRNHRGSSMS SSQDILPPEL
YSHLPHQPPT MPVDLSGGSL ASHGAGGFTP LDLASPADLQ AFGFIPELIG RLHNICALSP
LSLDELYRIL TEPRNSLVAQ YTALFETYPS KLYFTRKALY AIAERAAKNE TGARGLKMEM
ERVLAEPMYD APMPYVLITE GCVKGTEKAG YWGKDGRLEL ERMMAEEDQK GLGQGPVEGG
FERMREAGQS GA
//
