ID V5IRM6_NEUCR Unreviewed; 1872 AA.
AC V5IRM6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN Name=cr-1 {ECO:0000313|EMBL:ESA44141.1};
GN Synonyms=nac {ECO:0000313|EMBL:ESA44141.1};
GN ORFNames=NCU08377 {ECO:0000313|EMBL:ESA44141.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA44141.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA44141.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Plays essential roles in regulation of cellular metabolism by
CC catalyzing the synthesis of a second messenger, cAMP.
CC {ECO:0000256|ARBA:ARBA00003896}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; CM002236; ESA44141.1; -; Genomic_DNA.
DR RefSeq; XP_011393196.1; XM_011394894.1.
DR EnsemblFungi; ESA44141; ESA44141; NCU08377.
DR GeneID; 3881413; -.
DR VEuPathDB; FungiDB:NCU08377; -.
DR OrthoDB; 1698689at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd00143; PP2Cc; 1.
DR CDD; cd17214; RA_CYR1_like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR013716; Adenylate_cyclase_G-a-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE-RELATED; 1.
DR Pfam; PF08509; Ad_cyc_g-alpha; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00789; Ad_cyc_g-alpha; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00364; LRR_BAC; 13.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00332; PP2Cc; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS51746; PPM_2; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 321..413
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1124..1400
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT DOMAIN 1464..1601
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1848..1864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1872 AA; 208945 MW; 5848AD465166848B CRC64;
MSADIARYGE APVRTSLTGP DRDRYIDSSQ NPPKTSSSAR SGHSIVHLPG HHKHNKSNED
PRALKPSLSR EDSAASFARD FRNGSSSMMG TRSRAQSPAP SWTGTSRGLK ANSISDGTSS
PAPSHKKGIL GRFRRHNKDK EDGSSLRSGS NHTLVHRPSR QDLTRAAEST YPASVYVSDP
SEQREVPVRP GYVRQTTAPG FTTKLFTSKK SSSAKQPQDD MDEDIGPTDM HMGGGTVYHL
DTNLNDMEGI LTKPQPMTPL DNSISMRRES EKMIVPITTD PEGAWAAPDS WAVRDNKKSL
APQVNEDLCS RQPSEEKEKK SNYYIRVFRS DSTWTTLTLP LTATAEDVIM GVAKKTYLPP
GAQDSYSLLI KKHDLFRVLN SAEQPLRIQK RLFQQIGYQE KDGIDEIGRE DNSYICRWVF
LKEKEADMHL LSPDINFRNQ KLNHVDLSGR NLITIPVPLY RKAAEIVSLN LSRNLSLDVP
RDFIQACTAL RDIKYNNNEA QALPKSFATA SKLTYLDVSN NRLQDLDHSE LSKLTGLLKL
NLANNCLRSL PPTLGAYKSL RTLNISSNFL DVFPSFICEL ETIVDLDLSF NSINNLPDNL
MKLRNLEKFV ITNNRLSGPI SESVRDLVSL RELDIRYNQI STIDVLSDLP RLEILSADHN
QISKFSGSFE RLRSLKLNSN PIVKFEVKAP VPTLKILNLS NAQLASIDES IDNLMNLERL
ILDSNYFVSL PNQIGNLKKL DHLSMANNHL GELPPEIGCL TELRTLDVHG NNMRKLPNEI
WWANKLEHLN ASSNILTEFP KPASRAPQAP GEASPSPGAY PFPNANKNGL LSRTPSMDDL
NGDASRRPSQ ASSTLLGVAV SPVPSGPDNR KSSMVSLYGK GGRKTSVVSR STTQSSTGVI
TPSNGPRKDS SLSYRFTHTF SGSLKNLYLA DNQLDDDVFE ELKHLPELRV LNLSCNDLSD
MPQGTIRSWP QLVELYLSGN ELTSLPAEDF LEEHCLLQTL HINGNKFINL PAEISRAKKL
QVLDCSSNNL KYNVTNVPYD WNWNFNRDLR YLNLSGNKRL EIKNNYRQPQ SYRDDDFADT
DFSKLTNLRV LGLMEVTHTL PNIPDQTEDR RVRTSEMKAG AYLPYGMADT LGKNEHLSLF
DLVVPRLGSV ETDTLVALFD GKELSTGGSK IAKFLYEEFS RLFILELEKV KGKPNENPAD
ALRRTFLSVN KLLMSLSNSA DERGLDSHPS RNYAHTVLTK EDLNSGCVAT VAYLSELKLY
VANVGDVQGM LIQANGSFKM LTKKHDPADP VERSRIRNAG GWVSRNGRLN DVLNVSRAFG
YTELLPAVQA APDITEHTID DKDETVLIAS KELWEHLRPE LIVDVARECR SDLMKASQKL
RDLAIAYGST NKLLIMMIGV ANLKQRQAQQ FKGQLNATFS MPQDDPSHVP PSGNKRRKVR
AEGPLDSNLM RLNAEVPPPT GQLSIVFTDI KNSTQLWENY PEAMRLAIKL HNEVMRRQLR
MIGGFEVKTE GDAFMVSFPT ATSALLWCFA VQMKLLTVDW PPEVLSNSSC QPIYDRNNNL
ITRGLSVRMG AHWGEPLAER DPVTRRMDYY GPMVNKASRI SAVADGGQIT ASSDFITEIH
RCLETYKESV DVDEDSLEDD ATAKAIRAEL RALSSQGFEV KDMGEKKLKG LENPELVYSV
YPHALVGRTE QHHAHTESTQ NQAALQPYGA LATPKPATMD PDSEIQFEPE TIWALWRVAL
RLEMLCSTLE EPNARGLQAP ETELLERMKQ RAGEVTDHFL LNFMEHQISR IETCITSLAV
RHIAIGSGPI TKLNDLRAPM NDVLSTLKEQ MDELARYKAK YGSLDQAETD DATDNNSSGD
VDTLDGSDTE QE
//