ID V5KUG6_9NEOB Unreviewed; 225 AA.
AC V5KUG6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AHA37033.1};
OS Petropedetes vulpiae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Petropedetidae; Petropedetes.
OX NCBI_TaxID=713473 {ECO:0000313|EMBL:AHA37033.1};
RN [1] {ECO:0000313|EMBL:AHA37033.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E151.17 {ECO:0000313|EMBL:AHA37030.1}, E167.14
RC {ECO:0000313|EMBL:AHA37031.1}, E172.18 {ECO:0000313|EMBL:AHA37032.1},
RC E189.14 {ECO:0000313|EMBL:AHA37033.1}, E206.8
RC {ECO:0000313|EMBL:AHA37035.1}, and E91.19
RC {ECO:0000313|EMBL:AHA37029.1};
RX PubMed=24239613; DOI=10.1016/j.ympev.2013.11.001;
RA Barej M.F., Rodel M.O., Loader S.P., Menegon M., Gonwouo N.L., Penner J.,
RA Gvozdik V., Gunther R., Bell R.C., Nagel P., Schmitz A.;
RT "Light shines through the spindrift--phylogeny of African torrent frogs
RT (Amphibia, Anura, Petropedetidae).";
RL Mol. Phylogenet. Evol. 71:261-273(2014).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; KF693527; AHA37029.1; -; Genomic_DNA.
DR EMBL; KF693528; AHA37030.1; -; Genomic_DNA.
DR EMBL; KF693529; AHA37031.1; -; Genomic_DNA.
DR EMBL; KF693530; AHA37032.1; -; Genomic_DNA.
DR EMBL; KF693531; AHA37033.1; -; Genomic_DNA.
DR EMBL; KF693533; AHA37035.1; -; Genomic_DNA.
DR AlphaFoldDB; V5KUG6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 121..225
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHA37033.1"
FT NON_TER 225
FT /evidence="ECO:0000313|EMBL:AHA37033.1"
SQ SEQUENCE 225 AA; 25429 MW; B7E69CA45E66188E CRC64;
SCMKAAPMKE ASVRRQSGLA YPGLRTHGTL ENIGGPMSGS RGGGLPSLTD TFEQVIEELL
EEEQTIRQSE ENKDSDMYSS RVMLSTQVPL EPPLLFLLEE YKNYLDAANM SMRVRRHSDP
ARRGELSVCD SISEWVTAAD KKTAVDMTGQ TVTVLEKVPV PKGQLKQYFY ETKCNPMGYM
KDGCRGIDKR YWNSQCRTTQ SYVRALTMDS KKKVGWRFIR IDTSC
//
