ID   V5N6J3_STIJA            Unreviewed;       300 AA.
AC   V5N6J3;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Myeloid differentiation factor 88 {ECO:0000313|EMBL:AHA83603.1};
DE   SubName: Full=Myeloid differentiation primary response protein 88 {ECO:0000313|EMBL:AGW25455.1};
GN   Name=MyD88 {ECO:0000313|EMBL:AHA83603.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:AHA83603.1};
RN   [1] {ECO:0000313|EMBL:AGW25455.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhou Z., Sun H.;
RT   "MyD88-dependent pathways in Apostichopus japonicus.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AHA83603.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23886491;
RA   Lu Y., Li C., Zhang P., Shao Y., Su X., Li Y., Li T.;
RT   "Two adaptor molecules of MyD88 and TRAF6 in Apostichopus japonicus Toll
RT   signaling cascade: molecular cloning and expression analysis.";
RL   Dev. Comp. Immunol. 41:498-504(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; KC310449; AGW25455.1; -; mRNA.
DR   EMBL; KF032818; AHA83603.1; -; mRNA.
DR   AlphaFoldDB; V5N6J3; -.
DR   SMR; V5N6J3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR   CDD; cd08312; Death_MyD88; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR034249; MyD88_Death.
DR   InterPro; IPR017281; Myelin_different_resp_MyD88.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR15079; MYD88; 1.
DR   PANTHER; PTHR15079:SF3; MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198}.
FT   DOMAIN          56..119
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   DOMAIN          167..298
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   300 AA;  34689 MW;  9958713EA8A9C2DE CRC64;
     MAERPRSISS LSTIPAGDKG NNSTIDWHDI PVLALGPTVR NKLSLYLNRE LDTAKDWRYL
     AEILDYETLD IQNWERRRDP TRELLNNWGS KRGSSVGKLL DNIHLIERED VIEDIGILIE
     SDVTKWVRKR EEERRNVQDP EVSSVSPNFS QDEFSRITIQ DNEDDSQKFD AFVCYCLDDH
     PFVQEMISVL EGKEKLKLYI QYRDLLPGGS HTTVTAELIE NRCRRMVVVL SPQFKEDDFN
     NFCIKFGISL QPGGQSKKVI PVIVSPCKLP SILQHLTVLD YTKKDLRPWF WNRLASAIKL
//