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Database: UniProt
Entry: V5R499_9INFA
LinkDB: V5R499_9INFA
Original site: V5R499_9INFA 
ID   V5R499_9INFA            Unreviewed;        82 AA.
AC   V5R499;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   08-NOV-2023, entry version 24.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE   Flags: Fragment;
GN   Name=PB1 {ECO:0000313|EMBL:AHB24619.1};
OS   Influenza A virus (A/swine/North Carolina/SG1393/2011).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC   Alphainfluenzavirus influenzae; Influenza A virus.
OX   NCBI_TaxID=1423169 {ECO:0000313|EMBL:AHB24619.1};
RN   [1] {ECO:0000313|EMBL:AHB24619.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/swine/North Carolina/SG1393/2011
RC   {ECO:0000313|EMBL:AHB24619.1};
RA   Wentworth D.E., Dugan V., Halpin R.A., Lin X., Bera J., Wester E.,
RA   Ghedin E., Fedorova N., Tsitrin T., McLellan M., Stockwell T., Amedeo P.,
RA   Appalla L., Bishop B., Edworthy P., Gupta N., Hoover J., Katzel D., Li K.,
RA   Schobel S., Shrivastava S., Thovarai V., Wang S., Detmer S., Bao Y.,
RA   Sanders R., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.;
RT   "The NIAID Influenza Genome Sequencing Project.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AHB24619.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/swine/North Carolina/SG1393/2011
RC   {ECO:0000313|EMBL:AHB24619.1};
RG   The NIAID Influenza Genome Sequencing Consortium;
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC       replication and transcription of virus RNA segments. The transcription
CC       of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC       methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC       by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC       transcription of viral mRNAs. During virus replication, PB1 initiates
CC       RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC       serves as a template for the production of more vRNAs.
CC       {ECO:0000256|ARBA:ARBA00002148}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC       {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CY160117; AHB24619.1; -; Viral_cRNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
PE   4: Predicted;
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00023103};
KW   Eukaryotic host transcription shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00022731};
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00023103};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Inhibition of host RNA polymerase II by virus
KW   {ECO:0000256|ARBA:ARBA00023103};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT   REGION          50..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         82
FT                   /evidence="ECO:0000313|EMBL:AHB24619.1"
SQ   SEQUENCE   82 AA;  8932 MW;  385EF02F62A21019 CRC64;
     MDVNPTLLFL KVPAQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS EKGKWTTNTE
     TGAPQLNPID GPLPDDNEPS GY
//
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