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Database: UniProt
Entry: V5RJ70_SPIAP
LinkDB: V5RJ70_SPIAP
Original site: V5RJ70_SPIAP 
ID   V5RJ70_SPIAP            Unreviewed;       443 AA.
AC   V5RJ70;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AHB35850.1};
GN   ORFNames=SAPIS_v1c00010 {ECO:0000313|EMBL:AHB35850.1};
OS   Spiroplasma apis B31.
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales;
OC   Spiroplasmataceae; Spiroplasma.
OX   NCBI_TaxID=1276258 {ECO:0000313|EMBL:AHB35850.1, ECO:0000313|Proteomes:UP000018550};
RN   [1] {ECO:0000313|EMBL:AHB35850.1, ECO:0000313|Proteomes:UP000018550}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B31 {ECO:0000313|EMBL:AHB35850.1};
RX   PubMed=24407648;
RA   Ku C., Lo W.S., Chen L.L., Kuo C.H.;
RT   "Complete Genome Sequence of Spiroplasma apis B31T (ATCC 33834), a
RT   Bacterium Associated with May Disease of Honeybees (Apis mellifera).";
RL   Genome Announc. 2:e01151-13(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP006682; AHB35850.1; -; Genomic_DNA.
DR   RefSeq; WP_023788784.1; NC_022998.1.
DR   EnsemblBacteria; AHB35850; AHB35850; SAPIS_v1c00010.
DR   KEGG; sapi:SAPIS_v1c00010; -.
DR   PATRIC; fig|1276258.3.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000018550; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018550};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018550}.
FT   DOMAIN      134    268       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      351    420       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     142    149       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   443 AA;  50950 MW;  14D545F3A57D7A98 CRC64;
     MTNEELWKKI KEWLIESDSI EPNIYDEYIK TAMLRRLSEQ HLVVIVKTEL SKWYLENILS
     VMRSKASFFL ENDVDLSLMT NEEYEKELNI TELIEQKRKK LKSQDFMFEN FIFGSSNMNA
     YKASKAIVEN IGTKWNPLFI YGDSGLGKTH LLKAIAHEIG NTKNKLVVKY YTSSDFRKEI
     VDSLQDGFKE IESTKEKLSK IDVLLIDDIQ FLANSGKTNE IFFNLFNFFI ENNKQIVLTS
     DKFPEQLNGF DKRLVSRFSQ GLNVKVETPD IITAINIVDY KAKIVNLNLS EESKKYIASF
     FGSDVRKIEG IINKIEFSII QDNSAAPKII ELEDINKFLE DYSFAPGGEI TVQKIKNVVA
     QNYGISVKSI DSRLRMANIV KARHVAMFLT GEILKKNYSE IGVAFGGKDH TTVLHAFKKI
     NDLLEKDKIF KKTLTKIKKE ITS
//
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