ID   V5TQF8_HALHI            Unreviewed;       459 AA.
AC   V5TQF8;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=L-cysteine desulfhydrase {ECO:0000313|EMBL:AHB67172.1};
DE            EC=4.1.99.1 {ECO:0000313|EMBL:AHB67172.1};
GN   Name=tnaA {ECO:0000313|EMBL:AHB67172.1};
GN   ORFNames=HISP_14600 {ECO:0000313|EMBL:AHB67172.1};
OS   Haloarcula hispanica N601.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=1417673 {ECO:0000313|Proteomes:UP000018572};
RN   [1] {ECO:0000313|EMBL:AHB67172.1, ECO:0000313|Proteomes:UP000018572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N601 {ECO:0000313|EMBL:AHB67172.1,
RC   ECO:0000313|Proteomes:UP000018572};
RX   PubMed=24625874;
RA   Ding J.Y., Chiang P.W., Hong M.J., Dyall-Smith M., Tang S.L.;
RT   "Complete Genome Sequence of the Extremely Halophilic Archaeon Haloarcula
RT   hispanica Strain N601.";
RL   Genome Announc. 2:e00178-14(2014).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the beta-eliminating lyase family.
CC       {ECO:0000256|ARBA:ARBA00009721}.
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DR   EMBL; CP006884; AHB67172.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5TQF8; -.
DR   KEGG; hhn:HISP_14600; -.
DR   HOGENOM; CLU_047223_0_0_2; -.
DR   Proteomes; UP000018572; Chromosome 1.
DR   GO; GO:0009034; F:tryptophanase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR   InterPro; IPR011166; Beta-eliminating_lyase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR32325; BETA-ELIMINATING LYASE-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32325:SF4; TRYPTOPHANASE; 1.
DR   Pfam; PF01212; Beta_elim_lyase; 1.
DR   PIRSF; PIRSF001386; Trpase; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:AHB67172.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT   DOMAIN          54..421
FT                   /note="Aromatic amino acid beta-eliminating lyase/threonine
FT                   aldolase"
FT                   /evidence="ECO:0000259|Pfam:PF01212"
SQ   SEQUENCE   459 AA;  50306 MW;  CA2B22C48687D6F8 CRC64;
     MGNKSIGVLR HSMRSYKAKS VTSIQLPPRE RRETALSEAG HNVFNLAADD VFIDLLTDSG
     TGAMSDDQWA DVVRGDEAYA GSRSFERFRE AVADVMGFDR VVPTHQGRGA ENVLFGALLD
     EGDVVLNNTH FDTTRAHVTN QGAIAVDCPA ETDLTTDSVG TFAGNFDTDR GWDAVEEYGQ
     DAVSAVVLTI TNNSAAGQPV SMANIRETAA FATEIDVPFV IDACRFAENA QFIKQRDPEY
     ADTPLSEIAR EQLRPADAIT MSGKKDALAN IGGFTAVRDA ALFERCKQRA ILYEGFPTYG
     GLAGRDLEAM ATGLREAVQP PYVAERIEQV ATLGDLLRER DIPIVTPTGG HAVYIDAAAL
     LPDIPADQFP GQRLVCELYR EGGVRTVELG SFAFPGTDRP ELVRLALPRR TYWREHLEHI
     AETAARVRDC RDEYTGLKIV WEPPMEELRH FSAELEPVA
//