ID V5VH61_ACIBA Unreviewed; 534 AA.
AC V5VH61;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Isocitrate lyase {ECO:0000256|ARBA:ARBA00017446};
DE AltName: Full=Isocitrase {ECO:0000256|ARBA:ARBA00031022};
DE AltName: Full=Isocitratase {ECO:0000256|ARBA:ARBA00031921};
GN Name=aceA {ECO:0000313|EMBL:AKA32602.1};
GN ORFNames=A0141_RS03665 {ECO:0000313|EMBL:EHU2483338.1}, A7M90_10985
GN {ECO:0000313|EMBL:OIG67117.1}, Aba7835_14435
GN {ECO:0000313|EMBL:QFY69787.1}, ABCAM1_1022
GN {ECO:0000313|EMBL:QEY03531.1}, ABR2091_0996
GN {ECO:0000313|EMBL:CUW34403.1}, ABUW_2888
GN {ECO:0000313|EMBL:AKA32602.1}, ACX61_13980
GN {ECO:0000313|EMBL:AKQ31467.1}, APD17_04400
GN {ECO:0000313|EMBL:KQD52857.1}, AUO97_12255
GN {ECO:0000313|EMBL:APP31540.1}, AYR68_04800
GN {ECO:0000313|EMBL:AML66366.1}, B7L45_13925
GN {ECO:0000313|EMBL:ARG02803.1}, B9W25_14235
GN {ECO:0000313|EMBL:PRN32691.1}, B9X95_12550
GN {ECO:0000313|EMBL:OTM84511.1}, C2U32_01340
GN {ECO:0000313|EMBL:AUT36744.1}, CBE85_06975
GN {ECO:0000313|EMBL:OWK67171.1}, CBL15_13005
GN {ECO:0000313|EMBL:AWW85878.1}, CSB70_0729
GN {ECO:0000313|EMBL:AVI32005.1}, CTZ19_13885
GN {ECO:0000313|EMBL:ATU57208.1}, CV954_014405
GN {ECO:0000313|EMBL:PQL81402.1}, D8O08_019700
GN {ECO:0000313|EMBL:QBF38414.1}, DLI71_06170
GN {ECO:0000313|EMBL:QFX71257.1}, DOL94_17885
GN {ECO:0000313|EMBL:PZM09271.1}, E1A86_06140
GN {ECO:0000313|EMBL:QBM40298.1}, E1A87_01235
GN {ECO:0000313|EMBL:QBM42859.1}, EA706_11260
GN {ECO:0000313|EMBL:RSQ43240.1}, EA720_005385
GN {ECO:0000313|EMBL:QBH53190.1}, EA722_01885
GN {ECO:0000313|EMBL:RSP81077.1}, EGM95_15670
GN {ECO:0000313|EMBL:AYY90127.1}, F2P40_05850
GN {ECO:0000313|EMBL:MQR48855.1}, FDN00_06990
GN {ECO:0000313|EMBL:QCP41638.1}, FE003_14350
GN {ECO:0000313|EMBL:QCT16854.1}, FJV09_02095
GN {ECO:0000313|EMBL:TPS31339.1}, FR761_06195
GN {ECO:0000313|EMBL:QFH44962.1}, G3N53_08655
GN {ECO:0000313|EMBL:NDW41145.1}, GNY86_13160
GN {ECO:0000313|EMBL:MVM92473.1}, GSE42_05575
GN {ECO:0000313|EMBL:MYM77402.1}, HB367_00845
GN {ECO:0000313|EMBL:QJG82646.1}, HIN86_14000
GN {ECO:0000313|EMBL:QJF36271.1}, IAG11_14640
GN {ECO:0000313|EMBL:MBD0221131.1}, IMO23_04950
GN {ECO:0000313|EMBL:QPF14277.1}, ITE13_01575
GN {ECO:0000313|EMBL:MBP4958210.1}, JHZ39_003231
GN {ECO:0000313|EMBL:EGY2378810.1}, P9867_04180
GN {ECO:0000313|EMBL:MDK4880935.1}, SAMEA104305318_00794
GN {ECO:0000313|EMBL:SST18443.1}, SAMEA4394745_02672
GN {ECO:0000313|EMBL:SSI56624.1};
OS Acinetobacter baumannii.
OG Plasmid unnamed1 {ECO:0000313|EMBL:QBF38414.1,
OG ECO:0000313|Proteomes:UP000270202}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=470 {ECO:0000313|EMBL:PZM09271.1, ECO:0000313|Proteomes:UP000248662};
RN [1] {ECO:0000313|EMBL:APP31540.1, ECO:0000313|Proteomes:UP000072389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17978 {ECO:0000313|EMBL:APP31540.1,
RC ECO:0000313|Proteomes:UP000072389};
RX PubMed=25136007; DOI=10.1128/AAC.03074-14;
RA Fernando D.M., Xu W., Loewen P.C., Zhanel G.G., Kumar A.;
RT "Triclosan can select for an AdeIJK-overexpressing mutant of Acinetobacter
RT baumannii ATCC 17978 that displays reduced susceptibility to multiple
RT antibiotics.";
RL Antimicrob. Agents Chemother. 58:6424-6431(2014).
RN [2] {ECO:0000313|EMBL:AKA32602.1, ECO:0000313|Proteomes:UP000032746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB5075-UW {ECO:0000313|EMBL:AKA32602.1,
RC ECO:0000313|Proteomes:UP000032746};
RX PubMed=25845845;
RA Gallagher L.A., Ramage E., Weiss E.J., Radey M., Hayden H.S., Held K.G.,
RA Huse H.K., Zurawski D.V., Brittnacher M.J., Manoil C.;
RT "Resources for Genetic and Genomic Analysis of Emerging Pathogen
RT Acinetobacter baumannii.";
RL J. Bacteriol. 197:2027-2035(2015).
RN [3] {ECO:0000313|EMBL:AKQ31467.1, ECO:0000313|Proteomes:UP000036348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab04-mff {ECO:0000313|EMBL:AKQ31467.1,
RC ECO:0000313|Proteomes:UP000036348};
RX PubMed=26170289; DOI=10.1073/pnas.1502966112;
RA Weber B.S., Ly P.M., Irwin J.N., Pukatzki S., Feldman M.F.;
RT "A multidrug resistance plasmid contains the molecular switch for type VI
RT secretion in Acinetobacter baumannii.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:9442-9447(2015).
RN [4] {ECO:0000313|Proteomes:UP000032746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB5075-UW {ECO:0000313|Proteomes:UP000032746};
RA Gallagher L.A., Hayden H.S., Weiss E.J., Hager K.R., Ramage E., Radey M.R.,
RA Bydalek R., Manoil C., Miller S.I., Brittnacher M.J.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000036348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab04-mff {ECO:0000313|Proteomes:UP000036348};
RA Weber B.S., Ly P.M., Irwin J.N., Pukatzki S., Feldman M.F.;
RT "A multidrug resistance plasmid contains the molecular switch for type VI
RT secretion in Acinetobacter baumannii.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:KQD52857.1, ECO:0000313|Proteomes:UP000051023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABBL067b {ECO:0000313|EMBL:KQD52857.1,
RC ECO:0000313|Proteomes:UP000051023};
RA Ozer E.A., Fitzpatrick M.A., Hauser A.R.;
RT "The utility of whole genome sequencing in characterizing Acinetobacter
RT epidemiology and analyzing hospital outbreaks.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:APP31540.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 17978 {ECO:0000313|EMBL:APP31540.1};
RA Singh M.K., Fernando D.M., Kumar A.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:CUW34403.1, ECO:0000313|Proteomes:UP000066661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R2091 {ECO:0000313|EMBL:CUW34403.1};
RA Wibberg D.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|Proteomes:UP000293712, ECO:0000313|Proteomes:UP000294205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB047 {ECO:0000313|EMBL:QBM40298.1,
RC ECO:0000313|Proteomes:UP000294205}, and AB048
RC {ECO:0000313|EMBL:QBM42859.1, ECO:0000313|Proteomes:UP000293712};
RX PubMed=27917170; DOI=.3389/fmicb.2016.01871;
RA Fernando D.M., Khan I.U., Patidar R., Lapen D.R., Talbot G., Topp E.,
RA Kumar A.;
RT "Isolation and Characterization of Acinetobacter baumannii Recovered from
RT Campylobacter Selective Medium.";
RL Front. Microbiol. 7:1871-1871(2016).
RN [10] {ECO:0000313|EMBL:AML66366.1, ECO:0000313|Proteomes:UP000070545}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH859 {ECO:0000313|EMBL:AML66366.1,
RC ECO:0000313|Proteomes:UP000070545};
RA Feng Y., Hua X., Yu Y.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:OIG67117.1, ECO:0000313|Proteomes:UP000179937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH647 {ECO:0000313|EMBL:OIG67117.1,
RC ECO:0000313|Proteomes:UP000179937};
RA Hua X., Yu Y.;
RT "The evolution of Acinetobacter baumannii in vivo.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:APP31540.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 17978 {ECO:0000313|EMBL:APP31540.1};
RA Singh M., Fernando D., Kumar A.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:MYM77402.1, ECO:0000313|Proteomes:UP000480763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMS06669 {ECO:0000313|EMBL:MYM77402.1,
RC ECO:0000313|Proteomes:UP000480763};
RX PubMed=29137647;
RA Si-Tuan N., Ngoc H.M., Hang P.T.T., Nguyen C., Van P.H., Huong N.T.;
RT "New eight genes identified at the clinical multidrug-resistant
RT Acinetobacter baumannii DMS06669 strain in a Vietnam hospital.";
RL Ann. Clin. Microbiol. Antimicrob. 16:0-74(2017).
RN [14] {ECO:0000313|EMBL:PRN32691.1, ECO:0000313|Proteomes:UP000237823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KUFAR57 {ECO:0000313|EMBL:PRN32691.1,
RC ECO:0000313|Proteomes:UP000237823};
RA Nasser K., Habibi N., Khan M.W., Purohit P., Al-Obaid I., Dhar R.,
RA Al-Fouzan W., Mustafa A.S.;
RT "Comparison of Acinetobacter baumannii whole genome sequences from two
RT major hospitals in Kuwait.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:ARG02803.1, ECO:0000313|Proteomes:UP000192723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAA14 {ECO:0000313|EMBL:ARG02803.1,
RC ECO:0000313|Proteomes:UP000192723};
RA Yoon E.-J., Kim J.O., Yang J.W., Kim H.S., Lee K.J., Jeong S.H., Lee H.,
RA Lee K.;
RT "Multiplied blaOXA-23-transposons in the genome of Acinetobacter spp. as an
RT adaptive mechanism for bacteria encountering carbapenems.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:OWK67171.1, ECO:0000313|Proteomes:UP000197394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB360 {ECO:0000313|EMBL:OWK67171.1,
RC ECO:0000313|Proteomes:UP000197394};
RA Wareham D.W., Bean D.C.;
RT "Draft genome sequence of MDR A. baumannii AB360.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:AWW85878.1, ECO:0000313|Proteomes:UP000249421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH731 {ECO:0000313|EMBL:AWW85878.1,
RC ECO:0000313|Proteomes:UP000249421};
RA Hua X., Yu Y.;
RT "The evolution of oxa-23 in Acinetobacter baumanni.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [18] {ECO:0000313|EMBL:OTM84511.1, ECO:0000313|Proteomes:UP000194699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PR350 {ECO:0000313|EMBL:OTM84511.1,
RC ECO:0000313|Proteomes:UP000194699};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [19] {ECO:0000313|EMBL:ATU57208.1, ECO:0000313|Proteomes:UP000229219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab4568 {ECO:0000313|EMBL:ATU57208.1,
RC ECO:0000313|Proteomes:UP000229219};
RA Liu X.;
RT "Genome analysis of an Acinetobacter baumannii outbreak in hospital ICU in
RT China.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [20] {ECO:0000313|Proteomes:UP000236385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RX PubMed=29437920;
RG NISC Comparative Sequencing Program;
RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT Bacterial Plasmids Conferring Carbapenem Resistance.";
RL MBio 9:e02011-e02017(2018).
RN [21] {ECO:0000313|EMBL:AUT36744.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT36744.1};
RG NISC Comparative Sequencing Program;
RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT Bacterial Plasmids Conferring Carbapenem Resistance.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [22] {ECO:0000313|EMBL:AUT36744.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT36744.1};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [23] {ECO:0000313|Proteomes:UP000236385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RA Segre J.A., Mullikin J.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [24] {ECO:0000313|EMBL:PQL81402.1, ECO:0000313|Proteomes:UP000233757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZQ8 {ECO:0000313|EMBL:PQL81402.1,
RC ECO:0000313|Proteomes:UP000233757};
RA Qasim Z.J.;
RT "Acinetobacter baumanii whole genome sequence.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [25] {ECO:0000313|EMBL:AVI32005.1, ECO:0000313|Proteomes:UP000257523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR_0070 {ECO:0000313|EMBL:AVI32005.1,
RC ECO:0000313|Proteomes:UP000257523};
RA Benahmed F.H., Lutgring J.D., Yoo B., Machado M., Brown A., McAllister G.,
RA Perry A., Halpin A.L., Vavikolanu K., Ott S., Zhao X., Tallon L.,
RA Sadzewicz L., Aluvathingal J., Nadendla S., Voskania-kordi A., Simonyan V.,
RA Patel J., Shawar R.M.;
RT "FDA/CDC Antimicrobial Resistant Isolate Bank Genome Sequencing.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [26] {ECO:0000313|EMBL:PZM09271.1, ECO:0000313|Proteomes:UP000248662}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R10 {ECO:0000313|EMBL:PZM09271.1,
RC ECO:0000313|Proteomes:UP000248662};
RA Bonnin R.A., Levy M., Cuzon G., Dortet L., Naas T.;
RT "Carbapenemase-producing Acinetobacter spp. from environmental sources in
RT an hospital from French Polynesia.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [27] {ECO:0000313|Proteomes:UP000252694, ECO:0000313|Proteomes:UP000262697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4300STDY6542375 {ECO:0000313|EMBL:SSI56624.1,
RC ECO:0000313|Proteomes:UP000262697}, and 4300STDY7045823
RC {ECO:0000313|EMBL:SST18443.1, ECO:0000313|Proteomes:UP000252694};
RG Pathogen Informatics;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [28] {ECO:0000313|EMBL:QFY69787.1, ECO:0000313|Proteomes:UP000326952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7835 {ECO:0000313|EMBL:QFY69787.1,
RC ECO:0000313|Proteomes:UP000326952};
RA Salgado-Camargo A.D., Castro-Jaimes S., Silva-Sanchez J.,
RA Volkow-Fernandez P., Castillo-Ramirez S., Cevallos M.A.;
RT "Evolution of Acinetobacter baumannii plasmids.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [29] {ECO:0000313|Proteomes:UP000268766, ECO:0000313|Proteomes:UP000269597}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TG22168 {ECO:0000313|EMBL:RSQ43240.1,
RC ECO:0000313|Proteomes:UP000272401}, TG31299
RC {ECO:0000313|EMBL:RSP81077.1, ECO:0000313|Proteomes:UP000269597}, and
RC TG60155 {ECO:0000313|Proteomes:UP000268766};
RA Sahl J.W.;
RT "GWAS and RNA-Seq identify cryptic mechanisms of antimicrobial resistance
RT in Acinetobacter baumannii.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [30] {ECO:0000313|EMBL:QBH53190.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TG60155 {ECO:0000313|EMBL:QBH53190.1};
RA Sahl J.W.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [31] {ECO:0000313|EMBL:AYY90127.1, ECO:0000313|Proteomes:UP000273577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN15313 {ECO:0000313|EMBL:AYY90127.1,
RC ECO:0000313|Proteomes:UP000273577};
RA Sorenson N.M., Snesrud E., Xavier D.E., Cacci L.C., Oeleman W.,
RA Iavarone A.T., Mc Gann P., Riley L.W., Moreira B.M.;
RT "A novel plasmid carries a functional mcr-4.3 gene in a colistin-resistant
RT Acinetobacter baumannii clinical strain.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [32] {ECO:0000313|EMBL:QBF38414.1, ECO:0000313|Proteomes:UP000270202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VB31459 {ECO:0000313|EMBL:QBF38414.1,
RC ECO:0000313|Proteomes:UP000270202};
RC PLASMID=unnamed1 {ECO:0000313|EMBL:QBF38414.1,
RC ECO:0000313|Proteomes:UP000270202};
RA Veeraraghavan B., Vijayakumar S., Neeravi A., Venkatesan M.;
RT "Carbapenem resistant Acinetobacter baumannii_VB31459_hybrid assembly.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [33] {ECO:0000313|EMBL:QBH53190.1, ECO:0000313|Proteomes:UP000268766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TG60155 {ECO:0000313|EMBL:QBH53190.1,
RC ECO:0000313|Proteomes:UP000268766};
RA Sahl J.;
RT "Comparative genomics and transcriptomics of Acinetobacter baumannii.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [34] {ECO:0000313|EMBL:QBM40298.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB047 {ECO:0000313|EMBL:QBM40298.1}, and AB048
RC {ECO:0000313|EMBL:QBM42859.1};
RA Singh M.K., Patidar R., Khan I., Kumar A.;
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN [35] {ECO:0000313|EMBL:QCP41638.1, ECO:0000313|Proteomes:UP000298622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VB33071 {ECO:0000313|EMBL:QCP41638.1,
RC ECO:0000313|Proteomes:UP000298622};
RA Veeraraghavan B., Vijayakumar S., Vasudevan K., Narasimman V.,
RA Venkatesan M.;
RT "Carbapenem resistant Acinetobacter baumannii_VB33071_hybrid assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [36] {ECO:0000313|EMBL:QCT16854.1, ECO:0000313|Proteomes:UP000300722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB364 {ECO:0000313|EMBL:QCT16854.1,
RC ECO:0000313|Proteomes:UP000300722};
RA Huang W., Wang G., Yin C., Chen D., Dhand A., Chanza M., Dimitrova N.,
RA Fallon J.T.;
RT "Optimizing a Whole-Genome Sequencing Data Processing Pipeline for
RT Precision Surveillance of Healthcare-Associated Infections.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [37] {ECO:0000313|EMBL:TPS31339.1, ECO:0000313|Proteomes:UP000316901}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN7153 {ECO:0000313|EMBL:TPS31339.1,
RC ECO:0000313|Proteomes:UP000316901};
RA Mcgann P., Snesrud E., Galac M.R.;
RT "A Diverse Panel of Clinical Acinetobacter baumannii for Research Use.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [38] {ECO:0000313|EMBL:QFH44962.1, ECO:0000313|Proteomes:UP000327158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E47 {ECO:0000313|EMBL:QFH44962.1,
RC ECO:0000313|Proteomes:UP000327158};
RA Phan H.T.T., Stoesser N., Gordon K.A., Crook D., Walker S.A., Mathers A.J.,
RA Peto T.E.A., George S., Lipworth S.I.;
RT "Genomic Dynamics of Species and Mobile Genetic Elements in a Prolonged
RT blaIMP-4-associated Carbapenemase Outbreak in an Australian Hospital.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN [39] {ECO:0000313|EMBL:QFX71257.1, ECO:0000313|Proteomes:UP000325982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6507 {ECO:0000313|EMBL:QFX71257.1,
RC ECO:0000313|Proteomes:UP000325982};
RA Paul V., Sankar M.J., Gaind R., Ray P., Gautam V., Biswal M., Datta S.,
RA Walia K., Kreiswirth B., Evans S., Fowler V., Patel R., Chambers H.C.,
RA Bonomo R.A., Hujer K.M., Huker A., Adams M., Clarke T.H., Sutton G.,
RA Nierman W.C., Nelson K.E., Fouts D.E.;
RT "10 Multi-Drug Resistant Acinetobacter Baumannii Strains for ARLG-ICMR From
RT India.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [40] {ECO:0000313|EMBL:QEY03531.1, ECO:0000313|Proteomes:UP000326895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAM180-1 {ECO:0000313|EMBL:QEY03531.1,
RC ECO:0000313|Proteomes:UP000326895};
RA Kim Y.-H., Kim B.K.;
RT "Genome sequencing of Acinetobacter baumannii strain CAM180.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [41] {ECO:0000313|EMBL:MQR48855.1, ECO:0000313|Proteomes:UP000461234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABS103 {ECO:0000313|EMBL:MQR48855.1,
RC ECO:0000313|Proteomes:UP000461234};
RA Douraghi M., Aris P., Kenyon J., Hamidian M.;
RT "Genetic environment of the oxa23 gene and comparative analysis of
RT carbapenem resistant Acinetobacter baumannii isolates belonging to global
RT clone 1, lineage 2 recovered in a burns hospital outbreak in 2012-2013.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [42] {ECO:0000313|EMBL:MVM92473.1, ECO:0000313|Proteomes:UP000439424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac576 {ECO:0000313|EMBL:MVM92473.1,
RC ECO:0000313|Proteomes:UP000439424};
RA Fedrigo N.H., Cerdeira L., Fuga B., Marini P.V.B., Shinohara D.R.,
RA Carrara-Marroni F.E., Lincopan N., Tognim M.C.B.;
RT "Multidrug-resistant Acinetobacter baumannii moving toward extensively
RT drug-resistant over fifteen years in South of Brazil.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [43] {ECO:0000313|EMBL:MYM77402.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DMS06669 {ECO:0000313|EMBL:MYM77402.1};
RA Nguyen S.-T.;
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [44] {ECO:0000313|EMBL:NDW41145.1, ECO:0000313|Proteomes:UP000470018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP816 {ECO:0000313|EMBL:NDW41145.1,
RC ECO:0000313|Proteomes:UP000470018};
RA Veeraraghavan B., Mathur P., Vijayakumar S., Vasudevan K., Lincy M.,
RA Kirubananthan A.;
RT "Whole genome shot-gun sequencing of clinical Carbapenem resistant A.
RT baumannii.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [45] {ECO:0000313|Proteomes:UP000503033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM193665 {ECO:0000313|Proteomes:UP000503033};
RA Veeraraghavan B., Vijayakumar S., Amala A., francis L., Kirubananthan A.;
RT "Complete genome sequencing for A.baumanii.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [46] {ECO:0000313|EMBL:QJG82646.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PM193665 {ECO:0000313|EMBL:QJG82646.1};
RA Veeraraghavan B., Vijayakumar S., Amala A., Francis L., Kirubananthan A.;
RT "Complete genome sequencing for A.baumanii.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [47] {ECO:0000313|EMBL:QJF36271.1, ECO:0000313|Proteomes:UP000501210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab-B004d-c {ECO:0000313|EMBL:QJF36271.1,
RC ECO:0000313|Proteomes:UP000501210};
RA Ayibieke A., Saito R.;
RT "Whole-genome sequence analysis of carbapanemase producing Acinetobacter
RT baumannii isolates from Ghana.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [48] {ECO:0000313|EMBL:MBD0221131.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A86 {ECO:0000313|EMBL:MBD0221131.1};
RA Abouelfetouh A., Mattock J., Turner D., Li E., Evans B.A.;
RT "Diversity of carbapenem-resistant Acinetobacter baumannii and
RT bacteriophage-mediated spread of the Oxa23 carbapenemase.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
RN [49] {ECO:0000313|EMBL:QPF14277.1, ECO:0000313|Proteomes:UP000594659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Res13-Abat-PEA21-P4-01-A {ECO:0000313|EMBL:QPF14277.1,
RC ECO:0000313|Proteomes:UP000594659};
RA Poulin-Laprade D., Brouard J.-S., Gagnon N., Turcotte A., Langlois A.,
RA Matte J.J., Carrillo C.D., Zaheer R., McAllister T., Topp E., Talbot G.;
RT "Resistance determinants and their genetic context in bacteria from a
RT longitudinal study of pigs reared under conventional and antibiotic-free
RT husbandry practices.";
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
RN [50] {ECO:0000313|EMBL:MBP4958210.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E314 {ECO:0000313|EMBL:MBP4958210.1};
RA Frenk S., Rakovitsky N.;
RT "Epidemiology and genetic characterization of 247 CRAB isolated from
RT infections.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
RN [51] {ECO:0000313|EMBL:EGY2378810.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=2018HL-00813 {ECO:0000313|EMBL:EGY2378810.1};
RG Clinical and Environmental Microbiology Branch: Whole genome sequencing antimicrobial resistance pathogens in the healthcare setting;
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
RN [52] {ECO:0000313|EMBL:EHU2483338.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MRSN7100 {ECO:0000313|EMBL:EHU2483338.1};
RA Mcgann P.T.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
RN [53] {ECO:0000313|EMBL:MDK4880935.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CPO519 {ECO:0000313|EMBL:MDK4880935.1};
RA Macesic N.;
RT "Genomic dissection of endemic carbapenem resistance: metallo-beta-
RT lactamase gene dissemination through clonal, plasmid and integron transfer
RT pathways.";
RL Submitted (JAN-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-threo-isocitrate = glyoxylate + succinate;
CC Xref=Rhea:RHEA:13245, ChEBI:CHEBI:15562, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:36655; EC=4.1.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00023531};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR001362-3};
CC Note=Can also use Mn(2+) ion. {ECO:0000256|PIRSR:PIRSR001362-3};
CC ---------------------------------------------------------------------------
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DR EMBL; CP008706; AKA32602.1; -; Genomic_DNA.
DR EMBL; CP012006; AKQ31467.1; -; Genomic_DNA.
DR EMBL; CP014539; AML66366.1; -; Genomic_DNA.
DR EMBL; CP018664; APP31540.1; -; Genomic_DNA.
DR EMBL; CP020579; ARG02803.1; -; Genomic_DNA.
DR EMBL; CP024613; ATU57208.1; -; Genomic_DNA.
DR EMBL; CP026125; AUT36744.1; -; Genomic_DNA.
DR EMBL; CP027178; AVI32005.1; -; Genomic_DNA.
DR EMBL; CP021321; AWW85878.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY90127.1; -; Genomic_DNA.
DR EMBL; LN997846; CUW34403.1; -; Genomic_DNA.
DR EMBL; AAYLMQ010000051; EGY2378810.1; -; Genomic_DNA.
DR EMBL; AAYNHF020000002; EHU2483338.1; -; Genomic_DNA.
DR EMBL; LLFO01000106; KQD52857.1; -; Genomic_DNA.
DR EMBL; JACSVK010000041; MBD0221131.1; -; Genomic_DNA.
DR EMBL; JAEHMK010000002; MBP4958210.1; -; Genomic_DNA.
DR EMBL; JARTMM010000009; MDK4880935.1; -; Genomic_DNA.
DR EMBL; WIOC01000005; MQR48855.1; -; Genomic_DNA.
DR EMBL; WPIP01000099; MVM92473.1; -; Genomic_DNA.
DR EMBL; WWCH01000001; MYM77402.1; -; Genomic_DNA.
DR EMBL; JAAGTY010000008; NDW41145.1; -; Genomic_DNA.
DR EMBL; LYKI01000069; OIG67117.1; -; Genomic_DNA.
DR EMBL; NGEL01000141; OTM84511.1; -; Genomic_DNA.
DR EMBL; NGKM01000005; OWK67171.1; -; Genomic_DNA.
DR EMBL; PHJU02000033; PQL81402.1; -; Genomic_DNA.
DR EMBL; NEPB01000037; PRN32691.1; -; Genomic_DNA.
DR EMBL; QKWF01000259; PZM09271.1; -; Genomic_DNA.
DR EMBL; CP035931; QBF38414.1; -; Genomic_DNA.
DR EMBL; CP036283; QBH53190.1; -; Genomic_DNA.
DR EMBL; CP037871; QBM40298.1; -; Genomic_DNA.
DR EMBL; CP037870; QBM42859.1; -; Genomic_DNA.
DR EMBL; CP040084; QCP41638.1; -; Genomic_DNA.
DR EMBL; CP040425; QCT16854.1; -; Genomic_DNA.
DR EMBL; CP044356; QEY03531.1; -; Genomic_DNA.
DR EMBL; CP042556; QFH44962.1; -; Genomic_DNA.
DR EMBL; CP045528; QFX71257.1; -; Genomic_DNA.
DR EMBL; CP033243; QFY69787.1; -; Genomic_DNA.
DR EMBL; CP051875; QJF36271.1; -; Genomic_DNA.
DR EMBL; CP050415; QJG82646.1; -; Genomic_DNA.
DR EMBL; CP062919; QPF14277.1; -; Genomic_DNA.
DR EMBL; RFBY01000003; RSP81077.1; -; Genomic_DNA.
DR EMBL; RFCO01000052; RSQ43240.1; -; Genomic_DNA.
DR EMBL; UFDJ01000015; SSI56624.1; -; Genomic_DNA.
DR EMBL; UFMQ01000002; SST18443.1; -; Genomic_DNA.
DR EMBL; VHEF01000005; TPS31339.1; -; Genomic_DNA.
DR RefSeq; WP_000214787.1; NZ_WYAT01000018.1.
DR STRING; 1096995.BJAB07104_01107; -.
DR GeneID; 66398037; -.
DR KEGG; abw:BL01_14280; -.
DR PATRIC; fig|470.1288.peg.2797; -.
DR eggNOG; COG2224; Bacteria.
DR OMA; WFVYNLS; -.
DR OrthoDB; 8629576at2; -.
DR Proteomes; UP000032746; Chromosome.
DR Proteomes; UP000036348; Chromosome.
DR Proteomes; UP000051023; Unassembled WGS sequence.
DR Proteomes; UP000066661; Chromosome I.
DR Proteomes; UP000070545; Chromosome.
DR Proteomes; UP000072389; Chromosome.
DR Proteomes; UP000179937; Unassembled WGS sequence.
DR Proteomes; UP000192723; Chromosome.
DR Proteomes; UP000194699; Unassembled WGS sequence.
DR Proteomes; UP000197394; Unassembled WGS sequence.
DR Proteomes; UP000229219; Chromosome.
DR Proteomes; UP000233757; Unassembled WGS sequence.
DR Proteomes; UP000236385; Chromosome.
DR Proteomes; UP000237823; Unassembled WGS sequence.
DR Proteomes; UP000248662; Unassembled WGS sequence.
DR Proteomes; UP000249421; Chromosome.
DR Proteomes; UP000252694; Unassembled WGS sequence.
DR Proteomes; UP000257523; Chromosome.
DR Proteomes; UP000262697; Unassembled WGS sequence.
DR Proteomes; UP000268766; Chromosome.
DR Proteomes; UP000269597; Unassembled WGS sequence.
DR Proteomes; UP000270202; Plasmid unnamed1.
DR Proteomes; UP000272401; Unassembled WGS sequence.
DR Proteomes; UP000273577; Chromosome.
DR Proteomes; UP000293712; Chromosome.
DR Proteomes; UP000294205; Chromosome.
DR Proteomes; UP000298622; Chromosome.
DR Proteomes; UP000300722; Chromosome.
DR Proteomes; UP000316901; Unassembled WGS sequence.
DR Proteomes; UP000325982; Chromosome.
DR Proteomes; UP000326895; Chromosome.
DR Proteomes; UP000326952; Chromosome.
DR Proteomes; UP000327158; Chromosome.
DR Proteomes; UP000439424; Unassembled WGS sequence.
DR Proteomes; UP000461234; Unassembled WGS sequence.
DR Proteomes; UP000470018; Unassembled WGS sequence.
DR Proteomes; UP000480763; Unassembled WGS sequence.
DR Proteomes; UP000501210; Chromosome.
DR Proteomes; UP000503033; Chromosome.
DR Proteomes; UP000594659; Chromosome.
DR Proteomes; UP000634608; Unassembled WGS sequence.
DR Proteomes; UP000673677; Unassembled WGS sequence.
DR Proteomes; UP000737470; Unassembled WGS sequence.
DR Proteomes; UP000767556; Unassembled WGS sequence.
DR Proteomes; UP001174156; Unassembled WGS sequence.
DR GO; GO:0004451; F:isocitrate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR CDD; cd00377; ICL_PEPM; 1.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR InterPro; IPR039556; ICL/PEPM.
DR InterPro; IPR006254; Isocitrate_lyase.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR21631:SF3; BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN; 1.
DR PANTHER; PTHR21631; ISOCITRATE LYASE/MALATE SYNTHASE; 1.
DR Pfam; PF00463; ICL; 3.
DR PIRSF; PIRSF001362; Isocit_lyase; 4.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:PZM09271.1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR001362-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR001362-3};
KW Plasmid {ECO:0000313|EMBL:QBF38414.1}.
FT ACT_SITE 222
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001362-1"
FT BINDING 101..103
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT BINDING 184
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR001362-3"
FT BINDING 223..224
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT BINDING 260
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT BINDING 380..384
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT BINDING 451
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
SQ SEQUENCE 534 AA; 59383 MW; F33B637FA54981D9 CRC64;
MTTYQTAIDA VRELKAKFGN TWADISPEDA ARMQLQNRFK TGLDIAKYTA AIMRRDMAEY
DADSSKYTQS LGCWHGFIAQ QKMIANKKYF GTTSKRYIYL SGWMVAALRS EFGPLPDQSM
HEKTSVPALI EEIYTFLRQA DAKELNDLFR ALNKAKEAGD SAKVAEITAQ IDNFETHVVP
IIADIDAGFG NEEATYLLAK KMIEAGACAL QIENQVSDAK QCGHQAGKVT VPHEDFIAKI
HALRYAFLEM GVEDGVIVAR TDSEGADLTQ KIPVVKEPGD IASKYISYLD TQEIDISEAQ
EDEILIKRDG KLHRPTRLAS GLYQFREGTQ IDRVVLDCIT SLQNGADLLW IETPTPNVQE
IAHMVNRVKE VVPNAKLVYN NSPSFNWTLN FRQQAYDRWV AEGKDVSAYD RAKLMSAEYD
NTELAAEADE KIRTFQADAA REAGVFHHLI TLPTYHTAAL STHELAQGYF GDQGMLAYVA
GVQRKEIRGG IACVKHQAMA GSDIGDDHKE IFAGENALKA GDDAKNTMNQ FSAH
//
