ID V5W6Q6_9TELE Unreviewed; 376 AA.
AC V5W6Q6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Growth/differentiation factor 8 {ECO:0000256|ARBA:ARBA00023852, ECO:0000256|RuleBase:RU369049};
DE Short=GDF-8 {ECO:0000256|RuleBase:RU369049};
DE AltName: Full=Myostatin {ECO:0000256|ARBA:ARBA00031866, ECO:0000256|RuleBase:RU369049};
GN Name=MSTN2 {ECO:0000313|EMBL:AHC02688.1};
GN Synonyms=MSTN2 B {ECO:0000313|EMBL:AHC02690.1};
OS Takifugu flavidus (sansaifugu).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=433684 {ECO:0000313|EMBL:AHC02688.1};
RN [1] {ECO:0000313|EMBL:AHC02688.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Z., Zhang G.Y., Shi Y.H., Zhang H.M., Xie Y.D., Zhang Z.H., Lu G.H.,
RA Deng P.P.;
RT "Cloning and characterization of cDNA, poly copies genomic, promoter and 3'
RT flanker of MSTN2 from Takifugu flavidus: evedence for growth and MSTN2.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts specifically as a negative regulator of skeletal muscle
CC growth. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369049}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KF647829; AHC02688.1; -; mRNA.
DR EMBL; KF647831; AHC02690.1; -; Genomic_DNA.
DR AlphaFoldDB; V5W6Q6; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd19388; TGF_beta_GDF8; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF150; GROWTH_DIFFERENTIATION FACTOR 8; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU369049};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU369049};
KW Disulfide bond {ECO:0000256|RuleBase:RU369049};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369049};
KW Signal {ECO:0000256|RuleBase:RU369049, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..376
FT /note="Growth/differentiation factor 8"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007732246"
FT DOMAIN 264..376
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 376 AA; 42615 MW; FA4F611A564CF144 CRC64;
MQLSPSMLHF SLMISLSLVV LSGQETHQQP PVGSPEDTEQ CVTCDVRQHI KTMRLNAIKS
QILSKLRMKE APNISRDTVK QLLPKAPPLQ QLLDQYDVLG DDNRDVVTEE DDEHAITETI
MMMATEPASV VQVNGEPKCC HFSFTQKFQV SRLVRAQLWV HLRPAAEATT VFLQISRLMP
VSDGNRHIRI RSLRLDVKAG ASSWQSIDVK QVLSVWLRQP ETNWGIEINA FDSRGKGLAV
TSTQPGEEGL QPFMEVKISE GPRRVRRDLG LDCDENSPES RCCRYPLTVD FEDFGWDWII
APKRYKANYC SGECEYMHLQ KYPHTHLVNK ANPRGTAGPC CTPTKMSPIN MLYFNQEQQI
IYGKIPSMVV DRCGCL
//
