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Database: UniProt
Entry: V5WCD8_9SPIO
LinkDB: V5WCD8_9SPIO
Original site: V5WCD8_9SPIO 
ID   V5WCD8_9SPIO            Unreviewed;       483 AA.
AC   V5WCD8;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=L21SP2_0001 {ECO:0000313|EMBL:AHC13447.1};
OS   Salinispira pacifica.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Salinispira.
OX   NCBI_TaxID=1307761 {ECO:0000313|EMBL:AHC13447.1, ECO:0000313|Proteomes:UP000018680};
RN   [1] {ECO:0000313|EMBL:AHC13447.1, ECO:0000313|Proteomes:UP000018680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L21-RPul-D2 {ECO:0000313|EMBL:AHC13447.1,
RC   ECO:0000313|Proteomes:UP000018680};
RX   PubMed=26203324; DOI=10.1186/1944-3277-10-7;
RA   Ben Hania W., Joseph M., Schumann P., Bunk B., Fiebig A., Sproer C.,
RA   Klenk H.P., Fardeau M.L., Spring S.;
RT   "Complete genome sequence and description of Salinispira pacifica gen.
RT   nov., sp. nov., a novel spirochaete isolated form a hypersaline
RT   microbial mat.";
RL   Stand. Genomic Sci. 10:7-7(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP006939; AHC13447.1; -; Genomic_DNA.
DR   RefSeq; WP_024266380.1; NC_023035.1.
DR   EnsemblBacteria; AHC13447; AHC13447; L21SP2_0001.
DR   KEGG; slr:L21SP2_0001; -.
DR   PATRIC; fig|1307761.3.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000018680; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018680};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018680}.
FT   DOMAIN      174    306       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      386    455       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     182    189       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   483 AA;  55130 MW;  1C8E754908290310 CRC64;
     MSEWDDYRLF WEEAVKQIQE ELTEQEFSLW FNRMSYASSR QDTIIVSVPS SFYRDQVKSR
     YLSLIENKLY ELSGSRIAIE FQVQAVPSNS APEKNQTRSV SPSSSPRGTS GSQPRSGTQN
     PSAPVARQEP AYRNRSSHHP SLKREYTFDN FIIGENNAFA ANAAMAIAKN PGTGYNPCLV
     YGGVGLGKTH LLQSIGNSVY QDFGDSKIIY VTMENFTNEF IQAIREKKQH MFKNKYRHAD
     VLLIDDIHFL QKKPETQEEL FHTFNALYDS NKQMVFTCDR PVSELKEITD RLRSRFERGL
     NVDLQPPSYE TRYAILKKKI EAAGVQIPEE SINLICENVT TNVRDLEAAL TKLIAYAELV
     NKSITVEITK QQLKDFFSSP IQKNITIAVI QRNVAEYFGV SVQELKSKRK TKTIAFPRQV
     AMYIARDITE YSTTEVGLEF GGRDHTTVMH ACDRIKERMK SDPYLVGQID SLKKAIREAS
     NRA
//
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