ID V5WEN8_9SPIO Unreviewed; 481 AA.
AC V5WEN8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Transporter {ECO:0000313|EMBL:AHC13631.1};
GN ORFNames=L21SP2_0187 {ECO:0000313|EMBL:AHC13631.1};
OS Salinispira pacifica.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Salinispira.
OX NCBI_TaxID=1307761 {ECO:0000313|EMBL:AHC13631.1, ECO:0000313|Proteomes:UP000018680};
RN [1] {ECO:0000313|EMBL:AHC13631.1, ECO:0000313|Proteomes:UP000018680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L21-RPul-D2 {ECO:0000313|EMBL:AHC13631.1,
RC ECO:0000313|Proteomes:UP000018680};
RX PubMed=26203324; DOI=10.1186/1944-3277-10-7;
RA Ben Hania W., Joseph M., Schumann P., Bunk B., Fiebig A., Sproer C.,
RA Klenk H.P., Fardeau M.L., Spring S.;
RT "Complete genome sequence and description of Salinispira pacifica gen.
RT nov., sp. nov., a novel spirochaete isolated form a hypersaline microbial
RT mat.";
RL Stand. Genomic Sci. 10:7-7(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UPF0718 family.
CC {ECO:0000256|ARBA:ARBA00006386}.
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DR EMBL; CP006939; AHC13631.1; -; Genomic_DNA.
DR RefSeq; WP_024266564.1; NC_023035.1.
DR AlphaFoldDB; V5WEN8; -.
DR STRING; 1307761.L21SP2_0187; -.
DR KEGG; slr:L21SP2_0187; -.
DR eggNOG; COG0701; Bacteria.
DR eggNOG; COG2608; Bacteria.
DR HOGENOM; CLU_049002_0_0_12; -.
DR OrthoDB; 9813965at2; -.
DR Proteomes; UP000018680; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR005524; DUF318.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR NCBIfam; NF033936; CuZnOut_SO0444; 1.
DR PANTHER; PTHR34184; UPF0718 PROTEIN YCGR; 1.
DR PANTHER; PTHR34184:SF4; UPF0718 PROTEIN YCGR; 1.
DR Pfam; PF03773; ArsP_1; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 418..481
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 154..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 49715 MW; 14D584A7CE0BBF41 CRC64;
MDSSIFLDIT RIAGDFLNEV ISLFFQMAPY LLLGFTVAGI LSVTLKRSMV ARHVGSPGFS
SVVKAALLGV PLPLCSCAVV PTAGYLRQAG ASKPSLLSFL ISTPQTGVDS VIATYGMMGP
VFAVLRPVIA LFTGIAGGVS SMFFSRSENA AAAEASDGGA ADPGASPAET EEAKEEREAK
EERETEERGK GSEPAAKGLS IPRAAGRAFH YAYIESIDDI ALHFLLGLGV AGLISLLIPD
GFLEGSLIAD GLPGMLLMVL IGIPMYICST SSIPVAVALM AAGISPGAAY VFLVAGPATN
AATLAVLKRM LGFRSVLLYL GTIIIGALLF GPLVNLVFAA GGWEPVLSSA AGEAHGNGLL
EYISGGALAL MIGAFFYRTL RSRLGRRNTG PGNGAENTSQ ADRIVAGDGP DSREDGGFRI
SMNIEGMTCA HCASTVRQAL ESVEGTRSVS VDLKNGTARV HGHADENALA SAVKAQGYLV
K
//
