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Database: UniProt
Entry: V5X713_MYCNE
LinkDB: V5X713_MYCNE
Original site: V5X713_MYCNE 
ID   V5X713_MYCNE            Unreviewed;       495 AA.
AC   V5X713;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   05-JUL-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=D174_02180 {ECO:0000313|EMBL:AHC23471.1};
OS   Mycobacterium neoaurum VKM Ac-1815D.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=700508 {ECO:0000313|EMBL:AHC23471.1, ECO:0000313|Proteomes:UP000018763};
RN   [1] {ECO:0000313|EMBL:AHC23471.1, ECO:0000313|Proteomes:UP000018763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-1815D {ECO:0000313|EMBL:AHC23471.1};
RX   PubMed=24435872;
RA   Shtratnikova V.Y., Bragin E.Y., Dovbnya D.V., Pekov Y.A.,
RA   Schelkunov M.I., Strizhov N., Ivashina T.V., Ashapkin V.V.,
RA   Donova M.V.;
RT   "Complete Genome Sequence of Sterol-Transforming Mycobacterium
RT   neoaurum Strain VKM Ac-1815D.";
RL   Genome Announc. 2:e01177-13(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP006936; AHC23471.1; -; Genomic_DNA.
DR   RefSeq; WP_023985097.1; NC_023036.2.
DR   EnsemblBacteria; AHC23471; AHC23471; D174_02180.
DR   KEGG; mne:D174_02180; -.
DR   KO; K02313; -.
DR   Proteomes; UP000018763; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018763};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018763}.
FT   DOMAIN      188    316       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      400    468       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     196    203       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   495 AA;  55687 MW;  961D98E282A8D1F7 CRC64;
     MTADPDSSFV TVWNNVVAEL NGETPFGETV NGGPRESTLT AQQRAWLKLV RPLVITEGFA
     LLSVPTAFVQ NEIERGLREP IIEALSRQLG QRVELGVRIA TPPPDDDTDT EPPQDSADTE
     EVDDDLAAIE SAEASWPTFF NRSQTPAPEA ANSVTLNRRY TFETFVIGSS NRFAHAATLA
     ISEAPARAYN PLFIWGESGL GKTHLLHAAG NYAQRLFPGM RVKYVSTEEF TNDFINSLRD
     DRKASFKRSY RDVDILLVDD IQFIEGKDGI QEEFFHTFNT LHNANKQIVI SSDRSPKQLA
     TLEDRLRTRF EWGLITDVQP PELETRIAIL RKKAQMDRLD VPDDVLELIA SRIERNIREL
     EGALIRVTAF ASLSKTTIDK SLAEIVLRDL IADAGTMQIS TATIMAATAE YFETSVEELR
     GPGKTRALAQ ARQIAMYLCR ELTDLSLPRI GEAFGRDHTT VMYAERKIRD GMAERREIFD
     HVKELTTRIR QRSKR
//
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