ID V5YJ01_9HIV1 Unreviewed; 288 AA.
AC V5YJ01;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Integrase {ECO:0000313|EMBL:BAO17435.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:BAO17435.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:BAO17435.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:BAO17435.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E12-50911243-1 {ECO:0000313|EMBL:BAO17435.1};
RX PubMed=17194486; DOI=10.1016/j.antiviral.2006.11.012;
RA Gatanaga H., Ibe S., Matsuda M., Yoshida S., Asagi T., Kondo M.,
RA Sadamasu K., Tsukada H., Masakane A., Mori H., Takata N., Minami R.,
RA Tateyama M., Koike T., Itoh T., Imai M., Nagashima M., Gejyo F., Ueda M.,
RA Hamaguchi M., Kojima Y., Shirasaka T., Kimura A., Yamamoto M., Fujita J.,
RA Oka S., Sugiura W.;
RT "Drug-resistant HIV-1 prevalence in patients newly diagnosed with HIV/AIDS
RT in Japan.";
RL Antiviral Res. 75:75-82(2007).
RN [2] {ECO:0000313|EMBL:BAO17435.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E12-50911243-1 {ECO:0000313|EMBL:BAO17435.1};
RX PubMed=20692295; DOI=10.1016/j.antiviral.2010.07.008;
RA Hattori J., Shiino T., Gatanaga H., Yoshida S., Watanabe D., Minami R.,
RA Sadamasu K., Kondo M., Mori H., Ueda M., Tateyama M., Ueda A., Kato S.,
RA Itoh T., Oie M., Takata N., Hayashida T., Nagashima M., Matsuda M., Ibe S.,
RA Ota Y., Sasaki S., Ishigatsubo Y., Tanabe Y., Koga I., Kojima Y.,
RA Yamamoto M., Fujita J., Yokomaku Y., Koike T., Shirasaka T., Oka S.,
RA Sugiura W.;
RT "Trends in transmitted drug-resistant HIV-1 and demographic characteristics
RT of newly diagnosed patients: nationwide surveillance from 2003 to 2008 in
RT Japan.";
RL Antiviral Res. 88:72-79(2010).
RN [3] {ECO:0000313|EMBL:BAO17435.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E12-50911243-1 {ECO:0000313|EMBL:BAO17435.1};
RX PubMed=25025900; DOI=10.1371/journal.pone.0102633;
RG Japanese Drug Resistance HIV-1 Surveillance Network;
RA Shiino T., Hattori J., Yokomaku Y., Iwatani Y., Sugiura W.;
RT "Phylodynamic Analysis Reveals CRF01_AE Dissemination between Japan and
RT Neighboring Asian Countries and the Role of Intravenous Drug Use in
RT Transmission.";
RL PLoS ONE 9:e102633-e102633(2014).
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DR EMBL; AB870367; BAO17435.1; -; Genomic_RNA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 3..44
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 54..204
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 223..270
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 223..270
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAO17435.1"
FT NON_TER 288
FT /evidence="ECO:0000313|EMBL:BAO17435.1"
SQ SEQUENCE 288 AA; 32212 MW; 7380CE76F29B2491 CRC64;
FLDGIDKAQE EHEKYHNNWR AMASDFNIPP VVAKEIVASC DKCQQKGEAM HGQVDCSPGI
WQLDCTHLEG KIILVAVHVA SGYIEAEVIP AETGQETAYF LLKLAGRWPV KTVHTDNGSN
FTSNAVKAAC WWAGIKQEFG IPYNPQSQGV VESMNKELKK IIEQVRDQAE HLKTAVQMAV
FIHNFKRKGG IGGYSAGERI VDIIATDIQT KELQKNITKI QNFRVXYRDS RDPXWKGPAK
LLWKGEGAVV IQDNGDIKVV PRRKAKIIRD YGKQMAGDDC VASRQDED
//
