ID V5YJH2_9HIV1 Unreviewed; 288 AA.
AC V5YJH2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Integrase {ECO:0000313|EMBL:BAO17448.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:BAO17448.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:BAO17448.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:BAO17448.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E12-50911262-1 {ECO:0000313|EMBL:BAO17448.1};
RX PubMed=17194486; DOI=10.1016/j.antiviral.2006.11.012;
RA Gatanaga H., Ibe S., Matsuda M., Yoshida S., Asagi T., Kondo M.,
RA Sadamasu K., Tsukada H., Masakane A., Mori H., Takata N., Minami R.,
RA Tateyama M., Koike T., Itoh T., Imai M., Nagashima M., Gejyo F., Ueda M.,
RA Hamaguchi M., Kojima Y., Shirasaka T., Kimura A., Yamamoto M., Fujita J.,
RA Oka S., Sugiura W.;
RT "Drug-resistant HIV-1 prevalence in patients newly diagnosed with HIV/AIDS
RT in Japan.";
RL Antiviral Res. 75:75-82(2007).
RN [2] {ECO:0000313|EMBL:BAO17448.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E12-50911262-1 {ECO:0000313|EMBL:BAO17448.1};
RX PubMed=20692295; DOI=10.1016/j.antiviral.2010.07.008;
RA Hattori J., Shiino T., Gatanaga H., Yoshida S., Watanabe D., Minami R.,
RA Sadamasu K., Kondo M., Mori H., Ueda M., Tateyama M., Ueda A., Kato S.,
RA Itoh T., Oie M., Takata N., Hayashida T., Nagashima M., Matsuda M., Ibe S.,
RA Ota Y., Sasaki S., Ishigatsubo Y., Tanabe Y., Koga I., Kojima Y.,
RA Yamamoto M., Fujita J., Yokomaku Y., Koike T., Shirasaka T., Oka S.,
RA Sugiura W.;
RT "Trends in transmitted drug-resistant HIV-1 and demographic characteristics
RT of newly diagnosed patients: nationwide surveillance from 2003 to 2008 in
RT Japan.";
RL Antiviral Res. 88:72-79(2010).
RN [3] {ECO:0000313|EMBL:BAO17448.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E12-50911262-1 {ECO:0000313|EMBL:BAO17448.1};
RX PubMed=25025900; DOI=10.1371/journal.pone.0102633;
RG Japanese Drug Resistance HIV-1 Surveillance Network;
RA Shiino T., Hattori J., Yokomaku Y., Iwatani Y., Sugiura W.;
RT "Phylodynamic Analysis Reveals CRF01_AE Dissemination between Japan and
RT Neighboring Asian Countries and the Role of Intravenous Drug Use in
RT Transmission.";
RL PLoS ONE 9:e102633-e102633(2014).
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DR EMBL; AB870380; BAO17448.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 3..44
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 54..204
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 223..270
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 223..270
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAO17448.1"
FT NON_TER 288
FT /evidence="ECO:0000313|EMBL:BAO17448.1"
SQ SEQUENCE 288 AA; 32319 MW; 3D57500B8E9073C4 CRC64;
FLDGIDKAQE EHERYHSNWR TMASDFNLPP IVAKEIVANC DKCQLKGEAM HGQVDCSPGI
WQLDCTHLEG KVILVAVHVA SGYIEAEVIP AETGQETAYF LLKLAGRWPV KVIHTDNGSN
FTSAAVKAAC WWANVRQEFG IPYNPQSQGV VESMNKELKK IIGQVREQAE HLKTAVQMAV
FIHNFKRKGG IGGYSAGERI IDIIATDIQT KELQKQITKI QNFRVYYRDS RDPIWKGPAK
LLWKGEGAVV IQDNSDIKVV PRRKAKIIRD YGKQMAGDDC VAGRQDED
//