GenomeNet

Database: UniProt
Entry: V5YJI4_9HIV1
LinkDB: V5YJI4_9HIV1
Original site: V5YJI4_9HIV1 
ID   V5YJI4_9HIV1            Unreviewed;       288 AA.
AC   V5YJI4;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Integrase {ECO:0000313|EMBL:BAO17463.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:BAO17463.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:BAO17463.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:BAO17463.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E12-50911271-1 {ECO:0000313|EMBL:BAO17463.1};
RX   PubMed=17194486; DOI=10.1016/j.antiviral.2006.11.012;
RA   Gatanaga H., Ibe S., Matsuda M., Yoshida S., Asagi T., Kondo M.,
RA   Sadamasu K., Tsukada H., Masakane A., Mori H., Takata N., Minami R.,
RA   Tateyama M., Koike T., Itoh T., Imai M., Nagashima M., Gejyo F., Ueda M.,
RA   Hamaguchi M., Kojima Y., Shirasaka T., Kimura A., Yamamoto M., Fujita J.,
RA   Oka S., Sugiura W.;
RT   "Drug-resistant HIV-1 prevalence in patients newly diagnosed with HIV/AIDS
RT   in Japan.";
RL   Antiviral Res. 75:75-82(2007).
RN   [2] {ECO:0000313|EMBL:BAO17463.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E12-50911271-1 {ECO:0000313|EMBL:BAO17463.1};
RX   PubMed=20692295; DOI=10.1016/j.antiviral.2010.07.008;
RA   Hattori J., Shiino T., Gatanaga H., Yoshida S., Watanabe D., Minami R.,
RA   Sadamasu K., Kondo M., Mori H., Ueda M., Tateyama M., Ueda A., Kato S.,
RA   Itoh T., Oie M., Takata N., Hayashida T., Nagashima M., Matsuda M., Ibe S.,
RA   Ota Y., Sasaki S., Ishigatsubo Y., Tanabe Y., Koga I., Kojima Y.,
RA   Yamamoto M., Fujita J., Yokomaku Y., Koike T., Shirasaka T., Oka S.,
RA   Sugiura W.;
RT   "Trends in transmitted drug-resistant HIV-1 and demographic characteristics
RT   of newly diagnosed patients: nationwide surveillance from 2003 to 2008 in
RT   Japan.";
RL   Antiviral Res. 88:72-79(2010).
RN   [3] {ECO:0000313|EMBL:BAO17463.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E12-50911271-1 {ECO:0000313|EMBL:BAO17463.1};
RX   PubMed=25025900; DOI=10.1371/journal.pone.0102633;
RG   Japanese Drug Resistance HIV-1 Surveillance Network;
RA   Shiino T., Hattori J., Yokomaku Y., Iwatani Y., Sugiura W.;
RT   "Phylodynamic Analysis Reveals CRF01_AE Dissemination between Japan and
RT   Neighboring Asian Countries and the Role of Intravenous Drug Use in
RT   Transmission.";
RL   PLoS ONE 9:e102633-e102633(2014).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB870395; BAO17463.1; -; Genomic_RNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR   InterPro; IPR001037; Integrase_C_retrovir.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR   Pfam; PF00552; IN_DBD_C; 1.
DR   Pfam; PF02022; Integrase_Zn; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR   SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS51027; INTEGRASE_DBD; 1.
DR   PROSITE; PS50876; ZF_INTEGRASE; 1.
PE   4: Predicted;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00450}.
FT   DOMAIN          3..44
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50876"
FT   DOMAIN          54..204
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51027"
FT   DNA_BIND        223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT   UNSURE          101
FT                   /note="I or L"
FT                   /evidence="ECO:0000313|EMBL:BAO17463.1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAO17463.1"
FT   NON_TER         288
FT                   /evidence="ECO:0000313|EMBL:BAO17463.1"
SQ   SEQUENCE   288 AA;  32321 MW;  EA5B531B259B26E4 CRC64;
     FLDGIDKAQE EHERYHSNWR AMASDFXIPP VVAKEIVACC DKCQLKGEAM HGQVDCNPGI
     WQLDCTHLEG KIILVAVHVA SGYMEAEVIP AETGQETAYF LLKLAGRWPV KTIHTDNGTN
     FTSXTVKAAC WWAGIKQEFG IPYNPQSQGV VESMNKELKX IIGQVRDQAE HLKTAVQMAV
     FIHNFKRKGG IGGYSAGERI IDIIASDIQT KELQKQITKI QNFRVYYRDS RDPLWKGPAK
     LLWKGEGAVV IQDNSDIKVV PRRKAKIIRD YGKQMAGDDC VASRQDED
//
DBGET integrated database retrieval system