UniProt: V5YUX7

Database: UniProt
Entry: V5YUX7_SERMA

LinkDB:  V5YUX7_SERMA 
Original site:  V5YUX7_SERMA

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Ontology (4)   
   GO (4)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (14)   
   EMBL (14)   
Protein domain (6)   
   InterPro (4)   
   Pfam (1)   
   PROSITE (1)   
Literature (3)   
   PubMed (3)   
All databases (29)   

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ID   V5YUX7_SERMA            Unreviewed;       196 AA.
AC   V5YUX7; A0A3E2ED57; A0A656VFI1;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=DnaA initiator-associating protein DiaA {ECO:0000256|HAMAP-Rule:MF_01157};
GN   Name=diaA {ECO:0000256|HAMAP-Rule:MF_01157,
GN   ECO:0000313|EMBL:BAO21049.1};
GN   ORFNames=AB868_04557 {ECO:0000313|EMBL:KMU50610.1}, AN695_0218405
GN   {ECO:0000313|EMBL:OCO84030.1}, AR325_24730
GN   {ECO:0000313|EMBL:ALL40006.1}, BHU62_10505
GN   {ECO:0000313|EMBL:OKB66659.1}, BVG93_18860
GN   {ECO:0000313|EMBL:ASM13866.1}, BVG97_19320
GN   {ECO:0000313|EMBL:ASL89614.1}, CHR63_10495
GN   {ECO:0000313|EMBL:OYO98544.1}, DKC05_18125
GN   {ECO:0000313|EMBL:AWL69429.1}, DMW43_16415
GN   {ECO:0000313|EMBL:PYA04234.1}, FHU12_5069
GN   {ECO:0000313|EMBL:TQI87377.1}, FOT62_01370
GN   {ECO:0000313|EMBL:TXE37377.1}, HP475_24325
GN   {ECO:0000313|EMBL:QLJ62835.1}, NCTC10211_01759
GN   {ECO:0000313|EMBL:SUI44699.1};
OS   Serratia marcescens.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615 {ECO:0000313|EMBL:BAO21049.1};
RN   [1] {ECO:0000313|EMBL:QLJ62835.1, ECO:0000313|Proteomes:UP000510935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12/2010 {ECO:0000313|EMBL:QLJ62835.1,
RC   ECO:0000313|Proteomes:UP000510935};
RX   PubMed=21967170;
RA   Greco-Stewart V.S., Brown E.E., Parr C., Kalab M., Jacobs M.R.,
RA   Yomtovian R.A., Ramirez-Arcos S.M.;
RT   "Serratia marcescens strains implicated in adverse transfusion reactions
RT   form biofilms in platelet concentrates and demonstrate reduced detection by
RT   automated culture.";
RL   Vox Sang. 102:212-220(2012).
RN   [2] {ECO:0000313|EMBL:BAO21049.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IOMTU 115 {ECO:0000313|EMBL:BAO21049.1};
RA   Tada T., Miyoshi-Akiyama T., Kirikae T.;
RT   "Genetic environments surrounding aac(6')-Ial.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KMU50610.1, ECO:0000313|Proteomes:UP000037482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AH0650_Sm1 {ECO:0000313|EMBL:KMU50610.1,
RC   ECO:0000313|Proteomes:UP000037482};
RA   Wan Y., Gorrie C., Holt K.;
RT   "Draft Genome of Serratia marcescens Strain AH0650_Sm1.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000058492}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B3R3 {ECO:0000313|Proteomes:UP000058492};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000050489}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=945174350 {ECO:0000313|Proteomes:UP000050489};
RA   Osei Sekyere J., Sivertsen A., Pedersen A.T., Sundsfjord A.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:OKB66659.1, ECO:0000313|Proteomes:UP000185770}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSU-97 {ECO:0000313|EMBL:OKB66659.1,
RC   ECO:0000313|Proteomes:UP000185770};
RA   Matilla M.A.;
RT   "Serratia marcescens MSU-97 and epiphytic antimycotic-producing bacteria.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000198289, ECO:0000313|Proteomes:UP000198428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMH5 {ECO:0000313|EMBL:ASL89614.1,
RC   ECO:0000313|Proteomes:UP000198428}, and UMH6
RC   {ECO:0000313|EMBL:ASM13866.1, ECO:0000313|Proteomes:UP000198289};
RX   PubMed=28536292;
RA   Anderson M.T., Mitchell L.A., Zhao L., Mobley H.L.T.;
RT   "Capsule Production and Glucose Metabolism Dictate Fitness during Serratia
RT   marcescens Bacteremia.";
RL   MBio 8:e00740-e00717(2017).
RN   [8] {ECO:0000313|EMBL:OCO84030.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=945174350 {ECO:0000313|EMBL:OCO84030.1};
RX   PubMed=28636609;
RA   Osei Sekyere J., Amoako D.G.;
RT   "Genomic and phenotypic characterisation of fluoroquinolone resistance
RT   mechanisms in Enterobacteriaceae in Durban, South Africa.";
RL   PLoS ONE 12:E0178888-E0178888(2017).
RN   [9] {ECO:0000313|EMBL:ALL40006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B3R3 {ECO:0000313|EMBL:ALL40006.1};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:OYO98544.1, ECO:0000313|Proteomes:UP000215604}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=at10508 {ECO:0000313|Proteomes:UP000215604}, and At10508
RC   {ECO:0000313|EMBL:OYO98544.1};
RA   Lepuschitz S., Sorschag S., Springer B., Allerberger F., Ruppitsch W.;
RT   "Draft Genome of a clinical carbapenemase producing Serratia marcescens
RT   isolate.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AWL69429.1, ECO:0000313|Proteomes:UP000245399}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAV1761 {ECO:0000313|EMBL:AWL69429.1,
RC   ECO:0000313|Proteomes:UP000245399};
RA   Mathers A.J., Vegesana K., Stoesser N., Crook D., Vaughan A., Barry K.,
RA   Parikh H., Sebra R., Kotay S., Walker A.S., Sheppard A.E.;
RT   "Klebsiella quasipneumonaiae provides a window into carbapenemase gene
RT   transfer, plasmid rearrangements and nosocomial acquisition from the
RT   hospital environment.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:PYA04234.1, ECO:0000313|Proteomes:UP000248086}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1058 {ECO:0000313|EMBL:PYA04234.1,
RC   ECO:0000313|Proteomes:UP000248086};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Serratia marcescens genome sequencing and assembly.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:SUI44699.1, ECO:0000313|Proteomes:UP000254765}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10211 {ECO:0000313|EMBL:SUI44699.1,
RC   ECO:0000313|Proteomes:UP000254765};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:PYA04234.1, ECO:0000313|Proteomes:UP000248086}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1058 {ECO:0000313|EMBL:PYA04234.1,
RC   ECO:0000313|Proteomes:UP000248086};
RA   Zhirakovskaya E.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:TQI87377.1, ECO:0000313|Proteomes:UP000320710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=106R {ECO:0000313|EMBL:TQI87377.1,
RC   ECO:0000313|Proteomes:UP000320710};
RA   Deangelis K., Huntemann M., Clum A., Pillay M., Palaniappan K.,
RA   Varghese N., Mikhailova N., Stamatis D., Reddy T., Daum C., Shapiro N.,
RA   Ivanova N., Kyrpides N., Woyke T.;
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:TQI87377.1, ECO:0000313|Proteomes:UP000320710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=106R {ECO:0000313|EMBL:TQI87377.1,
RC   ECO:0000313|Proteomes:UP000320710};
RA   Deangelis K.PhD.;
RT   "Investigation of anaerobic lignin degradation for improved lignocellulosic
RT   biofuels.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:TXE37377.1, ECO:0000313|Proteomes:UP000321126}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S16 {ECO:0000313|EMBL:TXE37377.1,
RC   ECO:0000313|Proteomes:UP000321126};
RA   Cho G.-S., Stein M., Lee W., Suh S.H., Franz C.M.A.P.;
RT   "Serratia strains were isolated from fresh produce.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:QLJ62835.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=12/2010 {ECO:0000313|EMBL:QLJ62835.1};
RA   Diamandas A., Razon M., Sykes E., Ramirez-Arcos S., Brassinga A.K.C.;
RL   Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the timely initiation of chromosomal replication
CC       via direct interactions with the DnaA initiator protein.
CC       {ECO:0000256|HAMAP-Rule:MF_01157}.
CC   -!- SUBUNIT: Homotetramer; dimer of dimers. {ECO:0000256|HAMAP-
CC       Rule:MF_01157}.
CC   -!- SIMILARITY: Belongs to the SIS family. DiaA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01157}.
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DR   EMBL; CP013046; ALL40006.1; -; Genomic_DNA.
DR   EMBL; CP018917; ASL89614.1; -; Genomic_DNA.
DR   EMBL; CP018926; ASM13866.1; -; Genomic_DNA.
DR   EMBL; CP029449; AWL69429.1; -; Genomic_DNA.
DR   EMBL; AB894481; BAO21049.1; -; Genomic_DNA.
DR   EMBL; LFJS01000014; KMU50610.1; -; Genomic_DNA.
DR   EMBL; LJEX02000101; OCO84030.1; -; Genomic_DNA.
DR   EMBL; MJAO01000009; OKB66659.1; -; Genomic_DNA.
DR   EMBL; NPIX01000009; OYO98544.1; -; Genomic_DNA.
DR   EMBL; QJPU01000009; PYA04234.1; -; Genomic_DNA.
DR   EMBL; CP053925; QLJ62835.1; -; Genomic_DNA.
DR   EMBL; UGYK01000002; SUI44699.1; -; Genomic_DNA.
DR   EMBL; VFMJ01000001; TQI87377.1; -; Genomic_DNA.
DR   EMBL; VOUQ01000001; TXE37377.1; -; Genomic_DNA.
DR   RefSeq; WP_004937103.1; NZ_WVHX01000009.1.
DR   STRING; 273526.SMDB11_3573; -.
DR   GeneID; 79509356; -.
DR   PATRIC; fig|615.101.peg.2228; -.
DR   OrthoDB; 9810929at2; -.
DR   Proteomes; UP000037482; Unassembled WGS sequence.
DR   Proteomes; UP000050489; Unassembled WGS sequence.
DR   Proteomes; UP000058492; Chromosome.
DR   Proteomes; UP000185770; Unassembled WGS sequence.
DR   Proteomes; UP000198289; Chromosome.
DR   Proteomes; UP000198428; Chromosome.
DR   Proteomes; UP000215604; Unassembled WGS sequence.
DR   Proteomes; UP000245399; Chromosome.
DR   Proteomes; UP000248086; Unassembled WGS sequence.
DR   Proteomes; UP000254765; Unassembled WGS sequence.
DR   Proteomes; UP000320710; Unassembled WGS sequence.
DR   Proteomes; UP000321126; Unassembled WGS sequence.
DR   Proteomes; UP000510935; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd05006; SIS_GmhA; 1.
DR   HAMAP; MF_01157; SIS_DiaA; 1.
DR   InterPro; IPR023070; DiaA.
DR   InterPro; IPR035461; GmhA/DiaA.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   PANTHER; PTHR30390:SF6; DNAA INITIATOR-ASSOCIATING PROTEIN DIAA; 1.
DR   PANTHER; PTHR30390; SEDOHEPTULOSE 7-PHOSPHATE ISOMERASE / DNAA INITIATOR-ASSOCIATING FACTOR FOR REPLICATION INITIATION; 1.
DR   Pfam; PF13580; SIS_2; 1.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS51464; SIS; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_01157}; Isomerase {ECO:0000313|EMBL:ALL40006.1}.
FT   DOMAIN          34..196
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
SQ   SEQUENCE   196 AA;  21168 MW;  93DB4F19EF1C6FAE CRC64;
     MLDRIKVCFT ESIQTQIAAA EALPDAISRA AMTLVQSLLN GNKILCCGNG TSAANAQHFA
     ASMINRFETE RPSLPAIALN ADNVVLTAIS NDRLHDEVYA KQVRALGHTG DVLLAISTRG
     NSRDIVKAVE AAVTRDMTIV ALTGYDGGEL AGLLGQQDVE IRIPSHRSSR IQEMHMLTVN
     CLCDLIDNTL FPHQDD
//

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