ID V6CIX1_CAEEL Unreviewed; 779 AA.
AC V6CIX1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Helicase ATP-binding domain-containing protein {ECO:0000313|EMBL:CDK13387.1};
GN Name=drh-1 {ECO:0000313|EMBL:CDK13387.1,
GN ECO:0000313|WormBase:F15B10.2b};
GN ORFNames=CELE_F15B10.2 {ECO:0000313|EMBL:CDK13387.1}, F15B10.2
GN {ECO:0000313|WormBase:F15B10.2b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CDK13387.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CDK13387.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CDK13387.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00029316};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00029316};
CC -!- SIMILARITY: Belongs to the helicase family. RLR subfamily.
CC {ECO:0000256|ARBA:ARBA00006866}.
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DR EMBL; BX284604; CDK13387.1; -; Genomic_DNA.
DR RefSeq; NP_001293710.1; NM_001306781.1.
DR AlphaFoldDB; V6CIX1; -.
DR SMR; V6CIX1; -.
DR PeptideAtlas; V6CIX1; -.
DR EnsemblMetazoa; F15B10.2b.1; F15B10.2b.1; WBGene00001090.
DR AGR; WB:WBGene00001090; -.
DR WormBase; F15B10.2b; CE49130; WBGene00001090; drh-1.
DR GeneTree; ENSGT00940000153173; -.
DR HOGENOM; CLU_006888_2_1_1; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00001090; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; V6CIX1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1320.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.170.150.30; RIG-I-like receptor, C-terminal regulatory domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038557; RLR_C_sf.
DR InterPro; IPR021673; RLR_CTR.
DR PANTHER; PTHR14074:SF29; DICER-RELATED HELICASE; 1.
DR PANTHER; PTHR14074; HELICASE WITH DEATH DOMAIN-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF11648; RIG-I_C-RD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51789; RLR_CTR; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CDK13387.1};
KW Helicase {ECO:0000313|EMBL:CDK13387.1};
KW Hydrolase {ECO:0000313|EMBL:CDK13387.1};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|EPD:V6CIX1,
KW ECO:0007829|PeptideAtlas:V6CIX1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 43..233
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 424..597
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 619..748
FT /note="RLR CTR"
FT /evidence="ECO:0000259|PROSITE:PS51789"
SQ SEQUENCE 779 AA; 88978 MW; 5ED9614A0CB49BA0 CRC64;
MINIRVDNIV QENSTPRLVI ESVRQRIHRQ RQLCLRNYQE ELCQVALQGK NTIVTAPTGS
GKTVIAANII KEHFESRSSE GKRFKALFMT PNSMILNQQA ASISSYLDHV YHTQIIQGSD
NVPTRNVIQS KDLIVATPQM IVNLCNEHRN SLDDESRLDQ FFLSTFTIIF FDECHNTVKN
SPYSNIMREY HYLKNMGNMP EGHSLPQIIG LTASLGTGDK NDCLQVRNYI AGLCASMDVK
DLSIVKDNLE ELRGYSPIVP DKVLLCERST DGPIGMFTNR LTLMMQEVEG LIRTALRNEH
IGIEQRRQIE TTERDFRPDS SFLDPPADKE HAGYQNWVCN QMNLVSGTSF RETGTRTIIN
EALDVLKECF CTLSYNINFH PEVALNYLKD EMEYRTPNFT VNMIRIWERY HNQLVGTGSA
ENPMISKTVQ YIVEQNLQRA DSRTIIFVRT RYEATILNKV LNSNEELLML GIKSEWMSGL
NKSTASSADI SASKQKQMEK LKMFADGEIR ILVSTSVAEE GLDVPECSLV IKYNYATNEI
AHVQRRGRGR ALNSECVLIT NSIALRDQES NNRDKESLMS ETISLIQNSP AEFRKCVDEE
SNKIWPRILR EDTDKAQKIE EQINRNIVYK IICKKCEAIL CTSKDIRSRN TQYLVCDPGF
WSLVRKTRLT DEQQALIKYN ATGSINCRRE NCGLKLGQLI EVNTVDLPCL SALSIVLLVE
GTDKRIIVKK WKNILDKYFT PTEIRQLDVQ TMRDADQART PMVFEHHANG EVVNLIREA
//
