ID V6JLG8_STRRC Unreviewed; 340 AA.
AC V6JLG8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:EST20720.1};
GN ORFNames=M878_38845 {ECO:0000313|EMBL:EST20720.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST20720.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST20720.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST20720.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST20720.1}.
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DR EMBL; AWQX01000344; EST20720.1; -; Genomic_DNA.
DR AlphaFoldDB; V6JLG8; -.
DR STRING; 1352936.M878_38845; -.
DR PATRIC; fig|1352936.5.peg.8044; -.
DR HOGENOM; CLU_034992_0_0_11; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF99; 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000017984}.
FT DOMAIN 27..183
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 198..328
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 124
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 340 AA; 37287 MW; 9454820DE31A169F CRC64;
MITMEETLEL ARSRHADHPQ LPLALRLIEN TGVRTRHIVQ PIEETLKHPG FEERNKLYEA
EAKARVPAVI QRALDDAELL TTDIDMIIYV SCTGFMMPSL TAWLINEMDF DPTTRQFPIA
QLGCAAGGAA INRAHDFCTA YPEANALIVA CEFCSLCYQP TDLGVGSLLS NGLFGDGIAA
AVVRGIGGTG IELERNGSYL IPKTEEWIMY DVRATGFHFL LDKRVPATME PLAPALQDLA
GTHGWDASDL DFYIVHAGGP RILDDLSKFL QVDPHAFRFS RATLTEYGNI ASGVVLDALR
RMFDEGGAEH RARGLLAGFG PGITAEMALG RWRSPDRETA
//
