ID V6JLS4_STRRC Unreviewed; 338 AA.
AC V6JLS4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein {ECO:0000259|Pfam:PF02826};
GN ORFNames=M878_40305 {ECO:0000313|EMBL:EST20056.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST20056.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST20056.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST20056.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST20056.1}.
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DR EMBL; AWQX01000360; EST20056.1; -; Genomic_DNA.
DR AlphaFoldDB; V6JLS4; -.
DR STRING; 1352936.M878_40305; -.
DR PATRIC; fig|1352936.5.peg.8345; -.
DR HOGENOM; CLU_019796_1_3_11; -.
DR OrthoDB; 4324715at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12167; 2-Hacid_dh_8; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017984}.
FT DOMAIN 125..298
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 338 AA; 35584 MW; A2C532B2ADA14A08 CRC64;
MAARPDRPDL PVAVCVMDPS IVGQVLPAEL RERLSARVRL APVQEGSAPR AMFPAEFAEA
EILISGWGCP RLTPDVLAGA PRLRAVMHAA GTVKSLVSDA VWERGIVVSS AADANAGPVV
AYTLALIALA TRRTLTMAAR YEDGWPASEY RSGADGSTVG IVGASRIGRG VLAALRRSDA
GHRLLLTDPY VTDDETRRLG AERVELAELC RRSAVVSVHA PLLPETTGLL DAAMLGLIPD
GGVLINTARG AIVDTEALTH ECASGRLEAY LDVTDPEPLP PGHPLLSLPN VLVTPHIAGA
QGSEVQRLGR YAVAEVDRWV TGEPLLGAVT REALSHLA
//
