ID V6K516_STRRC Unreviewed; 406 AA.
AC V6K516;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=M878_25030 {ECO:0000313|EMBL:EST27265.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST27265.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST27265.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST27265.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST27265.1}.
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DR EMBL; AWQX01000214; EST27265.1; -; Genomic_DNA.
DR RefSeq; WP_023549569.1; NZ_CM002285.1.
DR AlphaFoldDB; V6K516; -.
DR STRING; 1352936.M878_25030; -.
DR PATRIC; fig|1352936.5.peg.5217; -.
DR HOGENOM; CLU_000022_69_2_11; -.
DR OrthoDB; 416758at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR CDD; cd00832; CLF; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF322; POLYKETIDE BETA-KETOACYL SYNTHASE 2-RELATED; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000017984};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 2..404
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 406 AA; 41734 MW; EC77466108FB78FE CRC64;
MTTSTVVTGL GIAAPNGLGT EDYWKATLAG ESGIGPVTRF DATRYPARLA GEVPGFVAEE
HIPSRLMPQT DHMTRLALAA AEWALQDAGL DTGEVPEYGM GVVTSASGGA VEFGQRELQN
LWSKGKEHVS AYQSFAWFYA VNTGQISIRH KLRGPSGVLL TEQAGGIDAI GQARRHVRKG
FQAVVSGGVD AGICPWGWVP QLTTGLMSTE QDPARAYLPF AAEASGYVVG EGGAILVAED
LAAARERGAS HVYGEIAGYA ATLDPDPGSG RPPGLARAVR TALTDAGLTP AGIDVVFADA
AGVPELDRAE AEVLAEVFGP NAVPVTAPKS MTGRLLAGGA ALDAATALLA LRDGVIPHTA
GVDAAAADYP IDLVTGAPRE ADLRSALVLA RGHGGFNAAL VVRRAA
//
