ID   V6KGP0_9ACTN            Unreviewed;       534 AA.
AC   V6KGP0;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Choline transporter {ECO:0008006|Google:ProtNLM};
GN   ORFNames=N566_20725 {ECO:0000313|EMBL:EST31232.1};
OS   Streptomycetaceae bacterium MP113-05.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae.
OX   NCBI_TaxID=1380770 {ECO:0000313|EMBL:EST31232.1, ECO:0000313|Proteomes:UP000017915};
RN   [1] {ECO:0000313|EMBL:EST31232.1, ECO:0000313|Proteomes:UP000017915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP113-05 {ECO:0000313|EMBL:EST31232.1,
RC   ECO:0000313|Proteomes:UP000017915};
RA   Valde M., Degnes K.F., Sletta H., Ruckert C., Kalinowski J., Zotchev S.B.;
RT   "Streptomyces bacterium from a marine sponge: physiological
RT   characterization and genome-based analysis of secondary metabolite
RT   biosynthesis potential.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       {ECO:0000256|ARBA:ARBA00005658}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EST31232.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AWQV01000695; EST31232.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6KGP0; -.
DR   PATRIC; fig|1380770.3.peg.3596; -.
DR   HOGENOM; CLU_010118_5_0_11; -.
DR   Proteomes; UP000017915; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071705; P:nitrogen compound transport; IEA:InterPro.
DR   InterPro; IPR018093; BCCT_CS.
DR   InterPro; IPR000060; BCCT_transptr.
DR   NCBIfam; TIGR00842; bcct; 1.
DR   PANTHER; PTHR30047:SF7; HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN; 1.
DR   PANTHER; PTHR30047; HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN-RELATED; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   PROSITE; PS01303; BCCT; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017915};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        33..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        71..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        121..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        171..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        461..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   534 AA;  57164 MW;  D11E99ABF879F4BB CRC64;
     MILGFVLFAV IGQKTAADAV ATVQSEVIGG LSWFYMALVS LFVIFCLWVG IGRYGDIKLG
     KDGERPEFSL VSWLAMLFAA GMGIGLVFWG VAEPLNFFDA PRPGTGSSDA AKSEFAMVQT
     FLHWGIHPWA IYVVVGLAVA YSVHRKGRPV SIRWALEPVF GDRIKGAWGD VIDSVAVIGT
     LFGVATSLGF GVMQVASGMD FLGWVDDGSS KGLLVVLIVC ITGIATLSVV TGIGKGIKWL
     SNANMGLAAL IMLFVLIAGP TLYLANSLVQ DTGGYLQNVL SLSFDTGASY GEEGTSWVNA
     WTVFYWGWWI SWAPFVGIFI ARISRGRTVR EFVCGVLLVP TLLTFVWFSI FGGTAVFQQA
     NGKHDYIGEA GVSTNNALFE MLDTLPGGTF VAGVAILLIV LFFVTSSDSG SYVVDMLASG
     GDPNPPVWSR VFWALTEGAV AIALLLASGS GGTASLDTLK TVAILVALPF SFVMIGMCWA
     TLRSFRQERE AYLAAKLQRQ QDRMVDEAVA ALEESLENGT LNSDGTTNVS TTKR
//