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Database: UniProt
Entry: V6KZ94_9ACTN
LinkDB: V6KZ94_9ACTN
Original site: V6KZ94_9ACTN 
ID   V6KZ94_9ACTN            Unreviewed;       373 AA.
AC   V6KZ94;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   05-JUL-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
DE   Flags: Fragment;
GN   ORFNames=N566_12975 {ECO:0000313|EMBL:EST37452.1};
OS   Streptomycetaceae bacterium MP113-05.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae.
OX   NCBI_TaxID=1380770 {ECO:0000313|EMBL:EST37452.1, ECO:0000313|Proteomes:UP000017915};
RN   [1] {ECO:0000313|EMBL:EST37452.1, ECO:0000313|Proteomes:UP000017915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP113-05 {ECO:0000313|EMBL:EST37452.1,
RC   ECO:0000313|Proteomes:UP000017915};
RA   Valde M., Degnes K.F., Sletta H., Ruckert C., Kalinowski J.,
RA   Zotchev S.B.;
RT   "Streptomyces bacterium from a marine sponge: physiological
RT   characterization and genome-based analysis of secondary metabolite
RT   biosynthesis potential.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00731929}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EST37452.1}.
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DR   EMBL; AWQV01000425; EST37452.1; -; Genomic_DNA.
DR   EnsemblBacteria; EST37452; EST37452; N566_12975.
DR   PATRIC; fig|1380770.3.peg.2249; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000017915; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017915};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00731880};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731910};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017915}.
FT   DOMAIN       66    194       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      280    349       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EST37452.1}.
SQ   SEQUENCE   373 AA;  41226 MW;  01AB3705EC2ED925 CRC64;
     YDGPSQLPAP SGAPGPLAAQ PAPATGPGEP TARLNPKYLF DTFVIGASNR FAHAAAVAVA
     EAPAKAYNPL FIYGESGLGK THLLHAIGHY ARSLYPGTRV RYVSSEEFTN EFINSIRDGK
     ADAFRKRYRD MDILLVDDVQ FLADKESTQE EFFHTFNTLH NANKQIVLSS DRPPKALVTL
     EDRLRNRFEW GLITDVQPPE LETRIAILRK KAVQERLNAP PEVLEFIASR ISRNIRELEG
     ALIRVTAFAS LNRQPVDLGL AEIVLKDLIP GGEDAAPEIT ATDIMAATAD YFGLSVDDLC
     GSSRSRVLVT ARQIAMYLCR ELTDLSLPKI GAQFGGRDHT TVMHADRKIR ALMAERRSIY
     NQVTELTNRI KNG
//
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